MX9701676A - Transferencia de moleculas al citosol de celulas. - Google Patents
Transferencia de moleculas al citosol de celulas.Info
- Publication number
- MX9701676A MX9701676A MX9701676A MX9701676A MX9701676A MX 9701676 A MX9701676 A MX 9701676A MX 9701676 A MX9701676 A MX 9701676A MX 9701676 A MX9701676 A MX 9701676A MX 9701676 A MX9701676 A MX 9701676A
- Authority
- MX
- Mexico
- Prior art keywords
- cells
- molecules
- cytosol
- transfer
- endosomes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Catalysts (AREA)
Abstract
Se describe un método para liberar moléculas hacia citosol de células sin aniquilar la mayor parte de las células permitiendo que las moléculas sean tomadas en endosomas, lisosomas u otros compartimientos de células, y la activacion de la luz de compuestos fotosesibilizadores para romper las membranas de los endosomas, lisosomas u otros compartimientos de células.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO943327A NO180167C (no) | 1994-09-08 | 1994-09-08 | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
PCT/NO1995/000149 WO1996007432A1 (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9701676A true MX9701676A (es) | 1998-04-30 |
Family
ID=19897382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9701676A MX9701676A (es) | 1994-09-08 | 1995-09-04 | Transferencia de moleculas al citosol de celulas. |
Country Status (20)
Country | Link |
---|---|
US (3) | US5876989A (es) |
EP (1) | EP0783323B1 (es) |
JP (1) | JP4148328B2 (es) |
KR (2) | KR100395615B1 (es) |
CN (1) | CN1222309C (es) |
AT (1) | ATE209507T1 (es) |
AU (1) | AU700797B2 (es) |
BR (1) | BRPI9508825B8 (es) |
CA (1) | CA2199290C (es) |
CZ (1) | CZ65897A3 (es) |
DE (1) | DE69524238T2 (es) |
ES (1) | ES2163527T3 (es) |
FI (1) | FI121328B (es) |
HK (1) | HK1004110A1 (es) |
HU (1) | HU222984B1 (es) |
MX (1) | MX9701676A (es) |
NO (1) | NO180167C (es) |
NZ (2) | NZ293008A (es) |
PT (1) | PT783323E (es) |
WO (1) | WO1996007432A1 (es) |
Families Citing this family (83)
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NO180167C (no) * | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
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ATE409005T1 (de) * | 1997-03-19 | 2008-10-15 | Lucid Inc | Zellchirurgie unter benutzung konfokaler mikroskopie |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
US6582392B1 (en) * | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
EP2138191A1 (en) * | 1998-01-05 | 2009-12-30 | University Of Washington | Enhanced transport using membrane disruptive agents |
US6399769B1 (en) * | 1998-01-20 | 2002-06-04 | Kimberly-Clark Worldwide, Inc. | Method of making sulfanatophenyl substituted porphines |
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AU6871800A (en) | 1999-09-09 | 2001-04-17 | Center For Advanced Science And Technology Incubation, Ltd. | Method of piercing membrane and apparatus therefor |
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ES2445579T3 (es) * | 2000-11-29 | 2014-03-04 | Pci Biotech As | Internalización fotoquímica para el suministro de moléculas mediado por virus en el citosol |
CZ301427B6 (cs) * | 2000-11-29 | 2010-02-24 | Pci Biotech As | Zpusob zavedení molekuly do cytosolu bunky |
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US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
US6921371B2 (en) * | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
JP2006517790A (ja) * | 2003-01-09 | 2006-08-03 | インヴィトロジェン コーポレーション | ポリペプチド−核酸複合体の細胞の送達および活性化 |
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ATE464913T1 (de) * | 2003-09-29 | 2010-05-15 | Nitto Denko Corp | Biologisch abbaubare polyacetale für die in-vivo- abgabe von polynucleotiden |
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US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
PL2170181T3 (pl) | 2007-06-22 | 2014-08-29 | Ekos Corp | Sposób i aparat do leczenia wylewów wewnątrzczaszkowych |
WO2009079415A1 (en) * | 2007-12-14 | 2009-06-25 | Ekos Corporation | Ultrasound pulse shaping |
GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
