ATE115587T1 - 11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase. - Google Patents

11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase.

Info

Publication number: ATE115587T1
Authority: AT; Austria
Prior art keywords: alpha; keto; steroids; steroid; hydroxy
Prior art date: 1989-11-01

Application number

AT90311807T

Other languages

English (en)

Inventor

Dennis Alan Holt

Brian Walter Metcalf

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-01

Filing date

1990-10-29

Publication date

1994-12-15

1990-10-29 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1994-12-15 Application granted granted Critical

1994-12-15 Publication of ATE115587T1 publication Critical patent/ATE115587T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT90311807T 1989-11-01 1990-10-29 11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase. ATE115587T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/430,152 US5041433A (en)	1987-04-29	1989-11-01	11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase

Publications (1)

Publication Number	Publication Date
ATE115587T1 true ATE115587T1 (de)	1994-12-15

Family

ID=23706275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90311807T ATE115587T1 (de)	1989-11-01	1990-10-29	11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase.

Country Status (15)

Country	Link
US (1)	US5041433A (de)
EP (1)	EP0427434B1 (de)
JP (1)	JPH03169890A (de)
KR (1)	KR100187945B1 (de)
AT (1)	ATE115587T1 (de)
AU (1)	AU641701B2 (de)
CA (1)	CA2028622A1 (de)
DE (1)	DE69015129T2 (de)
DK (1)	DK0427434T3 (de)
ES (1)	ES2064661T3 (de)
GR (1)	GR3015372T3 (de)
IE (1)	IE65562B1 (de)
NZ (1)	NZ235871A (de)
PT (1)	PT95750A (de)
ZA (1)	ZA908730B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5516768A (en) *	1990-03-16	1996-05-14	Smithkline Beecham Corporation	Uncompetitive inhibition of steroid and 5α-reductose
US5300294A (en) *	1990-06-27	1994-04-05	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
IT1259419B (it) *	1991-05-24	1996-03-18	Erba Carlo Spa	Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
NZ245504A (en) *	1991-12-20	1995-08-28	Hoechst Ag	Bile acid derivatives containing an ethylenically unsaturated grouping
US5215894A (en) *	1992-02-25	1993-06-01	Merck & Co., Inc.	Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
EP0641211A1 (de) *	1992-05-21	1995-03-08	Endorecherche Inc.	Testosteron-5-alpha-reduktase-inhibitonen
US5641765A (en) *	1992-11-18	1997-06-24	Smithkline Beecham Corporation	17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
AP9300589A0 (en) *	1992-11-18	1994-01-31	Smithkline Beecham Corp	Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase.
US5683995A (en) *	1992-11-18	1997-11-04	Smithkline Beecham Corporation	17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5637310A (en) *	1993-12-20	1997-06-10	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
WO1995028413A1 (en) *	1994-04-15	1995-10-26	Smithkline Beecham Corporation	17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
WO1999061055A1 (en)	1998-05-22	1999-12-02	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US20060148725A1 (en) *	2001-12-21	2006-07-06	The Miriam Hospital	Selective 11beta HSD inhibitors and methods of use thereof
EP1587574A4 (de) *	2001-12-21	2009-03-18	Rhode Island Hospital	SELEKTIVE 11b-HSD-HEMMER UND ANWENDUNGSVERFAHREN DAFÜR
US20050020550A1 (en) *	2003-04-29	2005-01-27	Morris David J.	Selective testicular 11beta-HSD inhibitors and methods of use thereof
WO2006116718A2 (en)	2005-04-28	2006-11-02	Proteus Biomedical, Inc.	Pharma-informatics system
WO2007035716A2 (en)	2005-09-16	2007-03-29	Raptor Pharmaceutical Inc.	Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
CN104208718B (zh)	2009-02-20	2017-12-29	2-Bbb医疗股份有限公司	基于谷胱甘肽的药物递送系统
MY163048A (en)	2009-05-06	2017-08-15	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4191759A (en) *	1978-04-13	1980-03-04	Merck & Co., Inc.	N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4317817A (en) *	1979-08-27	1982-03-02	Richardson-Merrell Inc.	Novel steroid 5α-reductase inhibitors
DK465481A (da) *	1980-11-21	1982-05-22	Hoffmann La Roche	Fremgangsmaade til fremstilling af d-homostemoider
US4814324A (en) *	1987-03-06	1989-03-21	Merck & Co., Inc.	Sterol inhibitors of testosterone 5α-reductase
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1989
- 1989-11-01 US US07/430,152 patent/US5041433A/en not_active Expired - Lifetime
1990
- 1990-10-26 CA CA002028622A patent/CA2028622A1/en not_active Abandoned
- 1990-10-26 AU AU65511/90A patent/AU641701B2/en not_active Ceased
- 1990-10-29 ES ES90311807T patent/ES2064661T3/es not_active Expired - Lifetime
- 1990-10-29 EP EP90311807A patent/EP0427434B1/de not_active Expired - Lifetime
- 1990-10-29 DK DK90311807.3T patent/DK0427434T3/da active
- 1990-10-29 NZ NZ235871A patent/NZ235871A/en unknown
- 1990-10-29 AT AT90311807T patent/ATE115587T1/de not_active IP Right Cessation
- 1990-10-29 DE DE69015129T patent/DE69015129T2/de not_active Expired - Fee Related
- 1990-10-31 IE IE392090A patent/IE65562B1/en unknown
- 1990-10-31 ZA ZA908730A patent/ZA908730B/xx unknown
- 1990-10-31 JP JP2297020A patent/JPH03169890A/ja active Pending
- 1990-10-31 PT PT95750A patent/PT95750A/pt not_active Application Discontinuation
- 1990-11-01 KR KR1019900017704A patent/KR100187945B1/ko not_active IP Right Cessation
1995
- 1995-03-13 GR GR940403878T patent/GR3015372T3/el unknown

