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ES8604189A1 - Un procedimiento para la preparacion de nuevos derivados delcromano - Google Patents

Un procedimiento para la preparacion de nuevos derivados delcromano

Info

Publication number
ES8604189A1
ES8604189A1 ES541229A ES541229A ES8604189A1 ES 8604189 A1 ES8604189 A1 ES 8604189A1 ES 541229 A ES541229 A ES 541229A ES 541229 A ES541229 A ES 541229A ES 8604189 A1 ES8604189 A1 ES 8604189A1
Authority
ES
Spain
Prior art keywords
alkyl
optionally substituted
alkoxy
hydrogen
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541229A
Other languages
English (en)
Other versions
ES541229A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838313688A external-priority patent/GB8313688D0/en
Priority claimed from GB838313683A external-priority patent/GB8313683D0/en
Priority claimed from GB838313681A external-priority patent/GB8313681D0/en
Priority claimed from GB838313676A external-priority patent/GB8313676D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES541229A0 publication Critical patent/ES541229A0/es
Publication of ES8604189A1 publication Critical patent/ES8604189A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DEL CROMANO. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN UN DISOLVENTE, COMO CLORURO DE METILENO, A UNA TEMPERATURA AMBIENTE BAJA, A MENOS DE 10JC, PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO: UNO DE R1 Y R2, H Y EL OTRO SE SELECCIONA ENTRE ALQUIL DE CL A 6 CARBONILO, ALCOXI DE C 1 A 6 CARBONILO U OTROS, O UNO DE R1 Y R2 ES NITRO, CIANO O ALQUIL DE C 1 A 3 CARBONILO Y EL OTRO ES METOXI O AMINO OPCIONALMENTE SUSTITUIDO; UNO DE R3 Y R4 ES H O ALQUILO DE C 1 A 4 Y EL OTRO ES ALQUILO C 1 A 4; R5, H, HIDROXI U OTROS; R6, H; R7, AMINO OPCIONALMENTE SUSTITUIDO; R8, H O ALQUILO DE C 1 A 6; X, O, O S; R1 Y R2 SON R1 Y R2 O UN GRUPO O ATOMO CONVERTIBLES EN ESTOS; R5, H, HIDROXI U OTROS; R6, H; Y R11, H, ALQUILO C 1 A 6, ALQUENILO DE C 1 A 6 U OTROS. SE UTILIZA EN EL TRATAMIENTO DE MAMIFEROS.
ES541229A 1983-05-18 1985-03-13 Un procedimiento para la preparacion de nuevos derivados delcromano Expired ES8604189A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB838313688A GB8313688D0 (en) 1983-05-18 1983-05-18 Active compounds
GB838313683A GB8313683D0 (en) 1983-05-18 1983-05-18 Active compounds
GB838313681A GB8313681D0 (en) 1983-05-18 1983-05-18 Active compounds
GB838313676A GB8313676D0 (en) 1983-05-18 1983-05-18 Active compounds

Publications (2)

Publication Number Publication Date
ES541229A0 ES541229A0 (es) 1986-01-16
ES8604189A1 true ES8604189A1 (es) 1986-01-16

Family

ID=27449480

Family Applications (2)

Application Number Title Priority Date Filing Date
ES532591A Expired ES8506300A1 (es) 1983-05-18 1984-05-17 Un procedimiento para la preparacion de nuevos derivados de cromano.
ES541229A Expired ES8604189A1 (es) 1983-05-18 1985-03-13 Un procedimiento para la preparacion de nuevos derivados delcromano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES532591A Expired ES8506300A1 (es) 1983-05-18 1984-05-17 Un procedimiento para la preparacion de nuevos derivados de cromano.

Country Status (9)

Country Link
US (1) US4575511A (es)
EP (1) EP0126367B1 (es)
JP (1) JPH0631210B2 (es)
AU (1) AU569587B2 (es)
CA (1) CA1236110A (es)
DE (1) DE3486354T2 (es)
ES (2) ES8506300A1 (es)
GR (1) GR81588B (es)
NZ (1) NZ208170A (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126311B1 (en) * 1983-05-18 1989-09-13 Beecham Group Plc Benzopyran derivatives.
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
EP0205292B1 (en) 1985-06-08 1991-11-06 Beecham Group Plc Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
EP0218373B1 (en) * 1985-09-11 1990-03-07 Beecham Group Plc Chroman derivatives and analogues having antihypertensive activity
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
NZ225813A (en) * 1987-09-02 1990-11-27 Mobil Oil Corp Zsm-5 in crystal form having specific dimensions, and preparation thereof
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
EP0359537B1 (en) * 1988-09-16 1996-06-26 Beecham Group Plc Benzopyran derivatives with antihypertensive activity
FR2661676A1 (fr) * 1990-05-02 1991-11-08 Lipha Derives d'amino benzocycloalcanes, procedes de preparation et medicaments les contenant.
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
AU651105B2 (en) * 1990-06-18 1994-07-14 E.R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
US5164509A (en) * 1990-11-26 1992-11-17 E. R. Squibb & Sons, Inc. Benzodiazolo analogs
US5401848A (en) * 1990-11-26 1995-03-28 E. R. Squibb & Sons, Inc. Indane and quinoline derivatives
FR2695387B1 (fr) * 1992-09-09 1994-10-21 Adir Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US5393771A (en) * 1993-05-12 1995-02-28 Brisol-Myers Squibb Company 4-substituted benzopyran and related compounds
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
GB9822024D0 (en) * 1998-10-09 1998-12-02 Novartis Ag Organic compounds
WO2009095726A1 (en) * 2008-01-29 2009-08-06 Glenmark Pharmaceuticals, S.A. Acrylamide derivatives as vanilloid receptor 1 modulators

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115407A (en) * 1977-07-01 1978-09-19 Morton-Norwich Products, Inc. N-Benzyl-4-chromanamines
DE3067552D1 (en) * 1979-09-15 1984-05-24 Yorkshire Imperial Plastics Apparatus for use in the manufacture of thermoplastics pipe by the radial expansion of a pipe blank within a circular cross-section mould
DE3064286D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064285D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0035868A1 (en) * 1980-03-07 1981-09-16 Takeda Chemical Industries, Ltd. Bicyclic compounds, their production and use
DE3170604D1 (en) * 1980-08-21 1985-06-27 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
ATE23718T1 (de) * 1981-09-25 1986-12-15 Beecham Group Plc Benzopyran-verbindungen mit pharmazeutischer wirkung.
EP0093535B1 (en) * 1982-04-28 1986-12-30 Beecham Group Plc Novel chromenes and chromans
EP0095316B1 (en) * 1982-05-21 1986-12-03 Beecham Group Plc Pharmaceutically active aminobenzopyrans
EP0126311B1 (en) * 1983-05-18 1989-09-13 Beecham Group Plc Benzopyran derivatives.

Also Published As

Publication number Publication date
AU569587B2 (en) 1988-02-11
NZ208170A (en) 1987-07-31
ES532591A0 (es) 1985-07-01
GR81588B (es) 1984-12-11
DE3486354T2 (de) 1995-03-30
JPH0631210B2 (ja) 1994-04-27
JPS59219277A (ja) 1984-12-10
EP0126367B1 (en) 1994-10-12
ES541229A0 (es) 1986-01-16
CA1236110A (en) 1988-05-03
DE3486354D1 (de) 1994-11-17
US4575511A (en) 1986-03-11
AU2808084A (en) 1984-11-22
ES8506300A1 (es) 1985-07-01
EP0126367A1 (en) 1984-11-28

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