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DE69823845D1 - Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase - Google Patents

Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase

Info

Publication number
DE69823845D1
DE69823845D1 DE69823845T DE69823845T DE69823845D1 DE 69823845 D1 DE69823845 D1 DE 69823845D1 DE 69823845 T DE69823845 T DE 69823845T DE 69823845 T DE69823845 T DE 69823845T DE 69823845 D1 DE69823845 D1 DE 69823845D1
Authority
DE
Germany
Prior art keywords
peroxidase
aid
chemiluminescence
new compounds
generating chemiluminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69823845T
Other languages
English (en)
Other versions
DE69823845T2 (de
Inventor
Hashem Akhavan-Tafti
Zahra Arghavani
Renuka Desilva
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lumigen Inc
Original Assignee
Lumigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc filed Critical Lumigen Inc
Application granted granted Critical
Publication of DE69823845D1 publication Critical patent/DE69823845D1/de
Publication of DE69823845T2 publication Critical patent/DE69823845T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/06Phosphorus compounds without P—C bonds
    • C07F9/08Esters of oxyacids of phosphorus
    • C07F9/09Esters of phosphoric acids
    • C07F9/113Esters of phosphoric acids with unsaturated acyclic alcohols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D219/00Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/08Aza-anthracenes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/64Acridine or hydrogenated acridine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655363Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
    • C07F9/655372Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69823845T 1997-09-12 1998-08-12 Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase Expired - Lifetime DE69823845T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92738197A 1997-09-12 1997-09-12
US927381 1997-09-12
PCT/US1998/015734 WO1999014220A1 (en) 1997-09-12 1998-08-12 Novel compounds for generating chemiluminescence with a peroxidase

Publications (2)

Publication Number Publication Date
DE69823845D1 true DE69823845D1 (de) 2004-06-17
DE69823845T2 DE69823845T2 (de) 2005-04-28

Family

ID=25454661

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69823845T Expired - Lifetime DE69823845T2 (de) 1997-09-12 1998-08-12 Neue verbindungen zur erzeugung von chemilumineszenz mit hilfe einer peroxidase

Country Status (8)

Country Link
US (2) US6696569B2 (de)
EP (1) EP1015461B1 (de)
JP (1) JP4431272B2 (de)
AT (1) ATE266667T1 (de)
AU (1) AU9102398A (de)
CA (1) CA2300071C (de)
DE (1) DE69823845T2 (de)
WO (1) WO1999014220A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017769A (en) * 1998-06-17 2000-01-25 Lumigen, Inc. Non-enzymatic methods of generating chemiluminescence from acridan alkenes
EP1322670B1 (de) * 2000-06-26 2005-12-21 Lumigen, Inc. Elektrochemilumineszenz von acridanzusammensetzungen
US6872828B2 (en) 2001-12-20 2005-03-29 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
US7589180B2 (en) 2001-05-11 2009-09-15 Abbott Laboratories Inc. Specific binding proteins and uses thereof
US20100056762A1 (en) 2001-05-11 2010-03-04 Old Lloyd J Specific binding proteins and uses thereof
US7560556B2 (en) * 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
CN1332950C (zh) 2001-12-20 2007-08-22 鲁米根公司 与过氧化物酶产生化学发光的改进化合物
US6897036B2 (en) 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
ATE429507T1 (de) * 2004-07-02 2009-05-15 Promega Corp Zusammensetzungen und verfahren zur extraktion und detektion von mikrobiellem atp
US20090246888A1 (en) * 2005-04-27 2009-10-01 The Trustees Of The University Of Pennsylvania Nanoassays
US7919019B2 (en) * 2005-04-27 2011-04-05 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescent devices
WO2006116683A1 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescence
WO2007082899A1 (en) 2006-01-17 2007-07-26 Vib Vzw Inhibitors of prolyl-hydroxylase 1 for the treatment of skeletal muscle degeneration
US7799534B2 (en) * 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
WO2008033495A2 (en) * 2006-09-15 2008-03-20 Life Science Pharmaceuticals Method for detecting and treating skin disorders
US8173423B2 (en) 2006-11-07 2012-05-08 Vib Vzw Diagnosis and treatment of T-cell acute lymphoblastic leukemia
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
CN102333885A (zh) * 2009-02-27 2012-01-25 贝克曼考尔特公司 使用选择性信号抑制剂的非分离式测定
ES2622977T3 (es) 2009-02-27 2017-07-10 Beckman Coulter, Inc. Ensayos homogéneos con fase de disolución
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
EP2535027B1 (de) 2011-06-17 2022-08-17 The Procter & Gamble Company Absorbierender Artikel mit verbesserten Absorptionseigenschaften
CN107080619A (zh) 2011-11-21 2017-08-22 宝洁公司 具有改善的吸收性能的吸收制品
CN104761584A (zh) * 2015-02-27 2015-07-08 北京利德曼生化股份有限公司 吖啶酯衍生物及其合成方法和应用
EP3821029A1 (de) 2018-07-13 2021-05-19 3M Innovative Properties Company Test
JP7055975B2 (ja) 2018-07-13 2022-04-19 スリーエム イノベイティブ プロパティズ カンパニー 特異的結合化学発光アッセイ

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE62237B1 (en) * 1988-01-14 1995-01-11 Nihon Nohyaku Co Ltd Ketenedithioacetal derivatives and processes for producing the same as well as a composition containing the same
EP0361470B1 (de) * 1988-09-30 1993-12-22 Fujirebio Inc. Verfahren zur Bestimmung von Peroxidase-Aktivität unter Verwendung von Chemilumineszenz
EP0422252B1 (de) * 1989-04-28 1995-07-26 Toray Industries, Inc. Verfahren zur Bestimmung einer Substanz durch Verwendung von chemilumineszenz
US5324835A (en) * 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
US5648484A (en) * 1995-03-07 1997-07-15 Schering Corporation Catalytic enantioselective synthesis of a spriofused azetidinone
ATE236177T1 (de) * 1996-01-16 2003-04-15 Lumigen Inc Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen
US6126870A (en) * 1997-09-12 2000-10-03 Lumigen, Inc. Chemiluminescent labeling compounds

Also Published As

Publication number Publication date
EP1015461B1 (de) 2004-05-12
US20010039345A1 (en) 2001-11-08
JP4431272B2 (ja) 2010-03-10
DE69823845T2 (de) 2005-04-28
ATE266667T1 (de) 2004-05-15
EP1015461A1 (de) 2000-07-05
CA2300071C (en) 2009-04-07
US6696569B2 (en) 2004-02-24
CA2300071A1 (en) 1999-03-25
AU9102398A (en) 1999-04-05
US20040144948A1 (en) 2004-07-29
EP1015461A4 (de) 2001-07-11
WO1999014220A1 (en) 1999-03-25
JP2001516760A (ja) 2001-10-02
US6891057B2 (en) 2005-05-10

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