GR3015372T3 - 11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase. - Google Patents

11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase.

Info

Publication number: GR3015372T3
Authority: GR; Greece
Prior art keywords: alpha; keto; reductase; inhibitors; steroid
Prior art date: 1989-11-01

Application number

GR940403878T

Other languages

English (en)

Inventor

Dennis Alan Holt

Brian Walter Metcalf

Mark Alan Levy

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-01

Filing date

1995-03-13

Publication date

1995-06-30

1995-03-13 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1995-06-30 Publication of GR3015372T3 publication Critical patent/GR3015372T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J61/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/002—Expansion of ring A by one atom, e.g. A homo steroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
- C07J7/0095—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 carbon in position 21 is part of carboxylic group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Toxicology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GR940403878T 1989-11-01 1995-03-13 11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase. GR3015372T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/430,152 US5041433A (en)	1987-04-29	1989-11-01	11-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-α-reductase

Publications (1)

Publication Number	Publication Date
GR3015372T3 true GR3015372T3 (en)	1995-06-30

Family

ID=23706275

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR940403878T GR3015372T3 (en)	1989-11-01	1995-03-13	11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase.

Country Status (15)

Country	Link
US (1)	US5041433A (el)
EP (1)	EP0427434B1 (el)
JP (1)	JPH03169890A (el)
KR (1)	KR100187945B1 (el)
AT (1)	ATE115587T1 (el)
AU (1)	AU641701B2 (el)
CA (1)	CA2028622A1 (el)
DE (1)	DE69015129T2 (el)
DK (1)	DK0427434T3 (el)
ES (1)	ES2064661T3 (el)
GR (1)	GR3015372T3 (el)
IE (1)	IE65562B1 (el)
NZ (1)	NZ235871A (el)
PT (1)	PT95750A (el)
ZA (1)	ZA908730B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5516768A (en) *	1990-03-16	1996-05-14	Smithkline Beecham Corporation	Uncompetitive inhibition of steroid and 5α-reductose
US5300294A (en) *	1990-06-27	1994-04-05	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
IT1259419B (it) *	1991-05-24	1996-03-18	Erba Carlo Spa	Steroidi 3-carbossi 17b - sostituiti insaturi utili come inibitori della testosterone 5 a reduttasi
NZ245504A (en) *	1991-12-20	1995-08-28	Hoechst Ag	Bile acid derivatives containing an ethylenically unsaturated grouping
US5215894A (en) *	1992-02-25	1993-06-01	Merck & Co., Inc.	Biological process for producing 17β-N-monosubstituted carbamoyl-11-oxo-4-aza-5-α-androst-3-one testosterone-5-α reductase inhibitors
EP0641211A1 (en) *	1992-05-21	1995-03-08	Endorecherche Inc.	INHIBITORS OF TESTOSTERONE 5$g(a)-REDUCTASE ACTIVITY
US5641765A (en) *	1992-11-18	1997-06-24	Smithkline Beecham Corporation	17-αand 17-βsubstituted acyl-3-carboxy-3,5-dienes and use in inhibiting 5-α-reductase
AP9300589A0 (en) *	1992-11-18	1994-01-31	Smithkline Beecham Corp	Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase.
US5683995A (en) *	1992-11-18	1997-11-04	Smithkline Beecham Corporation	17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
TW369521B (en) *	1993-09-17	1999-09-11	Smithkline Beecham Corp	Androstenone derivative
US5637310A (en) *	1993-12-20	1997-06-10	Smithkline Beecham Corporation	Method of treating prostatic adenocarcinoma
WO1995028413A1 (en) *	1994-04-15	1995-10-26	Smithkline Beecham Corporation	17β-SUBSTITUTED 3-CARBOXY STEROIDS THAT INHIBIT 5-α-REDUCTASE
US5541322A (en) *	1994-10-14	1996-07-30	Glaxo Wellcome Inc.	Synthesis of 6-azaandrostenones
WO1999061055A1 (en)	1998-05-22	1999-12-02	The Board Of Trustees Of The Leland Stanford Junior University	Bifunctional molecules and therapies based thereon
US20060148725A1 (en) *	2001-12-21	2006-07-06	The Miriam Hospital	Selective 11beta HSD inhibitors and methods of use thereof
EP1587574A4 (en) *	2001-12-21	2009-03-18	Rhode Island Hospital	11b-HSD SELECTIVE INHIBITORS AND METHODS OF USE
US20050020550A1 (en) *	2003-04-29	2005-01-27	Morris David J.	Selective testicular 11beta-HSD inhibitors and methods of use thereof
WO2006116718A2 (en)	2005-04-28	2006-11-02	Proteus Biomedical, Inc.	Pharma-informatics system
WO2007035716A2 (en)	2005-09-16	2007-03-29	Raptor Pharmaceutical Inc.	Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
CN104208718B (zh)	2009-02-20	2017-12-29	2-Bbb医疗股份有限公司	基于谷胱甘肽的药物递送系统
MY163048A (en)	2009-05-06	2017-08-15	Laboratory Skin Care Inc	Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4191759A (en) *	1978-04-13	1980-03-04	Merck & Co., Inc.	N-substituted-17β-carbamoylandrost-4-en-3-one 5α reductase inhibitors
US4377584A (en) *	1978-04-13	1983-03-22	Merck & Co., Inc.	4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4317817A (en) *	1979-08-27	1982-03-02	Richardson-Merrell Inc.	Novel steroid 5α-reductase inhibitors
DK465481A (da) *	1980-11-21	1982-05-22	Hoffmann La Roche	Fremgangsmaade til fremstilling af d-homostemoider
US4814324A (en) *	1987-03-06	1989-03-21	Merck & Co., Inc.	Sterol inhibitors of testosterone 5α-reductase
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors

