NO824398L - 1,4-tiazankarboksylsyrederivater, fremstilling og bruk av disse og blandinger hvori disse derivater er tilstede - Google Patents

1,4-tiazankarboksylsyrederivater, fremstilling og bruk av disse og blandinger hvori disse derivater er tilstede

Info

Publication number: NO824398L
Authority: NO; Norway
Prior art keywords: group; derivative; formula; branched; straight
Prior art date: 1981-04-29

Application number

NO824398A

Other languages

English (en)

Norwegian (no)

Inventor

Joseph Roba

Claude Gillet

Michel Snyers

Georges Lambelin

Original Assignee

Midit

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-29

Filing date

1982-12-28

Publication date

1982-12-28

1982-12-28 Application filed by Midit filed Critical Midit

1982-12-28 Publication of NO824398L publication Critical patent/NO824398L/no

Links

239000000203 mixture Substances 0.000 title claims description 68
238000002360 preparation method Methods 0.000 title claims description 5
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239000000243 solution Substances 0.000 claims description 63
238000000034 method Methods 0.000 claims description 46
239000002253 acid Substances 0.000 claims description 44
229910052739 hydrogen Inorganic materials 0.000 claims description 38
239000001257 hydrogen Substances 0.000 claims description 38
-1 3-phthalidyloxy group Chemical group 0.000 claims description 27
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 26
125000000217 alkyl group Chemical group 0.000 claims description 26
150000001875 compounds Chemical class 0.000 claims description 19
150000003839 salts Chemical class 0.000 claims description 19
ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 18
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 17
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 13
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 13
229910052794 bromium Inorganic materials 0.000 claims description 13
239000002585 base Substances 0.000 claims description 12
239000000460 chlorine Substances 0.000 claims description 12
229910052801 chlorine Inorganic materials 0.000 claims description 12
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 11
150000001412 amines Chemical class 0.000 claims description 11
125000005843 halogen group Chemical group 0.000 claims description 11
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 10
150000002431 hydrogen Chemical class 0.000 claims description 10
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 10
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QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 8
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 7
238000007254 oxidation reaction Methods 0.000 claims description 7
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238000007363 ring formation reaction Methods 0.000 claims description 7
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JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 claims description 6
239000003795 chemical substances by application Substances 0.000 claims description 6
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229910052799 carbon Inorganic materials 0.000 claims description 5
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical group O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 claims description 5
PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 5
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UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 5
125000001424 substituent group Chemical group 0.000 claims description 5
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230000002378 acidificating effect Effects 0.000 claims description 4
150000007513 acids Chemical class 0.000 claims description 4
238000005886 esterification reaction Methods 0.000 claims description 4
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230000007062 hydrolysis Effects 0.000 claims description 4
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125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 4
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239000011591 potassium Substances 0.000 claims description 4
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150000003462 sulfoxides Chemical class 0.000 claims description 4
BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 claims description 4
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims description 4
206010047249 Venous thrombosis Diseases 0.000 claims description 3
150000008044 alkali metal hydroxides Chemical class 0.000 claims description 3
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WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 2
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NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
125000002252 acyl group Chemical group 0.000 claims description 2
239000000654 additive Substances 0.000 claims description 2
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238000004220 aggregation Methods 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
238000007098 aminolysis reaction Methods 0.000 claims description 2
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LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims description 2
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239000008187 granular material Substances 0.000 claims description 2
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238000002347 injection Methods 0.000 claims description 2
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239000011630 iodine Substances 0.000 claims description 2
229910052740 iodine Inorganic materials 0.000 claims description 2
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239000007800 oxidant agent Substances 0.000 claims description 2
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239000000312 peanut oil Substances 0.000 claims description 2
239000011734 sodium Substances 0.000 claims description 2
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239000008223 sterile water Substances 0.000 claims description 2
229910052717 sulfur Inorganic materials 0.000 claims description 2
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150000001735 carboxylic acids Chemical group 0.000 claims 3
206010003178 Arterial thrombosis Diseases 0.000 claims 2
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239000000543 intermediate Substances 0.000 claims 2
230000002265 prevention Effects 0.000 claims 2
QEQYAQFYVFRGQD-YFKPBYRVSA-N (2s)-2-amino-5-[[methyl(nitroso)carbamoyl]amino]pentanoic acid Chemical compound O=NN(C)C(=O)NCCC[C@H](N)C(O)=O QEQYAQFYVFRGQD-YFKPBYRVSA-N 0.000 claims 1
MSTFRUQNYRRUKZ-UHFFFAOYSA-N 5,6-dihydro-2h-thiazine Chemical class C1CC=CNS1 MSTFRUQNYRRUKZ-UHFFFAOYSA-N 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
238000006136 alcoholysis reaction Methods 0.000 claims 1
230000009435 amidation Effects 0.000 claims 1
238000007112 amidation reaction Methods 0.000 claims 1
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
125000000753 cycloalkyl group Chemical group 0.000 claims 1
239000003814 drug Substances 0.000 claims 1
125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
229940124597 therapeutic agent Drugs 0.000 claims 1
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- C—CHEMISTRY; METALLURGY
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
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- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
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- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Hematology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Facsimiles In General (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NO824398A 1981-04-29 1982-12-28 1,4-tiazankarboksylsyrederivater, fremstilling og bruk av disse og blandinger hvori disse derivater er tilstede NO824398L (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
LU83327A LU83327A1 (fr)	1981-04-29	1981-04-29	Procede de preparation de derives de 1,4-thiazine,leur utilisation ainsi que compositions contenant ces derives

