AR060618A1 - Compuesto de ciclohexilpirazol-lactama composicion farmaceutica que comprende dicho compuesto su uso para la preparacion de un medicamento e intermediarios para prepararlo - Google Patents
Compuesto de ciclohexilpirazol-lactama composicion farmaceutica que comprende dicho compuesto su uso para la preparacion de un medicamento e intermediarios para prepararloInfo
- Publication number
- AR060618A1 AR060618A1 ARP070101715A ARP070101715A AR060618A1 AR 060618 A1 AR060618 A1 AR 060618A1 AR P070101715 A ARP070101715 A AR P070101715A AR P070101715 A ARP070101715 A AR P070101715A AR 060618 A1 AR060618 A1 AR 060618A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogens
- optionally substituted
- alkyl
- halogen
- independently
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuesto de ciclohexilpirazol-lactama, de la formula (1) donde: R1 es -H, -halogeno, -O-CH3 (opcionalmente substituido con uno a tres halogenos), o -CH3 (opcionalmente substituido con uno a tres halogenos); R2 es -H, -halogeno, -O-CH3 (opcionalmente substituido con uno a tres halogenos), o -CH3 (opcionalmente substituido con uno a tres halogenos); R3 es -H o -halogeno; R4 es: -OH, -halogeno, -ciano, -alquilo C1-4 (opcionalmente substituido con uno a tres halogenos), -alcoxi C1-6 (opcionalmente substituido con uno a tres halogenos), -SCF3, -C(O)Oalquilo C1-4, -OCH2-C(O)NH2, -cicloalquilo C3-8, -O-fenil-C(O)O-alquilo C1-4, -CH2-fenil, -NHSO2-alquilo C1-4, -NHSO2-fenil(R21)(R21), -alquilo C1-4-C(O)N(R10)(R11), - C(O)N(R10)(R11), formulas (2) en donde la línea punteada representa el punto de enlace en la posicion R4 en la formula 1; en donde m es 1, 2, o 3; en donde n es 0, 1, o 2, y en donde cuando n es 0, luego ô(CH2) nö es un enlace; R5 es -H, -halogeno, - OH, -CN, -alquilo C1-4 (opcionalmente substituido con 1 a 3 halogenos), -C(O)OH, -C(O)O-alquilo C1-4, -C(O)-alquilo C1-4, -O-alquilo C1-4 (opcionalmente substituido con 1 a 3 halogenos), -SO2-alquilo C1-4, -N(R8)(R8), -fenil(R21)(R21), -C(O)-NH- cicloalquilo C3-6, formulas (3) en donde la línea punteada representa el punto de enlace en la posicion indicada por R5; en donde m es 1 2, o 3; en donde n es 0, 1, o 2, y en donde cuando n es 0, luego ô(CH2) nö es un enlace; R6 es -H, -halogeno, - CN, -alquilo C1-4 (opcionalmente substituido con 1 a 3 halogenos), -O-alquilo C1-4 (opcionalmente substituido con 1 a 3 halogenos), o formula (4); R7 es -H, -halogeno, o -alquilo C1-4 (opcionalmente substituido con 1 a 3 halogenos); R8 es independientemente cada que se presenta -H, -alquilo C1-6 (opcionalmente substituido con 1 a 3 halogenos), -C(O)alquilo C1-6 (opcionalmente substituido con 1 a 3 halogenos), -C(O)-cicloalquilo C3-8, -S(O2)- cicloalquilo C3-8 o -S(O2)-alquilo C1-3 (opcionalmente substituido con 1 a 3 halogenos); R9 es -H o -halogeno; R10 y R11 son cada uno independientemente -H o -alquilo C1-4, o R10 y R11 tomados juntos con el nitrogeno al cual se enlazan forman piperidinilo, piperazinilo, o pirrolidinilo; R20 es independientemente cada que se presenta -H, o -alquilo C1-3 (opcionalmente substituido con 1 a 3 halogenos); R21 es independientemente cada que se presenta -H, -halogeno, o -alquilo C1-3 (opcionalmente substituido con 1 a 3 halogenos); R22 es independientemente cada que se presenta -H o - alquilo C1-6 (opcionalmente substituido con 1 a 3 halogenos); y R23 es independientemente cada que se presenta -H, -alquilo C1-4, o -C(O)O-alquilo C1-4; o un estereoisomero del mismo; o una sal farmacéuticamente