Also Published As

Publication number	Publication date
AU641701B2 (en)	1993-09-30
ES2064661T3 (es)	1995-02-01
IE65562B1 (en)	1995-11-01
CA2028622A1 (en)	1991-05-02
EP0427434A2 (de)	1991-05-15
AU6551190A (en)	1991-07-18
US5041433A (en)	1991-08-20
EP0427434A3 (en)	1992-03-04
IE903920A1 (en)	1991-05-08
NZ235871A (en)	1991-12-23
PT95750A (pt)	1991-09-13
DE69015129D1 (de)	1995-01-26
JPH03169890A (ja)	1991-07-23
EP0427434B1 (de)	1994-12-14
ZA908730B (en)	1991-11-27
DE69015129T2 (de)	1995-05-04
GR3015372T3 (en)	1995-06-30
KR910009725A (ko)	1991-06-28
KR100187945B1 (ko)	1999-06-01
DK0427434T3 (da)	1995-05-08

Publication	Publication Date	Title
ATE115587T1 (de)	1994-12-15	11-keto- oder hydroxy-3,5-diensteroiden als inhibitoren der steroid-5-alpha-reduktase.
DK0414529T3 (da)	1995-05-22	Substituerede steroidderivater
DE3871965D1 (de)	1992-07-23	Steroid-5-alpha-reduktase-inhibitoren.
PT80157B (en)	1987-03-20	Methods of treating viral diseases with pyridazinamines anti-virally active pyridazinamines
DE68917884D1 (de)	1994-10-06	Phosphinsäure-Derivate von Steroiden als 5-alpha-Reduktase-Inhibitoren.
EP0613883A4 (de)	1994-12-07	Hydroxamsäure derivate.
IE881269L (en)	1988-10-29	Steroids
EP0151824A3 (en)	1985-10-09	N-(4-piperidinyl) bicyclic condesed 2-imidazolamine derivatives
DK0564350T3 (da)	1997-12-15	3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning
ES8604189A1 (es)	1986-01-16	Un procedimiento para la preparacion de nuevos derivados delcromano
NZ230973A (en)	1993-03-26	Process for the preparation of 7-substituted, hept-6-enoic and heptanoic acids and selected derivatives and optical isomers
KR960014782B1 (en)	1996-10-19	Benzisothiazolinone 1-dioxide derivatives and elastase inhibitors composition comprising them
ES2156120T3 (es)	2001-06-16	Derivados arilamidicos.
NO923265D0 (no)	1992-08-20	Benzol(f)quinolinoner
PT100583A (pt)	1993-09-30	Metodo de tratamento e/ou profilaxia utilizando,por exemplo, derivados de benzopirano, composicoes que os contem, compostos utilizados e processos para a sua preparacao
FI935777A0 (fi)	1993-12-21	Inhibitorer foer HIV-proteas anvaendbara vid behandling av AIDS
FI102964B (fi)	1999-03-31	Menetelmä terapeuttisesti käyttökelpoisen 4-substituoitu-1-(9,10-dihyd ro-9,10-metanoantrasen-9-yylimetyyli)piperidin-4-olijohdannaisen tuott amiseksi sekä menetelmän välituotteet
ATE92960T1 (de)	1993-08-15	Alpha-1-antitrypsin-varianten, besonders verwendbar als kallikrein-inhibitoren.
ATE242765T1 (de)	2003-06-15	S-2'-(2-(1-methyl-2-piperidyl) ethyl) cinnamanilide als 5-ht2 rezeptor antagonist
ATE182890T1 (de)	1999-08-15	3-alkyloxy-, aryloxy-, oder arylalkyloxy- benzo(b>thiophen- 2-carboxamide als inhibitoren von zelladhäsion
ZA907736B (en)	1991-11-27	Derivatives of pyridone,process and intermediates of preparation,their application as medicaments and compositions containing them
BG96487A (bg)	1993-12-24	Р-заместени производни на 4-оксибутанамина,методи за получаването им и тяхното приложение
AU640161B2 (en)	1993-08-19	3-substituted nitro-steroid derivatives as 5-alpha-reductase inhibitors
JPS5692260A (en)	1981-07-25	Cyclohexanecarboxylic ester and its preparation
AR241434A1 (es)	1992-07-31	Procedimiento para la preparacion de 3-(piperidinil)-1h-indazoles.

Legal Events

Date	Code	Title	Description
1995-05-15	UEP	Publication of translation of european patent specification
2008-07-15	REN	Ceased due to non-payment of the annual fee