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MX346001B - Polipeptidos de eritropoyetina animal modificados y sus usos. - Google Patents

Polipeptidos de eritropoyetina animal modificados y sus usos.

Info

Publication number
MX346001B
MX346001B MX2012009511A MX2012009511A MX346001B MX 346001 B MX346001 B MX 346001B MX 2012009511 A MX2012009511 A MX 2012009511A MX 2012009511 A MX2012009511 A MX 2012009511A MX 346001 B MX346001 B MX 346001B
Authority
MX
Mexico
Prior art keywords
modified animal
erythropoietin polypeptides
animal erythropoietin
polypeptides
modified
Prior art date
Application number
MX2012009511A
Other languages
English (en)
Inventor
Feng Tian
Stephanie Chu
Joseph Sheffer
Peter C Canning
Frank Song
Richard S Barnett
Marc Siladi
Kyle Atkinson
Darin Lee
Putnam Anna-Maria A Hays
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42060418&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX346001(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX346001B publication Critical patent/MX346001B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un polipéptido de eritropoyetina felina (fEPO) que comprende un aminoácido no codificado de manera natural sustituido en una posición correspondiente a la posición 1 de la SEQ ID NO: 2, en donde el aminoácido no codificado de manera natural es reactivo hacia un enlazador, un polímero, o una molécula biológicamente activa que de otra manera no es reactiva hacia ninguno de los 20 aminoácidos comunes en el polipéptido, y en donde el aminoácido no codificado de manera natural comprende un grupo carbonilo, un grupo amino-oxilo, un grupo hidracina, un grupo hidrazida, un grupo semicarbaniza, un grupo azida o un grupo alquino, pero en donde dicho aminoácido no codificado de manera natural no es una para-acetil-finilalanina, y en donde el aminoácido no codificado de manera natural se enlaza aun polímero soluble en agua que comprende una fracción de pli-(etilen)-glicol, y en donde dicho polímero soluble en agua tiene un peso molecular de entre 0.1 kDa y 100kDa; y usos de los mismos. .
MX2012009511A 2008-09-26 2009-09-25 Polipeptidos de eritropoyetina animal modificados y sus usos. MX346001B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10069208P 2008-09-26 2008-09-26
US10067908P 2008-09-26 2008-09-26
PCT/US2009/058482 WO2010036964A2 (en) 2008-09-26 2009-09-25 Modified animal erythropoietin polypeptides and their uses

Publications (1)

Publication Number Publication Date
MX346001B true MX346001B (es) 2017-03-01

Family

ID=42060418

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2011003272A MX2011003272A (es) 2008-09-26 2009-09-25 Polipeptidos de eritropoyetina animal modificados y sus usos.
MX2012009511A MX346001B (es) 2008-09-26 2009-09-25 Polipeptidos de eritropoyetina animal modificados y sus usos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2011003272A MX2011003272A (es) 2008-09-26 2009-09-25 Polipeptidos de eritropoyetina animal modificados y sus usos.

Country Status (23)

Country Link
US (4) US8278418B2 (es)
EP (2) EP3216800A1 (es)
JP (1) JP5694171B2 (es)
KR (1) KR101647164B1 (es)
CN (2) CN107022020A (es)
AU (1) AU2009296397B2 (es)
BR (2) BRPI0919403A2 (es)
CA (1) CA2737026C (es)
CL (1) CL2011000613A1 (es)
CO (1) CO6362016A2 (es)
DK (1) DK2342223T3 (es)
EA (1) EA019653B1 (es)
ES (1) ES2631915T3 (es)
HU (1) HUE035168T2 (es)
IL (1) IL211600A (es)
MX (2) MX2011003272A (es)
NZ (2) NZ601659A (es)
PE (1) PE20110832A1 (es)
PL (1) PL2342223T3 (es)
PT (1) PT2342223T (es)
UA (1) UA106731C2 (es)
WO (1) WO2010036964A2 (es)
ZA (1) ZA201102716B (es)

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ES2631915T3 (es) * 2008-09-26 2017-09-06 Ambrx, Inc. Polipéptidos modificados de eritropoyetina animal y sus usos
EP2837392A3 (en) * 2009-09-15 2015-05-13 Kaneka Corporation Modified erythropoietin to which water-soluble long-chain molecule is added
KR20120117728A (ko) * 2009-09-23 2012-10-24 바이오제너릭스 에이지 재조합 인간 에리트로포이에틴(ｅｐｏ)의 정제 방법, 이렇게 정제된 ｅｐｏ 및 이를 포함하는 약학적 조성물
PT3572091T (pt) 2010-08-17 2024-03-01 Ambrx Inc Polipéptidos de relaxina modificados e as suas utilizações
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
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SG10201702176XA (en) * 2012-06-07 2017-04-27 Ambrx Inc Prostate-specific membrane antigen antibody drug conjugates
MX366375B (es) 2013-01-30 2019-07-05 Avelas Biosciences Inc Moleculas de administracion selectiva y metodos de uso.
CN107074928B (zh) * 2014-09-18 2021-03-12 奥美药业有限公司 新型猫促红细胞生成素受体激动剂
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AU2016315699B2 (en) * 2015-08-31 2021-09-09 The Trustees Of The University Of Pennsylvania AAV-EPO for treating companion animals
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US20190352609A1 (en) * 2017-01-05 2019-11-21 Shenzhen Mindray Bio-Medical Electronics Co., Ltd. Method for preparing reticulocyte simulating particles and platelet simulating particles, and reference control
MX2019008449A (es) 2017-02-08 2019-09-09 Bristol Myers Squibb Co Polipetidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos.
IL270179B2 (en) 2017-04-25 2024-07-01 Temple Otorongo Llc A pharmaceutical preparation containing tryptophan and a phyllokinin derivative for the treatment of psychiatric and psychological disorders
EP3634988A4 (en) * 2017-06-06 2021-02-24 Kindred Biosciences, Inc. ERYTHROPOIETIN AND ANALOGUE FOR USE IN VETERINARY MEDICINE
CN113423721A (zh) * 2018-12-12 2021-09-21 金德雷德生物科学股份有限公司 兽用促红细胞生成素类似物
EP3946457A1 (en) * 2019-04-01 2022-02-09 Genentech, Inc. Compositions and methods for stabilizing protein-containing formulations
CN113728227A (zh) * 2019-04-17 2021-11-30 Dmc全球公司 识别多层制品中健全结合和薄弱结合之间结合边界的方法和系统
RU2770425C2 (ru) * 2020-06-15 2022-04-18 Федеральное государственное бюджетное учреждение "48 Центральный научно-исследовательский институт" Министерства обороны Российской Федерации Способ получения иммуноглобулина противооспенного из сыворотки крови лошадей
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WO2022159414A1 (en) 2021-01-22 2022-07-28 University Of Rochester Erythropoietin for gastroinfestinal dysfunction
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