ATE158303T1 - Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften - Google Patents

Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften

Info

Publication number: ATE158303T1
Authority: AT; Austria
Prior art keywords: ace; hydrogen; amino; nitro compounds; inhibiting properties
Prior art date: 1990-12-21

Application number

AT91121638T

Other languages

English (en)

Inventor

Gary A Flynn

Douglas W Beight

Original Assignee

Merrell Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-17

Publication date

1997-10-15

1991-12-17 Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc

1997-10-15 Application granted granted Critical

1997-10-15 Publication of ATE158303T1 publication Critical patent/ATE158303T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
- C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biophysics (AREA)
Urology & Nephrology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT91121638T 1990-12-21 1991-12-17 Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften ATE158303T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63357290A	1990-12-21	1990-12-21
US77762591A	1991-10-23	1991-10-23

Publications (1)

Publication Number	Publication Date
ATE158303T1 true ATE158303T1 (de)	1997-10-15

Family

ID=27091923

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91121638T ATE158303T1 (de)	1990-12-21	1991-12-17	Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften

Country Status (18)

Country	Link
EP (1)	EP0492369B1 (de)
JP (1)	JP3112327B2 (de)
KR (2)	KR100220880B1 (de)
CN (1)	CN1040985C (de)
AT (1)	ATE158303T1 (de)
AU (1)	AU642321B2 (de)
CA (1)	CA2057786C (de)
DE (1)	DE69127681T2 (de)
DK (1)	DK0492369T3 (de)
ES (1)	ES2108027T3 (de)
FI (1)	FI95800C (de)
GR (1)	GR3025622T3 (de)
HU (1)	HU210167B (de)
IE (1)	IE914507A1 (de)
IL (1)	IL100416A (de)
NO (1)	NO180196C (de)
NZ (1)	NZ241023A (de)
PT (1)	PT99849B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5308841A (en) *	1990-12-21	1994-05-03	Merrell Dow Pharmaceuticals Inc.	Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0534363B1 (de) *	1991-09-27	1997-07-09	Merrell Pharmaceuticals Inc.	2-Substituierte Indan-2-Mercaptoacetylamid-Verbindungen mit Enkephalinase und ACE-Hemmwirkung
AU657793B2 (en) *	1991-09-27	1995-03-23	Merrell Pharmaceuticals Inc.	Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) *	1991-09-27	1995-10-03	Merrell Dow Pharmaceuticals Inc.	Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
ZA927211B (en) *	1991-09-27	1993-03-24	Merrell Dow Pharma	Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
US5457196A (en) *	1991-09-27	1995-10-10	Merrell Dow Pharmaceuticals Inc.	2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2133963C (en) *	1992-05-15	1998-07-07	Gary A. Flynn	Novel mercaptoacetylamido pyridazo[1,2]pyridazine, pyrazolo[1,2]pyridazine, pyridazo[1,2-a][1,2]diazepine and pyrazolo[1,2-a][1,2]diazepine derivatives useful as inhibitors of enkephalinase and ace
PT669936E (pt) *	1992-10-30	2001-04-30	Merrell Pharma Inc	Derivados de lactama biciclica de mercaptoacetilamida uteis como inibidores de encefalinase e de ace
US5362727A (en) *	1993-07-26	1994-11-08	Bristol-Myers Squibb	Substituted azepino[2,1-a]isoquinoline compounds
US5525723A (en) *	1993-11-18	1996-06-11	Bristol-Myers Squibb Co.	Compounds containing a fused multiple ring lactam
ATE177098T1 (de) *	1994-02-14	1999-03-15	Merrell Pharma Inc	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
EP0746566A1 (de) *	1994-02-14	1996-12-11	Merrell Pharmaceuticals Inc.	2 - substituierte Indane - 2 - Mercaptoacetylamide Disulfide Derivate zur Verwendung als Ankephalinase und ACE Hemmstoffe
JPH09508906A (ja) *	1994-02-14	1997-09-09	メレルファーマスーティカルズインコーポレーテッド	エンケファリナーゼ及びａｃｅの阻害剤として有用な新規なメルカプトアセチルアミド１，３，４，５−テトラヒドロベンゾ［ｃ］アゼピン−３−オンジスルフィド誘導体類
AU687984B2 (en) *	1994-02-14	1998-03-05	Merrell Pharmaceuticals Inc.	Novel indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase
US5530013A (en) *	1994-02-14	1996-06-25	American Home Products Corporation	Venlafaxine in the inducement of cognition enhancement
US5484783A (en) *	1994-03-24	1996-01-16	Merrell Dow Pharmaceuticals Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
ES2141923T3 (es) *	1994-03-24	2000-04-01	Merrell Pharma Inc	Uso hipocolesterolemico, antiaterosclerotico e hipotrigliceridemico de derivados aminoacetilmercapto.
US6013645A (en) *	1994-03-24	2000-01-11	Hoechst Marion Roussel, Inc.	Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
ATE190315T1 (de) *	1994-12-21	2000-03-15	Hoechst Marion Roussel Inc	Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon
US5641880A (en) *	1994-12-21	1997-06-24	Hoechst Marion Roussel, Inc.	Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US7078225B2 (en)	2000-06-02	2006-07-18	Nippon Shokubai Co., Ltd.	Method for enzymatically producing an optically active cyanohydrin
GB0119305D0 (en)	2001-04-12	2001-10-03	Aventis Pharma Gmbh	Mercaptoacetylamide derivatives,a process for their preparation and their use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4584294A (en) *	1984-11-07	1986-04-22	Merck & Co., Inc.	Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
CA1337654C (en) *	1986-06-13	1995-11-28	Gary A. Flynn	Fused tricyclic lactams as antihypertensive agents
AU636101B2 (en) *	1987-04-10	1993-04-22	Monash University	1,2,3,4,10,14b-hexahydrodibenzo(c,f)pyrazino-(1,2-a)azepino derivatives and 10-aza, 10-oxa and 10-thia analogues
US4824832A (en) *	1987-12-30	1989-04-25	Merrell Dow Pharmaceuticals Inc.	Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) *	1990-10-18	2002-04-02	Timothy P. Burkholder	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