aceptable del mismo. Composicion farmacéutica que lo comprende. Su uso para preparar un medicamento util para tratar síndromes metabolicos, diabetes tipo 2 o arterosclerosis y otras condiciones asociadas con la actividad 11 beta- HSD de tipo 1. Intermediarios para preparar el compuesto (3R)-3-[3,5-Dicloro-4'-fluoro[1,1'-bifenil]-4-iI)metil]-1-[(5S)4,5,6,7-tetrahidro-1H-indazol-5-iI]-2-pirrolidinona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74532006P | 2006-04-21 | 2006-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060618A1 true AR060618A1 (es) | 2008-07-02 |
Family
ID=38595048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101715A AR060618A1 (es) | 2006-04-21 | 2007-04-20 | Compuesto de ciclohexilpirazol-lactama composicion farmaceutica que comprende dicho compuesto su uso para la preparacion de un medicamento e intermediarios para prepararlo |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7981918B2 (es) |
| EP (1) | EP2029579B1 (es) |
| JP (1) | JP5161869B2 (es) |
| KR (1) | KR101055576B1 (es) |
| CN (1) | CN101426783B (es) |
| AR (1) | AR060618A1 (es) |
| AU (1) | AU2007240550B2 (es) |
| BR (1) | BRPI0710229A2 (es) |
| CA (1) | CA2647677C (es) |
| CO (1) | CO6140026A2 (es) |
| CR (1) | CR10400A (es) |
| DO (1) | DOP2007000078A (es) |
| EA (1) | EA015675B1 (es) |
| EC (1) | ECSP088839A (es) |
| ES (1) | ES2533263T3 (es) |
| HK (1) | HK1126493A1 (es) |
| IL (1) | IL194835A (es) |
| JO (1) | JO3042B1 (es) |
| MA (1) | MA30476B1 (es) |
| MX (1) | MX2008013484A (es) |
| MY (1) | MY148128A (es) |
| NO (1) | NO20084403L (es) |
| NZ (1) | NZ571175A (es) |
| PE (1) | PE20080362A1 (es) |
| SV (1) | SV2008003070A (es) |
| TN (1) | TNSN08405A1 (es) |
| TW (1) | TWI347321B (es) |
| UA (1) | UA95798C2 (es) |
| WO (1) | WO2007124254A2 (es) |
| ZA (1) | ZA200808686B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007124329A1 (en) | 2006-04-21 | 2007-11-01 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US8088776B2 (en) | 2006-04-21 | 2012-01-03 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US8153807B2 (en) | 2006-04-24 | 2012-04-10 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127704A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127693A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| PL2021337T3 (pl) | 2006-04-25 | 2010-06-30 | Lilly Co Eli | Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| MX2008013656A (es) * | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| DE602007007211D1 (de) | 2006-04-25 | 2010-07-29 | Lilly Co Eli | Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1 |
| SI2049513T1 (sl) | 2006-04-28 | 2012-04-30 | Lilly Co Eli | Piperidinil substituirani pirolidinoni kot inhibitorji 11-betahidroksisteroid dehidrogenaze 1 |
| US8835426B2 (en) | 2007-02-26 | 2014-09-16 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1 |
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AR069207A1 (es) | 2007-11-07 | 2010-01-06 | Vitae Pharmaceuticals Inc | Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1 |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| WO2009134400A1 (en) | 2008-05-01 | 2009-11-05 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010011314A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1 |
| EP2324017B1 (en) | 2008-07-25 | 2014-12-31 | Boehringer Ingelheim International GmbH | INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1 |
