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ATE236177T1 - Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen - Google Patents

Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen

Info

Publication number
ATE236177T1
ATE236177T1 AT97904727T AT97904727T ATE236177T1 AT E236177 T1 ATE236177 T1 AT E236177T1 AT 97904727 T AT97904727 T AT 97904727T AT 97904727 T AT97904727 T AT 97904727T AT E236177 T1 ATE236177 T1 AT E236177T1
Authority
AT
Austria
Prior art keywords
compounds
compositions
novel
enzyme
carbon
Prior art date
Application number
AT97904727T
Other languages
English (en)
Inventor
Hashem Akhavan-Tafti
Zahra Arghavani
Renuka Desilva
Original Assignee
Lumigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc filed Critical Lumigen Inc
Application granted granted Critical
Publication of ATE236177T1 publication Critical patent/ATE236177T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings
    • C07F9/6541Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/5765Six-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/64Acridine or hydrogenated acridine ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/42Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/968High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Luminescent Compositions (AREA)
AT97904727T 1996-01-16 1997-01-15 Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen ATE236177T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58509096A 1996-01-16 1996-01-16
US68392796A 1996-07-19 1996-07-19
PCT/US1997/000015 WO1997026245A1 (en) 1996-01-16 1997-01-15 Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes

Publications (1)

Publication Number Publication Date
ATE236177T1 true ATE236177T1 (de) 2003-04-15

Family

ID=27079286

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97904727T ATE236177T1 (de) 1996-01-16 1997-01-15 Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen

Country Status (10)

Country Link
US (8) US6045727A (de)
EP (1) EP0819119B1 (de)
JP (2) JP3169383B2 (de)
KR (1) KR100259144B1 (de)
CN (1) CN1173954C (de)
AT (1) ATE236177T1 (de)
AU (1) AU716233B2 (de)
CA (1) CA2213317C (de)
DE (1) DE69720332T2 (de)
WO (1) WO1997026245A1 (de)

