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MX370659B - Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa). - Google Patents

Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa).

Info

Publication number
MX370659B
MX370659B MX2016012550A MX2016012550A MX370659B MX 370659 B MX370659 B MX 370659B MX 2016012550 A MX2016012550 A MX 2016012550A MX 2016012550 A MX2016012550 A MX 2016012550A MX 370659 B MX370659 B MX 370659B
Authority
MX
Mexico
Prior art keywords
conditions
lpa
autotaxin
atx
compounds
Prior art date
Application number
MX2016012550A
Other languages
English (en)
Other versions
MX2016012550A (es
Inventor
Rudolph Markus
Hunziker Daniel
Kuehne Holger
Hert Jérôme
Di Giorgio Patrick
Mattei Patrizio
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2016012550A publication Critical patent/MX2016012550A/es
Publication of MX370659B publication Critical patent/MX370659B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención proporciona nuevos compuestos que tienen la fórmula general (I) (ver Fórmula) en la que R1, R2, A, W, m, n, p y q tienen los significados aquí descritos, composiciones que incluyen los compuestos y métodos de uso de los compuestos.
MX2016012550A 2014-03-26 2015-03-23 Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa). MX370659B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14161760 2014-03-26
PCT/EP2015/056032 WO2015144605A1 (en) 2014-03-26 2015-03-23 Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors

Publications (2)

Publication Number Publication Date
MX2016012550A MX2016012550A (es) 2016-12-14
MX370659B true MX370659B (es) 2019-12-19

Family

ID=50389849

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016012550A MX370659B (es) 2014-03-26 2015-03-23 Compuestos bicíclicos como inhibidores de producción de autotaxina (atx) y ácido lisofosfatídico (lpa).

Country Status (29)

Country Link
US (4) US9802944B2 (es)
EP (2) EP3590939A1 (es)
JP (2) JP6553637B2 (es)
KR (1) KR20160128345A (es)
CN (2) CN106103446B (es)
AR (1) AR099824A1 (es)
AU (2) AU2015238537B2 (es)
CA (1) CA2937616A1 (es)
CL (1) CL2016002310A1 (es)
CR (1) CR20160419A (es)
DK (1) DK3122750T3 (es)
EA (1) EA037928B1 (es)
ES (1) ES2753549T3 (es)
HR (1) HRP20191936T1 (es)
HU (1) HUE046820T2 (es)
IL (1) IL246708B (es)
LT (1) LT3122750T (es)
MA (2) MA39792B1 (es)
MX (1) MX370659B (es)
PE (1) PE20161134A1 (es)
PH (2) PH12016501632B1 (es)
PL (1) PL3122750T3 (es)
PT (1) PT3122750T (es)
RS (1) RS59477B1 (es)
SG (1) SG11201607839UA (es)
SI (1) SI3122750T1 (es)
TW (1) TWI708774B (es)
UA (1) UA118582C2 (es)
WO (1) WO2015144605A1 (es)

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