ATE428801T1 - Überwachung der hybridisierung während pcr - Google Patents

Überwachung der hybridisierung während pcr

Info

Publication number: ATE428801T1
Authority: AT; Austria
Prior art keywords: nucleic acid; target nucleic; acid sequence; biological sample; dye
Prior art date: 1996-06-04

Application number

AT97931089T

Other languages

English (en)

Inventor

Carl Wittwer

Kirk Ririe

Randy Rasmussen

Original Assignee

Univ Utah Res Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-04

Filing date

1997-06-04

Publication date

2009-05-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27097737&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE428801(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-06-04 Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found

2009-05-15 Application granted granted Critical

2009-05-15 Publication of ATE428801T1 publication Critical patent/ATE428801T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6823—Release of bound markers
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/251—Colorimeters; Construction thereof
- G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
- B01L2300/0838—Capillaries
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/18—Means for temperature control
- B01L2300/1838—Means for temperature control using fluid heat transfer medium
- B01L2300/1844—Means for temperature control using fluid heat transfer medium using fans
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N2021/6417—Spectrofluorimetric devices
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6482—Sample cells, cuvettes
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/0303—Optical path conditioning in cuvettes, e.g. windows; adapted optical elements or systems; path modifying or adjustment
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/07—Centrifugal type cuvettes
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Analytical Chemistry (AREA)
Immunology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biophysics (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Clinical Laboratory Science (AREA)
Spectroscopy & Molecular Physics (AREA)
Optics & Photonics (AREA)
Hematology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Fats And Perfumes (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)

AT97931089T 1996-06-04 1997-06-04 Überwachung der hybridisierung während pcr ATE428801T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US65899396A	1996-06-04	1996-06-04
US81826797A	1997-03-17	1997-03-17
PCT/US1997/010008 WO1997046714A1 (en)	1996-06-04	1997-06-04	Monitoring hybridization during pcr

Publications (1)

Publication Number	Publication Date
ATE428801T1 true ATE428801T1 (de)	2009-05-15

Family

ID=27097737

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT97931089T ATE428801T1 (de)	1996-06-04	1997-06-04	Überwachung der hybridisierung während pcr
AT99203548T ATE318327T1 (de)	1996-06-04	1997-06-04	Fluoreszenz-donor-akzeptor paar
AT01203467T ATE295427T1 (de)	1996-06-04	1997-06-04	Überwachung der hybridisierung während pcr

Family Applications After (2)

Application Number	Title	Priority Date	Filing Date
AT99203548T ATE318327T1 (de)	1996-06-04	1997-06-04	Fluoreszenz-donor-akzeptor paar
AT01203467T ATE295427T1 (de)	1996-06-04	1997-06-04	Überwachung der hybridisierung während pcr

Country Status (12)

Country	Link
US (9)	US6174670B1 (de)
EP (3)	EP0912766B2 (de)
JP (4)	JP4540754B2 (de)
AT (3)	ATE428801T1 (de)
AU (1)	AU726501B2 (de)
CA (3)	CA2658290C (de)
DE (3)	DE69733282T2 (de)
DK (2)	DK1179600T3 (de)
ES (2)	ES2326050T5 (de)
NZ (2)	NZ333136A (de)
PT (2)	PT912766E (de)
WO (1)	WO1997046714A1 (de)

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1997
- 1997-06-04 AT AT97931089T patent/ATE428801T1/de active
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Also Published As