1991
- 1991-12-17 CA CA002057786A patent/CA2057786C/en not_active Expired - Fee Related
- 1991-12-17 ES ES91121638T patent/ES2108027T3/es not_active Expired - Lifetime
- 1991-12-17 DE DE69127681T patent/DE69127681T2/de not_active Expired - Fee Related
- 1991-12-17 AT AT91121638T patent/ATE158303T1/de not_active IP Right Cessation
- 1991-12-17 AU AU89819/91A patent/AU642321B2/en not_active Ceased
- 1991-12-17 EP EP91121638A patent/EP0492369B1/de not_active Expired - Lifetime
- 1991-12-17 NZ NZ241023A patent/NZ241023A/en unknown
- 1991-12-17 DK DK91121638.0T patent/DK0492369T3/da active
- 1991-12-18 PT PT99849A patent/PT99849B/pt not_active IP Right Cessation
- 1991-12-18 IL IL10041691A patent/IL100416A/en not_active IP Right Cessation
- 1991-12-19 FI FI916017A patent/FI95800C/fi active IP Right Grant
- 1991-12-20 KR KR1019910023702A patent/KR100220880B1/ko not_active IP Right Cessation
- 1991-12-20 NO NO915068A patent/NO180196C/no unknown
- 1991-12-20 CN CN91111735A patent/CN1040985C/zh not_active Expired - Fee Related
- 1991-12-20 HU HU914092A patent/HU210167B/hu not_active IP Right Cessation
- 1991-12-20 JP JP03354999A patent/JP3112327B2/ja not_active Expired - Fee Related
- 1991-12-20 IE IE450791A patent/IE914507A1/en not_active IP Right Cessation
1997
- 1997-12-10 GR GR970403274T patent/GR3025622T3/el unknown
1999
- 1999-03-27 KR KR1019990010649A patent/KR100220879B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL100416A (en)	1995-11-27
FI95800B (fi)	1995-12-15
KR100220880B1 (ko)	1999-09-15
EP0492369B1 (de)	1997-09-17
PT99849A (pt)	1992-11-30
DK0492369T3 (da)	1997-10-13
GR3025622T3 (en)	1998-03-31
IE914507A1 (en)	1992-07-01
CN1062729A (zh)	1992-07-15
KR920012082A (ko)	1992-07-25
HU914092D0 (en)	1992-03-30
CA2057786A1 (en)	1992-06-22
CA2057786C (en)	2002-06-18
AU642321B2 (en)	1993-10-14
JP3112327B2 (ja)	2000-11-27
NO180196B (no)	1996-11-25
NO180196C (no)	1997-03-05
PT99849B (pt)	1999-06-30
FI916017A (fi)	1992-06-22
DE69127681D1 (de)	1997-10-23
IL100416A0 (en)	1992-09-06
KR100220879B1 (ko)	2000-03-15
AU8981991A (en)	1992-06-25
DE69127681T2 (de)	1998-01-15
HUT60271A (en)	1992-08-28
FI916017A0 (fi)	1991-12-19
HU210167B (en)	1995-02-28
ES2108027T3 (es)	1997-12-16
JPH04342588A (ja)	1992-11-30
EP0492369A1 (de)	1992-07-01
FI95800C (fi)	1996-03-25
NO915068D0 (no)	1991-12-20
NZ241023A (en)	1994-10-26
NO915068L (no)	1992-06-22
CN1040985C (zh)	1998-12-02