| EP2323994A1 (en) | 2008-07-25 | 2011-05-25 | Boehringer Ingelheim International GmbH | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| WO2010089303A1 (en) | 2009-02-04 | 2010-08-12 | Boehringer Ingelheim International Gmbh | CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1 |
| WO2010091067A2 (en) * | 2009-02-04 | 2010-08-12 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| US8680093B2 (en) | 2009-04-30 | 2014-03-25 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2011011123A1 (en) | 2009-06-11 | 2011-01-27 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure |
| EP2448928B1 (en) | 2009-07-01 | 2014-08-13 | Vitae Pharmaceuticals, Inc. | Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| US8552212B2 (en) | 2009-11-05 | 2013-10-08 | Boehringer Ingelheim International Gmbh | Chiral phosphorus ligands |
| US8871208B2 (en) * | 2009-12-04 | 2014-10-28 | Abbvie Inc. | 11-β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and uses thereof |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| JP2013531636A (ja) | 2010-05-26 | 2013-08-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ２−オキソ−１，２−ジヒドロピリジン−４−イルボロン酸誘導体 |
| US8933072B2 (en) | 2010-06-16 | 2015-01-13 | Vitae Pharmaceuticals, Inc. | Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| WO2011161128A1 (en) | 2010-06-25 | 2011-12-29 | Boehringer Ingelheim International Gmbh | Azaspirohexanones as inhibitors of 11-beta-hsd1 for the treatment of metabolic disorders |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| BR112013010021A2 (pt) | 2010-11-02 | 2019-09-24 | Boehringer Ingelheim Int | combinações farmacêuticas para o tratamento de distúrbios metabólicos. |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| TWI545113B (zh) | 2011-10-18 | 2016-08-11 | 安斯泰來製藥股份有限公司 | 二環式雜環化合物 |
| AR099936A1 (es) * | 2014-04-04 | 2016-08-31 | Sanofi Sa | Heterociclos condensados sustituidos como moduladores de gpr119 para el tratamiento de la diabetes, obesidad, dislipidemia y trastornos relacionados |
| US10858347B2 (en) | 2015-12-31 | 2020-12-08 | Karyopharm Therapeutics Inc. | Multicyclic compounds and uses thereof |
| AU2022224918B2 (en) | 2021-02-25 | 2023-04-13 | Aptabio Therapeutics Inc. | Novel pyrazole derivatives |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056744A1 (en) | 2002-12-23 | 2004-07-08 | Janssen Pharmaceutica N.V. | Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors |
| CN101001836B (zh) * | 2004-05-07 | 2010-12-22 | 詹森药业有限公司 | 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物 |
| KR101193464B1 (ko) | 2004-05-07 | 2012-10-24 | 얀센 파마슈티카 엔.브이. | １１-베타 하이드록시스테로이드 탈수소효소 저해제로서의아다만틸 피롤리딘-２-온 유도체 |
| EP1802623A1 (en) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| ES2318577T3 (es) | 2004-10-29 | 2009-05-01 | Eli Lilly And Company | Derivados de cicloalquil lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1'. |
| NZ554906A (en) | 2004-11-10 | 2011-01-28 | Incyte Corp | Lactam compounds and their use as pharmaceuticals |
| US20080214621A1 (en) | 2004-12-20 | 2008-09-04 | Thomas Daniel Aicher | Cycloalkyl Lactam Derivatives As Inhibitors Of 11-Beta-Hydroxysteroid Dehydrogenase 1 |
| US7834194B2 (en) | 2004-12-21 | 2010-11-16 | Eli Lilly And Company | Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US20090264650A1 (en) | 2005-03-31 | 2009-10-22 | Nobuo Cho | Prophylactic/Therapeutic Agent for Diabetes |