1989
- 1989-11-01 US US07/430,152 patent/US5041433A/en not_active Expired - Lifetime
1990
- 1990-10-26 CA CA002028622A patent/CA2028622A1/en not_active Abandoned
- 1990-10-26 AU AU65511/90A patent/AU641701B2/en not_active Ceased
- 1990-10-29 ES ES90311807T patent/ES2064661T3/es not_active Expired - Lifetime
- 1990-10-29 EP EP90311807A patent/EP0427434B1/en not_active Expired - Lifetime
- 1990-10-29 DK DK90311807.3T patent/DK0427434T3/da active
- 1990-10-29 NZ NZ235871A patent/NZ235871A/en unknown
- 1990-10-29 AT AT90311807T patent/ATE115587T1/de not_active IP Right Cessation
- 1990-10-29 DE DE69015129T patent/DE69015129T2/de not_active Expired - Fee Related
- 1990-10-31 IE IE392090A patent/IE65562B1/en unknown
- 1990-10-31 ZA ZA908730A patent/ZA908730B/xx unknown
- 1990-10-31 JP JP2297020A patent/JPH03169890A/ja active Pending
- 1990-10-31 PT PT95750A patent/PT95750A/pt not_active Application Discontinuation
- 1990-11-01 KR KR1019900017704A patent/KR100187945B1/ko not_active IP Right Cessation
1995
- 1995-03-13 GR GR940403878T patent/GR3015372T3/el unknown

Also Published As

Publication number	Publication date
AU641701B2 (en)	1993-09-30
ES2064661T3 (es)	1995-02-01
IE65562B1 (en)	1995-11-01
CA2028622A1 (en)	1991-05-02
EP0427434A2 (en)	1991-05-15
AU6551190A (en)	1991-07-18
US5041433A (en)	1991-08-20
EP0427434A3 (en)	1992-03-04
IE903920A1 (en)	1991-05-08
NZ235871A (en)	1991-12-23
PT95750A (pt)	1991-09-13
ATE115587T1 (de)	1994-12-15
DE69015129D1 (de)	1995-01-26
JPH03169890A (ja)	1991-07-23
EP0427434B1 (en)	1994-12-14
ZA908730B (en)	1991-11-27
DE69015129T2 (de)	1995-05-04
KR910009725A (ko)	1991-06-28
KR100187945B1 (ko)	1999-06-01
DK0427434T3 (da)	1995-05-08

Publication	Publication Date	Title
EP0427434A3 (en)	1992-03-04	11-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase
ZA906710B (en)	1991-09-25	7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha-reductase
ZA899671B (en)	1990-11-28	Phosphinic acid substituted steroids as inhibitors of steroid 5-alpha-reductase
IE881269L (en)	1988-10-29	Steroids
ZA88549B (en)	1988-07-27	Steroid 5-alpha-reductase inhibitors
ZA899670B (en)	1990-11-28	Phosphonic acid substituted steroids as steroid 5-alpha-reductase inhibitors
AP9300589A0 (en)	1994-01-31	Novel 17a and 17b substituted acyl-3-carboxy 3,5-diene steroidal compounds, pharmaceutical compositions containing these compounds, and methods for using these compounds to inhibit steroid 5-a-reductase.
AU640161B2 (en)	1993-08-19	3-substituted nitro-steroid derivatives as 5-alpha-reductase inhibitors
HU0000228D0 (en)	2000-03-28	2,2-dimethyl-3[1,3-dihalogene-2-oxo-propyl]-cyclopropanecarboxylate derivatives and process for producing thereof
AU7329687A (en)	1987-11-26	Steroids useful as anti-cancer and anti-obesity agents
NO945074L (no)	1995-02-16	17-Alkyleton-steroider anvendelige som 5- itorer