Publications (1)

Publication Number	Publication Date
NO824398L true NO824398L (no)	1982-12-28

Family

ID=19729637

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO824398A NO824398L (no)	1981-04-29	1982-12-28	1,4-tiazankarboksylsyrederivater, fremstilling og bruk av disse og blandinger hvori disse derivater er tilstede

Country Status (16)

Country	Link
JP (1)	JPS58500713A (fi)
KR (1)	KR830010089A (fi)
BE (1)	BE893025A (fi)
ES (1)	ES511759A0 (fi)
FI (1)	FI66366C (fi)
FR (1)	FR2509303A1 (fi)
GB (1)	GB2111056B (fi)
GR (1)	GR75996B (fi)
IT (1)	IT1190794B (fi)
LU (1)	LU83327A1 (fi)
NL (1)	NL8220153A (fi)
NO (1)	NO824398L (fi)
PT (1)	PT74813B (fi)
SE (1)	SE8207294L (fi)
WO (1)	WO1982003860A1 (fi)
ZA (1)	ZA822926B (fi)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3436386A1 (de) *	1984-10-04	1986-04-10	Merck Patent Gmbh, 6100 Darmstadt	(thio)morpholine
FR2618434B1 (fr) *	1987-07-21	1991-02-08	Oreal	Esters d'acide thiamorpholinone carboxylique et de ses derives, leur procede de preparation et leur utilisation dans le domaine cosmetique et dermo-pharmaceutique
AU4750990A (en) *	1988-12-14	1990-07-10	Hicks, Richard	Method for predicting biological activity of antibiotics, and novel non beta-lactam antibacterial agents derived therefrom
WO2013113860A1 (en)	2012-02-03	2013-08-08	Sanofi	Fused pyrroledicarboxamides and their use as pharmaceuticals

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2187327B1 (fi) *	1972-06-15	1975-06-20	Rech Pharm Scientifiques
US4179276A (en) *	1977-02-01	1979-12-18	E. I. Du Pont De Nemours And Company	Novel imidazothiazine-1,3 (2H)-diones
JPS5540658A (en) *	1978-09-19	1980-03-22	Tanabe Seiyaku Co Ltd	1,4-thiazan-3-carboxylic ester derivative and its preparation

1981
- 1981-04-29 LU LU83327A patent/LU83327A1/fr unknown
1982
- 1982-04-21 GB GB08235353A patent/GB2111056B/en not_active Expired
- 1982-04-21 JP JP57501451A patent/JPS58500713A/ja active Granted
- 1982-04-21 WO PCT/BE1982/000009 patent/WO1982003860A1/en active IP Right Grant
- 1982-04-21 NL NL8220153A patent/NL8220153A/nl unknown
- 1982-04-28 ES ES82511759A patent/ES511759A0/es active Granted
- 1982-04-28 PT PT74813A patent/PT74813B/pt unknown
- 1982-04-29 FR FR8207461A patent/FR2509303A1/fr not_active Withdrawn
- 1982-04-29 BE BE0/207967A patent/BE893025A/fr not_active IP Right Cessation
- 1982-04-29 GR GR68018A patent/GR75996B/el unknown
- 1982-04-29 KR KR1019820001874A patent/KR830010089A/ko unknown
- 1982-04-29 IT IT20998/82A patent/IT1190794B/it active
- 1982-04-29 ZA ZA822926A patent/ZA822926B/xx unknown
- 1982-12-14 FI FI771226A patent/FI66366C/fi not_active IP Right Cessation
- 1982-12-21 SE SE8207294A patent/SE8207294L/xx not_active Application Discontinuation
- 1982-12-28 NO NO824398A patent/NO824398L/no unknown