| ES2322727B1 (es) | 2005-07-28 | 2010-04-22 | Universidad Del Pais Vasco | Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares. |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| WO2007124329A1 (en) | 2006-04-21 | 2007-11-01 | Eli Lilly And Company | Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US8088776B2 (en) | 2006-04-21 | 2012-01-03 | Eli Lilly And Company | Biphenyl amide lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127693A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| US8153807B2 (en) | 2006-04-24 | 2012-04-10 | Eli Lilly And Company | Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| WO2007127704A1 (en) | 2006-04-24 | 2007-11-08 | Eli Lilly And Company | Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1 |
| MX2008013656A (es) | 2006-04-25 | 2008-11-10 | Lilly Co Eli | Inhibidores de 11-beta-hidroxiesteroide deshidrogenasa. |
| DE602007007211D1 (de) | 2006-04-25 | 2010-07-29 | Lilly Co Eli | Inhibitoren von11-beta-hydroxysteroiddehydrogenase 1 |
| PL2021337T3 (pl) | 2006-04-25 | 2010-06-30 | Lilly Co Eli | Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1 |
| SI2049513T1 (sl) | 2006-04-28 | 2012-04-30 | Lilly Co Eli | Piperidinil substituirani pirolidinoni kot inhibitorji 11-betahidroksisteroid dehidrogenaze 1 |
| CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
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2007
- 2007-04-05 NZ NZ571175A patent/NZ571175A/en not_active IP Right Cessation
- 2007-04-05 MY MYPI20084205A patent/MY148128A/en unknown
- 2007-04-05 JP JP2009506680A patent/JP5161869B2/ja not_active Expired - Fee Related
- 2007-04-05 CN CN2007800142829A patent/CN101426783B/zh not_active Expired - Fee Related
- 2007-04-05 MX MX2008013484A patent/MX2008013484A/es active IP Right Grant
- 2007-04-05 ES ES07760191.2T patent/ES2533263T3/es active Active
- 2007-04-05 EA EA200870460A patent/EA015675B1/ru not_active IP Right Cessation
- 2007-04-05 AU AU2007240550A patent/AU2007240550B2/en not_active Ceased
- 2007-04-05 BR BRPI0710229-1A patent/BRPI0710229A2/pt active Search and Examination
- 2007-04-05 UA UAA200812290A patent/UA95798C2/ru unknown
- 2007-04-05 KR KR1020087025618A patent/KR101055576B1/ko not_active IP Right Cessation
- 2007-04-05 US US12/297,375 patent/US7981918B2/en not_active Expired - Fee Related
- 2007-04-05 WO PCT/US2007/066069 patent/WO2007124254A2/en active Application Filing
- 2007-04-05 CA CA2647677A patent/CA2647677C/en not_active Expired - Fee Related
- 2007-04-05 EP EP07760191.2A patent/EP2029579B1/en active Active
- 2007-04-18 JO JOP/2007/0149A patent/JO3042B1/ar active
- 2007-04-19 TW TW096113852A patent/TWI347321B/zh not_active IP Right Cessation
- 2007-04-19 DO DO2007000078A patent/DOP2007000078A/es unknown
- 2007-04-20 AR ARP070101715A patent/AR060618A1/es not_active Application Discontinuation
- 2007-04-20 PE PE2007000491A patent/PE20080362A1/es not_active Application Discontinuation
-
2008
- 2008-10-10 ZA ZA200808686A patent/ZA200808686B/xx unknown
- 2008-10-17 CO CO08110816A patent/CO6140026A2/es unknown
- 2008-10-17 TN TNP2008000405A patent/TNSN08405A1/en unknown
- 2008-10-20 NO NO20084403A patent/NO20084403L/no not_active Application Discontinuation
- 2008-10-21 EC EC2008008839A patent/ECSP088839A/es unknown
- 2008-10-21 SV SV2008003070A patent/SV2008003070A/es unknown
- 2008-10-22 IL IL194835A patent/IL194835A/en not_active IP Right Cessation
- 2008-10-24 CR CR10400A patent/CR10400A/es unknown
- 2008-11-20 MA MA31396A patent/MA30476B1/fr unknown
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2009
- 2009-06-17 HK HK09105407.7A patent/HK1126493A1/xx not_active IP Right Cessation
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