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AR045471A1 - Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre - Google Patents

Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre

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Publication number
AR045471A1
AR045471A1 ARP040102991A ARP040102991A AR045471A1 AR 045471 A1 AR045471 A1 AR 045471A1 AR P040102991 A ARP040102991 A AR P040102991A AR P040102991 A ARP040102991 A AR P040102991A AR 045471 A1 AR045471 A1 AR 045471A1
Authority
AR
Argentina
Prior art keywords
substituted
group
nr4r5
heterocycle
aryl
Prior art date
Application number
ARP040102991A
Other languages
English (en)
Inventor
Jagadish Sircar
K C Sunil Kumar
Wenbin Ying
Original Assignee
Avanir Pharmaceuticals
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR045471(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Avanir Pharmaceuticals filed Critical Avanir Pharmaceuticals
Publication of AR045471A1 publication Critical patent/AR045471A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pulmonology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
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  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
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Abstract

Se proveen inhibidores del factor inhibidor de la migración de macrófagos (MIF) con una estructura principal de naftiridina que son de utilidad en el tratamiento de una variedad de trastornos, incluyendo el tratamiento de afecciones patológicas asociadas con la actividad del MIF. Los inhibidores del MIF tienen las estructuras de las fórmulas (1), que incluyen estereoisómeros, prodrogas y sales aceptables para uso farmacéutico de los mismos. También se proveen composiciones que contienen un inhibidor de MIF en combinación con un vehículo aceptable para uso farmacéutico, así como métodos para utilizarlos. Reivindicación 1: Un compuesto donde, R se selecciona entre el grupo que consiste en hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, acilalquilo, acilalquilo sustituido, heterociclo, heterociclo sustituido, -(CH2)mC(=O)Ar, y -(CH2)mNR4R5; R1 se selecciona entre el grupo que consiste en -CN, -NO, -NO2, -C(=O)R3, -C(=O)OH, -NHC(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -SO2NR4R5, -NR3SO2R3, -NHSO2R3, -S(O)mR3, -(CH2)mNR4R5, y -(CH2)mC(=O)Ar; R2 se selecciona entre el grupo que consiste en - CH2R3, -NR4R5, -OR3, y -R3; R3 se selecciona independientemente entre el grupo que consiste en alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, acilalquilo, acilalquilo sustituido, heterociclo, heterociclo sustituido; R4 y R5 se seleccionan independientemente entre el grupo que consiste en hidrógeno, alquilo, alquilo sustituido, alquenilo, alquenilo sustituido, cicloalquilo, cicloalquilo sustituido, arilo, arilo sustituido, arilalquilo, arilalquilo sustituido, acilalquilo, acilalquilo sustituido, heterociclo, y heterociclo sustituido, o R4 y R5 tomados juntos comprenden heterociclo o heterociclo sustituido; X se selecciona entre el grupo que consiste en hidrógeno, halógeno, -F, -Cl, -CN, -NO, -NO2, -OCF3, -CF3, -NHSO2R3, -C(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -NR3SO2R3, -S(O)mR3, -R3, -OR3, -SR3, -C(=O)OH, -NHC(=O)R3, y -NR4R5; Y se selecciona entre el grupo que consiste en hidrógeno, halógeno, -F, -Cl, -CN, -NO, -NO2, -OCF3, -CF3, -NHSO2R3, -C(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -NR3SO2R3, -S(O)mR3, -R3, -OR3, -SR3, -C(=O)OH, -NHC(=O)R3, y -NR4R5; Z se selecciona entre el grupo que consiste en hidrógeno, halógeno, -F, -Cl, -CN, -NO, -NO2, -OCF3, -CF3, -NHSO2R3, -C(=O)R3, -C(=O)OR3, -C(=O)NR4R5, -NR3C(=O)R3, -NR3SO2R3, -S(O)mR3, -R3, -OR3, -SR3, -C(=O)OH, -NHC(=O)R3, y -NR4R5; Ar se selecciona entre el grupo que consiste en arilo y arilo sustituido; m es independientemente 0, 1, 2, 3 ó 4; y n es 0, 1 ó 2.
ARP040102991A 2003-08-22 2004-08-20 Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre AR045471A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49744303P 2003-08-22 2003-08-22

Publications (1)

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AR045471A1 true AR045471A1 (es) 2005-10-26

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ID=34272569

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Application Number Title Priority Date Filing Date
ARP040102991A AR045471A1 (es) 2003-08-22 2004-08-20 Derivados de naftiridina sustituidos como inhibidores del factor inhibidor de la migracion de macrofagos y su uso en el tratamiento de enfermedades en el hombre

Country Status (13)

Country Link
US (2) US20050124604A1 (es)
EP (1) EP1656376A1 (es)
JP (1) JP2007503388A (es)
CN (1) CN1839133A (es)
AR (1) AR045471A1 (es)
AU (1) AU2004268941A1 (es)
BR (1) BRPI0413695A (es)
CA (1) CA2531506A1 (es)
MX (1) MXJL06000006A (es)
PE (1) PE20051112A1 (es)
TW (1) TW200524928A (es)
UY (1) UY28483A1 (es)
WO (1) WO2005021546A1 (es)

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CN1839133A (zh) 2006-09-27
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US20070191388A1 (en) 2007-08-16
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