Publication number	Publication date
CA2257109C (en)	2009-10-06
CA2658290A1 (en)	1997-12-11
EP0912766A1 (de)	1999-05-06
ATE318327T1 (de)	2006-03-15
ES2243393T3 (es)	2005-12-01
US7160998B2 (en)	2007-01-09
AU3481297A (en)	1998-01-05
DE69735313D1 (de)	2006-04-27
US20040002098A1 (en)	2004-01-01
EP0912766B1 (de)	2009-04-15
JP2008173127A (ja)	2008-07-31
JP2000509608A (ja)	2000-08-02
AU726501B2 (en)	2000-11-09
US20120258524A1 (en)	2012-10-11
US20020058258A1 (en)	2002-05-16
DE69739357D1 (de)	2009-05-28
US20090258414A1 (en)	2009-10-15
DK0912766T4 (da)	2012-04-02
JP2007185188A (ja)	2007-07-26
PT912766E (pt)	2009-07-16
CA2591550A1 (en)	1997-12-11
US6569627B2 (en)	2003-05-27
US20090311673A1 (en)	2009-12-17
CA2591550C (en)	2009-04-28
EP1179600B1 (de)	2005-05-11
NZ502323A (en)	2001-09-28
JP4540754B2 (ja)	2010-09-08
DE69733282D1 (de)	2005-06-16
EP0912766B2 (de)	2011-12-14
JP4118932B2 (ja)	2008-07-16
EP1179600A1 (de)	2002-02-13
JP4401416B2 (ja)	2010-01-20
CA2257109A1 (en)	1997-12-11
EP1033411A2 (de)	2000-09-06
US6245514B1 (en)	2001-06-12
EP1033411A3 (de)	2000-10-11
ATE295427T1 (de)	2005-05-15
DK1179600T3 (da)	2005-09-05
US20060029965A1 (en)	2006-02-09
NZ333136A (en)	2000-03-27
EP1033411B1 (de)	2006-02-22
US7670832B2 (en)	2010-03-02
CA2658290C (en)	2012-04-10
US6232079B1 (en)	2001-05-15
DE69733282T2 (de)	2006-01-19
DE69735313T2 (de)	2006-11-02
ES2326050T3 (es)	2009-09-29
DK0912766T3 (da)	2009-08-10
WO1997046714A1 (en)	1997-12-11
US6174670B1 (en)	2001-01-16
US8343754B2 (en)	2013-01-01
ES2326050T5 (es)	2012-04-26
PT1179600E (pt)	2005-08-31
JP2010046063A (ja)	2010-03-04

Publication	Publication Date	Title
ATE428801T1 (de)	2009-05-15	Überwachung der hybridisierung während pcr
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JP2004506431A5 (de)	2008-10-09
EA200300284A1 (ru)	2003-08-28	Способ амплификации нуклеиновых кислот
ES2179909T3 (es)	2003-02-01	Cebadores de oligonucleotidos para la amplificacion del acido nucleico del vhc.
DK0713921T3 (da)	2001-11-12	Fremgangsmåde til dæmpning af fluorescensen i opløsning af fluorescensmærkede oligonukleotidprober
CN102071251B (zh)	2013-05-01	一种pcr检测核酸的方法
DE69838210D1 (de)	2007-09-20	Markierter Primer, geeignet für die Detektion von Nukleinsäuren
IS2699B (is)	2010-11-15	Ákvörðun á samræmi DNA margbreytni með því að nota flæðigreiningu
KR970028548A (ko)	1997-06-24	핵산의 형광 편광도 검출방법
DK1805199T3 (da)	2011-04-26	Fremgangsmåder til nucleinsyreamplifikation
ES2094178T3 (es)	1997-01-16	Secuencias nucleotidicas utiles como sondas especificas del tipo cebadores pct y sondas para la amplificacion y deteccion del virus del papiloma humano, y kits y procedimientos utilizados con este fin.
ATE203775T1 (de)	2001-08-15	Methode zur detektion einer gezielten nukleinsäure
DE602004028993D1 (de)	2010-10-21	Neues Format zur Detektion von Heissstart- und Echtzeit-Polymerasekettenreaktion
JP6961700B2 (ja)	2021-11-05	生体サンプル中の遺伝物質を検出する方法及びその実施のための装置
JP2003506068A5 (de)	2007-09-27
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CA2252013A1 (en)	1999-05-28	Procedure for the detection of high virus concentrations in blood plasma and/or blood serum by means of the polymerase chain reaction
ATE287969T1 (de)	2005-02-15	Amplifizierungsverfahen zum nachweis von zielnukleinsäuren unter verwendung von fluoreszenzenergieübertragung
US20230279479A1 (en)	2023-09-07	Methods and systems for analyzing nucleic acids using increased ifret with multiple acceptor fluorophores
JP2004321127A (ja)	2004-11-18	ターゲット核酸断片の検出方法
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KR970703430A (ko)	1997-07-03	표적 핵산의 검출방법

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