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MX345873B - Derivados de arilalquilaminocarboxamida fluorados. - Google Patents

Derivados de arilalquilaminocarboxamida fluorados.

Info

Publication number
MX345873B
MX345873B MX2013013776A MX2013013776A MX345873B MX 345873 B MX345873 B MX 345873B MX 2013013776 A MX2013013776 A MX 2013013776A MX 2013013776 A MX2013013776 A MX 2013013776A MX 345873 B MX345873 B MX 345873B
Authority
MX
Mexico
Prior art keywords
fluorinated
derivatives
arylalkylaminocarboxamide derivatives
fluorinated arylalkylaminocarboxamide
urolological
Prior art date
Application number
MX2013013776A
Other languages
English (en)
Other versions
MX2013013776A (es
Inventor
Pevarello Paolo
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of MX2013013776A publication Critical patent/MX2013013776A/es
Publication of MX345873B publication Critical patent/MX345873B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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Abstract

La presente invención se refiere a derivados de arilalquilaminocarboxamida fluorados de la fórmula (I) en donde W, J, n, R1, R2, R2', R3, R4, R5 y R6 tienen los significados que se definieron en la especificación y a las sales de los mismos farmacéuticamente aceptables, a las composiciones farmacéuticas que los contienen como ingredientes activos y a su uso como moduladores de los canales de sodio y/o de calcio útiles en la prevención, el alivio y la cura de una amplia gama de patologías, incluyendo las enfermedades neurológicas, psiquiátricas, cardiovasculares, inflamatorias, oftálmicas, urológicas y gastrointestinales, en donde los mecanismos anteriores han sido descritos como unos que desempeñan un papel patológico.
MX2013013776A 2011-06-27 2012-05-29 Derivados de arilalquilaminocarboxamida fluorados. MX345873B (es)

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