US8426214B2 (en) * | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
GB0914286D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
US20110117668A1 (en) * | 2009-11-09 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Self-powered smart diagnostic devices |
GB201208548D0 (en) * | 2012-05-15 | 2012-06-27 | Pci Biotech As | Compound and method |
CA2906279A1 (en) | 2013-03-15 | 2014-09-18 | Pci Biotech As | A method of generating antigen presenting cells using photochemical internalisation |
GB2517707B (en) | 2013-08-28 | 2020-09-02 | Pci Biotech As | A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen |
JP6684215B2 (ja) | 2013-08-28 | 2020-04-22 | ピーシーアイ バイオテック エイエス | 予防接種用化合物および免疫化用化合物、ならびに予防接種方法および免疫化方法 |
US10973896B2 (en) | 2014-04-11 | 2021-04-13 | Pci Biotech As | Treatment or prevention of melanoma using photochemical internalization of a melanoma antigen |
BR112017003486A2 (pt) | 2014-08-28 | 2018-01-16 | Pci Biotech As | métodos para expressar uma molécula antigênica ou uma parte da mesma e gerar uma resposta imune, composição farmacêutica, célula ou população de células, usos de uma população de células e molécula antigênica, molécula antigênica, agente fotossensibilizante e citocina, produto, e, kit |
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CN110711249B (zh) * | 2019-09-19 | 2020-10-27 | 北京化工大学 | 一种溶酶体膜包覆纳米颗粒的制备方法 |
US20210322471A1 (en) | 2020-03-27 | 2021-10-21 | Dcprime B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
EP4127139A1 (en) | 2020-03-27 | 2023-02-08 | Mendus B.V. | Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
CN114163508B (zh) * | 2020-09-11 | 2024-07-16 | 王月志 | 能破坏细胞的氨基酸序列及相关核苷酸序列和相关的应用 |
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KR20230157388A (ko) | 2021-03-12 | 2023-11-16 | 멘두스 비.브이. | 백신접종의 방법 및 cd47 차단의 용도 |
GB202115451D0 (en) | 2021-10-27 | 2021-12-08 | Pci Biotech As | Method |
WO2024068795A1 (en) | 2022-09-27 | 2024-04-04 | Pci Biotech As | Method for releasing viral vectors |
GB202301312D0 (en) | 2023-01-30 | 2023-03-15 | Pci Biotech As | Method and product |
GB202404168D0 (en) | 2024-03-22 | 2024-05-08 | Pci Biotech As | Method |
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-
1994
- 1994-09-08 NO NO943327A patent/NO180167C/no not_active IP Right Cessation
-
1995
- 1995-09-04 US US08/793,794 patent/US5876989A/en not_active Expired - Lifetime
- 1995-09-04 AT AT95932244T patent/ATE209507T1/de active
- 1995-09-04 MX MX9701676A patent/MX9701676A/es unknown
- 1995-09-04 AU AU35347/95A patent/AU700797B2/en not_active Expired
- 1995-09-04 HU HU9800153A patent/HU222984B1/hu active IP Right Grant
- 1995-09-04 WO PCT/NO1995/000149 patent/WO1996007432A1/en not_active Application Discontinuation
- 1995-09-04 NZ NZ293008A patent/NZ293008A/en not_active IP Right Cessation
- 1995-09-04 EP EP95932244A patent/EP0783323B1/en not_active Expired - Lifetime
- 1995-09-04 BR BRPI9508825A patent/BRPI9508825B8/pt not_active IP Right Cessation
- 1995-09-04 CZ CZ97658A patent/CZ65897A3/cs unknown
- 1995-09-04 CN CNB951960652A patent/CN1222309C/zh not_active Expired - Lifetime
- 1995-09-04 PT PT95932244T patent/PT783323E/pt unknown
- 1995-09-04 CA CA2199290A patent/CA2199290C/en not_active Expired - Lifetime
- 1995-09-04 JP JP50940496A patent/JP4148328B2/ja not_active Expired - Fee Related
- 1995-09-04 DE DE69524238T patent/DE69524238T2/de not_active Expired - Lifetime
- 1995-09-04 NZ NZ509519A patent/NZ509519A/en not_active IP Right Cessation
- 1995-09-04 ES ES95932244T patent/ES2163527T3/es not_active Expired - Lifetime
- 1995-09-14 KR KR1019970701520A patent/KR100395615B1/ko active IP Right Grant
- 1995-09-14 KR KR10-2003-7005142A patent/KR100529967B1/ko not_active IP Right Cessation
-
1997
- 1997-03-07 FI FI970983A patent/FI121328B/fi not_active IP Right Cessation
-
1998
- 1998-04-24 HK HK98103468A patent/HK1004110A1/xx not_active IP Right Cessation
- 1998-09-01 US US09/144,750 patent/US6680301B2/en not_active Expired - Fee Related
-
2002
- 2002-11-01 US US10/286,632 patent/US20030134813A1/en not_active Abandoned
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