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ATE190315T1 - Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon - Google Patents

Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon

Info

Publication number
ATE190315T1
ATE190315T1 AT95942465T AT95942465T ATE190315T1 AT E190315 T1 ATE190315 T1 AT E190315T1 AT 95942465 T AT95942465 T AT 95942465T AT 95942465 T AT95942465 T AT 95942465T AT E190315 T1 ATE190315 T1 AT E190315T1
Authority
AT
Austria
Prior art keywords
intermediate products
enkephalinase
converting enzyme
enzyme inhibitors
angiotensin converting
Prior art date
Application number
AT95942465T
Other languages
English (en)
Inventor
Gary Alan Flynn
Thomas Delbert Bannister
Michael James Genin
Douglas Wade Beight
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/535,403 external-priority patent/US5641880A/en
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Application granted granted Critical
Publication of ATE190315T1 publication Critical patent/ATE190315T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT95942465T 1994-12-21 1995-11-20 Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon ATE190315T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36091594A 1994-12-21 1994-12-21
US08/535,403 US5641880A (en) 1994-12-21 1995-10-24 Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
PCT/US1995/015225 WO1996019492A1 (en) 1994-12-21 1995-11-20 Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof

Publications (1)

Publication Number Publication Date
ATE190315T1 true ATE190315T1 (de) 2000-03-15

Family

ID=27001069

Family Applications (2)

Application Number Title Priority Date Filing Date
AT95942465T ATE190315T1 (de) 1994-12-21 1995-11-20 Verfahren zur herstellung von zwischenprodukten von inhibitoren der enkephalinase und des angiotensin konvertierenden enzyms und zwischenprodukte davon
AT99114227T ATE266040T1 (de) 1994-12-21 1995-11-20 Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99114227T ATE266040T1 (de) 1994-12-21 1995-11-20 Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon

Country Status (22)

Country Link
US (1) US5734049A (de)
EP (1) EP0800527B1 (de)
JP (1) JP3658408B2 (de)
CN (2) CN1113894C (de)
AR (1) AR000378A1 (de)
AT (2) ATE190315T1 (de)
AU (1) AU689362B2 (de)
CA (2) CA2297134C (de)
DE (2) DE69515517T2 (de)
DK (2) DK0800527T3 (de)
ES (2) ES2216386T3 (de)
FI (1) FI121599B (de)
GR (1) GR3033329T3 (de)
HU (1) HU227675B1 (de)
IL (6) IL139142A (de)
MX (1) MX9704677A (de)
NO (2) NO308900B1 (de)
NZ (2) NZ298245A (de)
PT (2) PT800527E (de)
SI (2) SI0957109T1 (de)
TW (1) TW401413B (de)
WO (1) WO1996019492A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP6169193B2 (ja) * 2013-01-30 2017-07-26 ビーエーエスエフ ソシエタス・ヨーロピアＢａｓｆ Ｓｅ ２，６−ビス（アミノメチル）ピペリジン誘導体

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
CA1337654C (en) * 1986-06-13 1995-11-28 Gary A. Flynn Fused tricyclic lactams as antihypertensive agents
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
EP0492369B1 (de) * 1990-12-21 1997-09-17 Merrell Pharmaceuticals Inc. Neue trizyklische Amino- und Nitro Verbindungen mit ACE-hemmenden Eigenschaften
AU657793B2 (en) * 1991-09-27 1995-03-23 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
CA2078758C (en) * 1991-09-27 2003-12-09 Alan M. Warshawsky 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5525723A (en) * 1993-11-18 1996-06-11 Bristol-Myers Squibb Co. Compounds containing a fused multiple ring lactam

Also Published As

Publication number Publication date
NO308900B1 (no) 2000-11-13
GR3033329T3 (en) 2000-09-29
NZ334608A (en) 1999-07-29
US5734049A (en) 1998-03-31
AR000378A1 (es) 1997-06-18
CN1170413A (zh) 1998-01-14
DE69515517D1 (de) 2000-04-13
TW401413B (en) 2000-08-11
PT800527E (pt) 2000-06-30
JPH10511348A (ja) 1998-11-04
NZ298245A (en) 1999-04-29
SI0957109T1 (en) 2004-10-31
HU227675B1 (en) 2011-11-28
DE69515517T2 (de) 2000-07-06
EP0800527B1 (de) 2000-03-08
DE69533002T2 (de) 2005-05-04
IL139141A (en) 2005-11-20
NO310025B1 (no) 2001-05-07
ATE266040T1 (de) 2004-05-15
CN1113894C (zh) 2003-07-09
NO972875L (no) 1997-08-20
IL128996A0 (en) 2000-02-17
CA2297134C (en) 2004-02-10
CN1241924C (zh) 2006-02-15
EP0800527A1 (de) 1997-10-15
MX9704677A (es) 1997-09-30
IL116428A (en) 2001-03-19
CN1495186A (zh) 2004-05-12
DK0957109T3 (da) 2004-06-01
ES2216386T3 (es) 2004-10-16
IL116428A0 (en) 1996-03-31
AU4368596A (en) 1996-07-10
WO1996019492A1 (en) 1996-06-27
AU689362B2 (en) 1998-03-26
NO20001822L (no) 1997-08-20
PT957109E (pt) 2004-09-30
SI0800527T1 (en) 2000-08-31
IL139142A0 (en) 2001-11-25
ES2147863T3 (es) 2000-10-01
CA2208569A1 (en) 1996-06-27
CA2297134A1 (en) 1996-06-27
FI121599B (fi) 2011-01-31
FI972620L (fi) 1997-06-18
NO972875D0 (no) 1997-06-20
HK1066009A1 (en) 2005-03-11
NO20001822D0 (no) 2000-04-07
DE69533002D1 (de) 2004-06-09
FI972620A0 (fi) 1997-06-18
DK0800527T3 (da) 2000-06-05
IL139141A0 (en) 2001-11-25
HUT78073A (hu) 1999-08-30
CA2208569C (en) 2000-07-11
JP3658408B2 (ja) 2005-06-08
IL139142A (en) 2004-07-25

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UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner