AP1689A - N-phenpropylclopentyl-substituted glutaramide derivatives as nep inhibitors for FSAD. - Google Patents

N-phenpropylclopentyl-substituted glutaramide derivatives as nep inhibitors for FSAD.

Info

Publication number: AP1689A
Authority: AP; ARIPO
Prior art keywords: optionally substituted; phenpropylclopentyl; fsad; substituted; nep inhibitors
Prior art date: 2001-03-28

Application number

APAP/P/2002/002467A

Other languages

English (en)

Other versions

AP2002002467A0 (en

Inventor

Stephen Challenger

Andrew Simon Cook

Adam Thomas Gillmore

Donald Stuart Middleton

David Cameron Pryde

Alan STROBIE

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-03-28

Filing date

2002-03-28

Publication date

2006-12-07

2001-03-28 Priority claimed from GB0107750A external-priority patent/GB0107750D0/en

2001-05-30 Priority claimed from GB0113112A external-priority patent/GB0113112D0/en

2001-08-17 Priority claimed from GB0120152A external-priority patent/GB0120152D0/en

2002-03-28 Application filed by Pfizer filed Critical Pfizer

2002-06-30 Publication of AP2002002467A0 publication Critical patent/AP2002002467A0/xx

2006-12-07 Application granted granted Critical

2006-12-07 Publication of AP1689A publication Critical patent/AP1689A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
- C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/74—Benzo[b]pyrans, hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Gynecology & Obstetrics (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Dispersion Chemistry (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Quinoline Compounds (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

APAP/P/2002/002467A 2001-03-28 2002-03-28 N-phenpropylclopentyl-substituted glutaramide derivatives as nep inhibitors for FSAD. AP1689A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB0107750A GB0107750D0 (en)	2001-03-28	2001-03-28	Novel pharmaceuticals
GB0113112A GB0113112D0 (en)	2001-05-30	2001-05-30	Novel pharmaceuticals
GB0120152A GB0120152D0 (en)	2001-08-17	2001-08-17	Novel pharmaceuticals

Publications (2)

Publication Number	Publication Date
AP2002002467A0 AP2002002467A0 (en)	2002-06-30
AP1689A true AP1689A (en)	2006-12-07

Family

ID=27256128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/2002/002467A AP1689A (en)	2001-03-28	2002-03-28	N-phenpropylclopentyl-substituted glutaramide derivatives as nep inhibitors for FSAD.

Country Status (34)

Country	Link
EP (1)	EP1373192A1 (ko)
JP (1)	JP4018545B2 (ko)
KR (1)	KR100564466B1 (ko)
CN (1)	CN1243723C (ko)
AP (1)	AP1689A (ko)
AR (1)	AR035795A1 (ko)
BG (1)	BG108130A (ko)
BR (1)	BR0208455A (ko)
CA (1)	CA2437113A1 (ko)
CZ (1)	CZ20032534A3 (ko)
DO (1)	DOP2002000364A (ko)
EA (1)	EA006154B1 (ko)
EE (1)	EE200300469A (ko)
GE (1)	GEP20063783B (ko)
HK (1)	HK1060724A1 (ko)
HR (1)	HRP20030751A2 (ko)
HU (1)	HUP0303624A3 (ko)
IL (1)	IL157009A0 (ko)
IS (1)	IS6877A (ko)
MA (1)	MA26996A1 (ko)
MX (1)	MXPA03006597A (ko)
MY (1)	MY134081A (ko)
NO (1)	NO20034299L (ko)
NZ (1)	NZ527012A (ko)
OA (1)	OA12553A (ko)
PA (1)	PA8542401A1 (ko)
PE (1)	PE20021014A1 (ko)
PL (1)	PL365101A1 (ko)
RS (1)	RS75303A (ko)
SK (1)	SK11822003A3 (ko)
TN (1)	TNSN02032A1 (ko)
TW (1)	TWI254038B (ko)
UY (1)	UY27227A1 (ko)
WO (1)	WO2002079143A1 (ko)

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CA2626134C (en)	2005-10-29	2013-12-24	Boehringer Ingelheim International Gmbh	Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
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DE602007004615D1 (de)	2006-06-30	2010-03-18	Boehringer Ingelheim Pharma	Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen
EA200900264A1 (ru)	2006-08-14	2009-08-28	Бёрингер Ингельхайм Интернациональ Гмбх	Композиции флибансерина и способ их приготовления
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EP1925307A1 (en)	2006-11-03	2008-05-28	Emotional Brain B.V.	Use of 3-alpha-androstanediol in the treatment of sexual dysfunction
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US8877815B2 (en)	2010-11-16	2014-11-04	Novartis Ag	Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
US8993631B2 (en)	2010-11-16	2015-03-31	Novartis Ag	Method of treating contrast-induced nephropathy
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2002
- 2002-03-18 IL IL15700902A patent/IL157009A0/xx unknown
- 2002-03-18 CZ CZ20032534A patent/CZ20032534A3/cs unknown
- 2002-03-18 JP JP2002577770A patent/JP4018545B2/ja not_active Expired - Fee Related
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- 2002-03-18 CA CA002437113A patent/CA2437113A1/en not_active Abandoned
- 2002-03-18 CN CNB028054091A patent/CN1243723C/zh not_active Expired - Fee Related
- 2002-03-18 EA EA200300777A patent/EA006154B1/ru unknown
- 2002-03-18 EP EP02707042A patent/EP1373192A1/en not_active Withdrawn
- 2002-03-18 WO PCT/IB2002/000807 patent/WO2002079143A1/en active IP Right Grant
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- 2002-03-18 KR KR1020037012690A patent/KR100564466B1/ko not_active IP Right Cessation
- 2002-03-18 BR BR0208455-4A patent/BR0208455A/pt not_active IP Right Cessation
- 2002-03-18 HU HU0303624A patent/HUP0303624A3/hu unknown
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- 2002-03-18 RS YU75303A patent/RS75303A/sr unknown
- 2002-03-18 NZ NZ527012A patent/NZ527012A/en unknown
- 2002-03-18 MX MXPA03006597A patent/MXPA03006597A/es active IP Right Grant
- 2002-03-18 PL PL02365101A patent/PL365101A1/xx not_active Application Discontinuation
- 2002-03-22 TW TW091105650A patent/TWI254038B/zh not_active IP Right Cessation
- 2002-03-25 UY UY27227A patent/UY27227A1/es not_active Application Discontinuation
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- 2002-03-26 PE PE2002000240A patent/PE20021014A1/es not_active Application Discontinuation
- 2002-03-26 AR ARP020101114A patent/AR035795A1/es unknown
- 2002-03-27 TN TNTNSN02032A patent/TNSN02032A1/fr unknown
- 2002-03-27 PA PA20028542401A patent/PA8542401A1/es unknown
- 2002-03-28 AP APAP/P/2002/002467A patent/AP1689A/en active
2003
- 2003-07-17 IS IS6877A patent/IS6877A/is unknown
- 2003-08-13 MA MA27280A patent/MA26996A1/fr unknown
- 2003-08-25 BG BG108130A patent/BG108130A/bg unknown
- 2003-09-17 HR HR20030751A patent/HRP20030751A2/xx not_active Application Discontinuation
- 2003-09-26 NO NO20034299A patent/NO20034299L/no not_active Application Discontinuation
2004
- 2004-05-25 HK HK04103713A patent/HK1060724A1/xx not_active IP Right Cessation

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Also Published As

Publication number	Publication date
DOP2002000364A (es)	2002-10-15
PE20021014A1 (es)	2002-11-12
NO20034299L (no)	2003-11-27
HK1060724A1 (en)	2004-08-20
HRP20030751A2 (en)	2005-08-31
JP4018545B2 (ja)	2007-12-05
CN1243723C (zh)	2006-03-01
HUP0303624A3 (en)	2005-06-28
CN1492852A (zh)	2004-04-28
NO20034299D0 (no)	2003-09-26
PA8542401A1 (es)	2002-10-28
CZ20032534A3 (cs)	2004-07-14
TWI254038B (en)	2006-05-01
IL157009A0 (en)	2004-02-08
KR20030092032A (ko)	2003-12-03
BG108130A (bg)	2004-07-30
EA006154B1 (ru)	2005-10-27
SK11822003A3 (sk)	2004-09-08
PL365101A1 (en)	2004-12-27
WO2002079143A1 (en)	2002-10-10
EA200300777A1 (ru)	2003-12-25
HUP0303624A2 (hu)	2004-03-01
EP1373192A1 (en)	2004-01-02
BR0208455A (pt)	2004-03-02
JP2004531505A (ja)	2004-10-14
AP2002002467A0 (en)	2002-06-30
UY27227A1 (es)	2002-10-31
RS75303A (en)	2006-12-15
MA26996A1 (fr)	2004-12-20
IS6877A (is)	2003-07-17
CA2437113A1 (en)	2002-10-10
AR035795A1 (es)	2004-07-14
OA12553A (en)	2006-06-07
MY134081A (en)	2007-11-30
TNSN02032A1 (fr)	2005-12-23
GEP20063783B (en)	2006-04-10
NZ527012A (en)	2005-03-24
KR100564466B1 (ko)	2006-03-29
MXPA03006597A (es)	2004-10-15
EE200300469A (et)	2004-02-16

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