Publication	Publication Date	Title
ATE158303T1 (de)	1997-10-15	Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften
IS6257A (is)	2002-01-31	Frumuviðloðunartálmar
MY107756A (en)	1996-06-15	Piperazine derivatives.
CA2325741A1 (en)	1999-10-07	Urea derivatives having tnf- .alpha. production inhibitory effects
ES8800269A1 (es)	1987-11-01	Un procedimiento para la preparacion de peptidilaminodioles.
DE69835430D1 (de)	2006-09-14	Sulfonamidderivate, ihre herstellung und verwendung
AU2910600A (en)	2000-08-29	Phenyl urea and phenyl thiourea derivatives
MY101176A (en)	1991-07-31	Heterocyclic compounds as fungicides
TW368501B (en)	1999-09-01	7-(2-aminoethyl)-benzothiazolones
ES2110620T3 (es)	1998-02-16	Derivados de la 4-aza-5-alfa-androstan-3-ona sustituidos en la posicion 17-beta.
CA2379061A1 (en)	2001-02-15	Antibacterial agents
ATE196145T1 (de)	2000-09-15	Phosphonsäurediesterderivate
ES2073258T3 (es)	1995-08-01	Nuevos derivados de la urea, su preparacion y su aplicacion en terapeutica.
ES8205808A1 (es)	1982-08-01	Un procedimiento para la preparacion de nuevos derivados del acido 2-penem-3-carboxilico.
DK0696585T3 (da)	1999-08-23	Nyt bisoxadiazolidinderivat
UA26459C2 (uk)	1999-08-30	Іhгібітор впливу амілоїдhих білків
DE69808326D1 (de)	2002-10-31	Azetidinonderivate zur behandlung von hcmv entzündungen
ATE65986T1 (de)	1991-08-15	Propanolabkoemmlinge.
TR199901102T2 (xx)	1999-10-21	Bisiklik amin t�revleri.

Legal Events

Date	Code	Title	Description
1998-06-15	UEP	Publication of translation of european patent specification
2004-09-15	REN	Ceased due to non-payment of the annual fee