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AR083879A1 - Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos - Google Patents

Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos

Info

Publication number
AR083879A1
AR083879A1 ARP110104258A ARP110104258A AR083879A1 AR 083879 A1 AR083879 A1 AR 083879A1 AR P110104258 A ARP110104258 A AR P110104258A AR P110104258 A ARP110104258 A AR P110104258A AR 083879 A1 AR083879 A1 AR 083879A1
Authority
AR
Argentina
Prior art keywords
preparation
antibacterial
methods
aminoglycosid
analogs
Prior art date
Application number
ARP110104258A
Other languages
English (en)
Inventor
James Bradley Aggen
Martin Sheringham Linsell
Darin James Hildebrandt
Micah James Gliedt
Paola Dozzo
Adam Aaron Goldblum
Timothy Robert Kane
Original Assignee
Achaogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achaogen Inc filed Critical Achaogen Inc
Publication of AR083879A1 publication Critical patent/AR083879A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Se presentan compuestos que tienen actividad antibacteriana. También se presentan los métodos asociados con la preparación y uso de dichos compuestos, así como también las composiciones farmacéuticas que comprenden dichos compuestos.Reivindicación 1: Un compuesto que tiene la estructura de fórmula (1), o un estereoisómero, prodroga o sal del mismo aceptable desde el punto de vista farmacéutico, caracterizado porque: Q1 es -NHR1; Q2 es el resto de fórmula (2); R1 es alquilo C2-6 sustituido con por lo menos un hidroxilo; R2 es hidrógeno o alquilo C1-6 opcionalmente sustituido con uno o más de halógeno, hidroxilo o amino; y n es un entero desde 1 hasta 4.
ARP110104258A 2010-11-17 2011-11-14 Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos AR083879A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41476210P 2010-11-17 2010-11-17
US201161505371P 2011-07-07 2011-07-07

Publications (1)

Publication Number Publication Date
AR083879A1 true AR083879A1 (es) 2013-03-27

Family

ID=45099181

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110104258A AR083879A1 (es) 2010-11-17 2011-11-14 Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos

Country Status (7)

Country Link
US (2) US8318685B2 (es)
EP (1) EP2640735A1 (es)
JP (1) JP2013542992A (es)
CN (1) CN103282370A (es)
AR (1) AR083879A1 (es)
TW (1) TW201304784A (es)
WO (1) WO2012067978A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007064954A2 (en) 2005-12-02 2007-06-07 Isis Pharmaceuticals, Inc. Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
CN101715455A (zh) * 2007-04-10 2010-05-26 尔察祯有限公司 抗菌的1,4,5-取代的氨基糖苷类似物
LT2217610T (lt) 2007-11-21 2017-02-27 Achaogen, Inc. Antibakteriniai aminoglikozidų analogai
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
EP2486044A2 (en) 2009-10-09 2012-08-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
AR083879A1 (es) * 2010-11-17 2013-03-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos
WO2019046126A1 (en) * 2017-08-28 2019-03-07 Achaogen, Inc. AMINOGLYCOSIDES AND USES THEREOF
US11673907B2 (en) 2018-04-03 2023-06-13 Revagenix, Inc. Modular synthesis of aminoglycosides

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WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
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AR083879A1 (es) 2010-11-17 2013-03-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos, metodos de preparacion y uso como agentes terapeuticos

Also Published As

Publication number Publication date
US20130178438A1 (en) 2013-07-11
TW201304784A (zh) 2013-02-01
EP2640735A1 (en) 2013-09-25
WO2012067978A1 (en) 2012-05-24
JP2013542992A (ja) 2013-11-28
US20120122809A1 (en) 2012-05-17
CN103282370A (zh) 2013-09-04
US8318685B2 (en) 2012-11-27
US8653041B2 (en) 2014-02-18

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