Also Published As

Publication number	Publication date
PT74813A (fr)	1982-05-01
GB2111056B (en)	1985-03-06
BE893025A (fr)	1982-10-29
JPH0330592B2 (fi)	1991-04-30
ES8307233A1 (es)	1983-07-01
LU83327A1 (fr)	1983-03-24
JPS58500713A (ja)	1983-05-06
PT74813B (fr)	1983-10-26
FI824279L (fi)	1982-12-14
KR830010089A (ko)	1983-12-26
ZA822926B (en)	1983-03-30
FR2509303A1 (fr)	1983-01-14
NL8220153A (nl)	1983-03-01
IT1190794B (it)	1988-02-24
GB2111056A (en)	1983-06-29
ES511759A0 (es)	1983-07-01
FI66366B (fi)	1984-06-29
WO1982003860A1 (en)	1982-11-11
SE8207294D0 (sv)	1982-12-21
SE8207294L (sv)	1982-12-21
FI824279A0 (fi)	1982-12-14
FI66366C (fi)	1984-10-10
IT8220998A0 (it)	1982-04-29
GR75996B (fi)	1984-08-03

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EP0305947A1 (en)	1989-03-08	Hydantoin derivatives, process for their preparation and pharmaceutical compositions containing the same as well as their use
NO824398L (no)	1982-12-28	1,4-tiazankarboksylsyrederivater, fremstilling og bruk av disse og blandinger hvori disse derivater er tilstede
PT93985B (pt)	1996-11-29	Processo e produtos intermedios para a preparacao de acidos aceticos oxoftalazinilicos e seus analogos
US3681360A (en)	1972-08-01	Antiviral substituted acridanones
NO764039L (fi)	1977-06-06
KR900003368B1 (ko)	1990-05-16	신규한 인데노티아졸 유도체의 제조방법
EP1416936B1 (en)	2005-06-01	Thiopyrane-4-ones as dna protein kinase inhibitors
AU624406B2 (en)	1992-06-11	2-aminobenzyl (thiosulfinyl) imidazole derivatives
US3719671A (en)	1973-03-06	10-imidoylphenothiazines
EP0274654A2 (de)	1988-07-20	1,2,3-Triazin-4(3H)-on-Derivate, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
US4748280A (en)	1988-05-31	Certain chlorination process for preparing 2-chloro-1,1,1-(C1 -C6)
CA1257589A (en)	1989-07-18	Derivatives of oxazinobenzothiazine-6,6-dioxide, the production thereof, and the use thereof as medicaments
US4742163A (en)	1988-05-03	Alpha-tocopherol (halo)uridine phosphoric acid diester, salts thereof, and methods for producing the same
US4090020A (en)	1978-05-16	Thienothiazine derivatives
JPS61205275A (ja)	1986-09-11	新規の８‐チオテトラヒドロキノリン誘導体及びそれらの塩
EP0009142A1 (de)	1980-04-02	Neue 4-Hydroxy-2H(1)benzothieno(2,3-e)-1,2-thiazin-3-carboxamid-1,1-dioxide sowie deren Salze, deren Verwendung und Verfahren zu ihrer Herstellung
NO164352B (no)	1990-06-18	Analogifremgangsmaate for fremstilling av farmasoeytisk aktive, antivirale, substituerte isoksazolderivater.
NO812527L (no)	1982-01-25	Fremgangsmaate for fremstilling av nye derivater av tiazolo-(3,2-a)pyrimidin.
US4175085A (en)	1979-11-20	Thienothiazine derivatives
GB1569238A (en)	1980-06-11	2,5-dihdro-1,2-thiazino(5,6-b)indol-3-carboxamide-1,1-dioxide derivatives