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DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
ATE236177T1 (de) * 1996-01-16 2003-04-15 Lumigen Inc Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen
US6410732B2 (en) * 1996-01-16 2002-06-25 Lumigen, Inc. Processing and synthetic intermediates for preparing N-arylacridancarboxylic acid derivatives
US5965736A (en) * 1996-01-16 1999-10-12 Lumigen, Inc. Compositions and methods for generating red chemiluminescence
US5840963A (en) * 1997-05-13 1998-11-24 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
US5772926A (en) * 1997-05-13 1998-06-30 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
US5922558A (en) * 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase
US6126870A (en) * 1997-09-12 2000-10-03 Lumigen, Inc. Chemiluminescent labeling compounds
ATE266667T1 (de) * 1997-09-12 2004-05-15 Lumigen Inc Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase
AU2004200649B2 (en) * 1997-09-12 2007-01-18 Lumigen, Inc. Novel compounds for generating chemiluminescence with a peroxidase
FR2772129B1 (fr) * 1997-12-04 2000-02-25 Didier Roux Appareil et procedes de mesure sur un fluide en ecoulement avec cisaillement
US6017769A (en) * 1998-06-17 2000-01-25 Lumigen, Inc. Non-enzymatic methods of generating chemiluminescence from acridan alkenes
US6162610A (en) * 1998-09-11 2000-12-19 Tropix, Inc. Xanthan-ester and acridan substrates for horseradish peroxidase
ATE415409T1 (de) * 1999-05-24 2008-12-15 Invitrogen Corp Ein verfahren zum entschützen markierter oligonukleotide
US6783948B1 (en) 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
EP1322670B1 (de) * 2000-06-26 2005-12-21 Lumigen, Inc. Elektrochemilumineszenz von acridanzusammensetzungen
US7186568B1 (en) 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
US6617136B2 (en) 2001-04-24 2003-09-09 3M Innovative Properties Company Biological sample processing methods and compositions that include surfactants
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
US6867005B2 (en) 2001-10-24 2005-03-15 Beckman Coulter, Inc. Method and apparatus for increasing the dynamic range and accuracy of binding assays
US7560556B2 (en) * 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
US6608212B1 (en) * 2002-06-04 2003-08-19 Pfizer, Inc. Process for preparing vinylaromatic compounds
US6897036B2 (en) * 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
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US20040259182A1 (en) * 2003-06-17 2004-12-23 Brooks Edwards Arrays for chemiluminescent assays, methods of making the arrays and methods of detecting chemiluminescent emissions on solid supports
US20050019778A1 (en) * 2003-07-17 2005-01-27 Voyta John C. Sequential generation of multiple chemiluminescent signals on solid supports
US20050026151A1 (en) * 2003-07-17 2005-02-03 Voyta John C. Simultaneous generation of multiple chemiluminescent signals on solid supports
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AR052321A1 (es) * 2004-10-29 2007-03-14 Sandoz Ag Procesos para la preparacion de un polipeptido
US20090246888A1 (en) * 2005-04-27 2009-10-01 The Trustees Of The University Of Pennsylvania Nanoassays
US7919019B2 (en) * 2005-04-27 2011-04-05 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescent devices
WO2006116683A1 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescence
US20070037174A1 (en) * 2005-08-12 2007-02-15 Rampal Jang B Chemiluminescent generated fluorescent labeling
KR101243918B1 (ko) * 2006-01-03 2013-03-14 삼성디스플레이 주식회사 청색 발광 고분자, 그 제조방법 및 이를 채용한 유기 전계발광 소자
WO2007107810A1 (en) * 2006-03-20 2007-09-27 Council Of Scientific And Industrial Research A method for detecting the presence of water born pathogens and indicator microorganism
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CN101462316A (zh) * 2007-12-19 2009-06-24 维斯塔斯风力系统有限公司 预成型件的制备方法
WO2009137666A2 (en) * 2008-05-08 2009-11-12 The Trustees Of The University Of Pennsylvania Chemiluminescence enhanced detection
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CN102706869B (zh) * 2012-06-05 2014-09-17 宁波美康生物科技股份有限公司 碱性磷酸酶标记信号放大系统
CN103808712B (zh) * 2012-11-05 2017-12-19 深圳迈瑞生物医疗电子股份有限公司 一种用于酸性磷酸酶检测的液体试剂盒和检测方法
EP2799866A1 (de) * 2013-05-02 2014-11-05 Université Paris-Est Marne-la-Vallée Verfahren zur Bestimmung der Konzentration von nichtionischen Tensiden in einer wässrigen Lösung mittels Anregungs-Emissions-Fluoreszenzspektroskopie auf Basis der Verbesserung der Fluoreszenz von 6-p-toluidino-2-naphthalinsulfonsäure
CN104418887A (zh) * 2013-09-06 2015-03-18 江苏泽成生物技术有限公司 一种与磷酸酶反应产生化学发光的化合物、组合物和新型制备方法
CN103868913B (zh) * 2014-02-11 2017-07-14 中生北控生物科技股份有限公司 碱性磷酸酶的酶促化学发光底物液
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CN104230804B (zh) * 2014-08-30 2016-05-25 云南民族大学 化学发光物aps-5关键中间体的制备方法
CN105524608B (zh) * 2014-09-29 2017-09-22 中国科学院大连化学物理研究所 一种荧光探针ah及其制备和应用
CN105524609B (zh) * 2014-09-29 2017-09-22 中国科学院大连化学物理研究所 一种荧光探针gh及其制备和应用
CN104761584A (zh) * 2015-02-27 2015-07-08 北京利德曼生化股份有限公司 吖啶酯衍生物及其合成方法和应用
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CN106749404B (zh) * 2016-12-07 2019-01-04 湖南远璟生物技术有限公司 一种与碱性磷酸酶反应产生化学发光的化合物的制备方法
CN109187514B (zh) * 2018-11-28 2020-12-08 广西壮族自治区农业科学院农产品质量安全与检测技术研究所 一种基于纳米金表面的化学发光共振能量转移传感器快速检测百草枯的方法
CN110632290B (zh) * 2019-09-27 2022-04-12 昆山迪安医学检验实验室有限公司 一种抗双链dna抗体检测试剂
CN110734412B (zh) * 2019-11-08 2021-08-13 扬州工业职业技术学院 一种苯并噻唑衍生物及其合成方法与作为抗菌药物的应用
CN112342018B (zh) * 2020-10-27 2022-08-19 武汉生之源生物科技股份有限公司 一种化合物aps5-cqd及其制备方法、化学发光底物液
CN112710653B (zh) * 2020-12-10 2024-08-30 达州职业技术学院 一种快速检测潜在血渍的专用试剂及其制备方法
CN114609263B (zh) * 2021-11-30 2024-06-18 苏州正济药业有限公司 一种(r)-2,4-二碘-3-甲基-1-烯及其对映异构体的检测方法
CN114624205B (zh) * 2022-02-28 2024-07-23 海南绿峰资源开发有限公司 一种碱性磷酸酶的检测方法

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Also Published As

Publication number Publication date
DE69720332D1 (de) 2003-05-08
CN1173954C (zh) 2004-11-03
US6090571A (en) 2000-07-18
US6270695B1 (en) 2001-08-07
US6045991A (en) 2000-04-04
DE69720332T2 (de) 2003-12-04
JPH10510848A (ja) 1998-10-20
US20030023089A1 (en) 2003-01-30
KR100259144B1 (ko) 2000-07-01
EP0819119A4 (de) 1999-04-14
AU716233B2 (en) 2000-02-24
US6635437B2 (en) 2003-10-21
WO1997026245A1 (en) 1997-07-24
CN1180349A (zh) 1998-04-29
EP0819119B1 (de) 2003-04-02
JP3169383B2 (ja) 2001-05-21
CA2213317C (en) 2001-07-03
US6139782A (en) 2000-10-31
US6296787B1 (en) 2001-10-02
US6045727A (en) 2000-04-04
CA2213317A1 (en) 1997-07-24
JP2001158794A (ja) 2001-06-12
US6218137B1 (en) 2001-04-17
EP0819119A1 (de) 1998-01-21
AU1744697A (en) 1997-08-11
KR19980703068A (ko) 1998-09-05

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