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MX344166B - Leptina-polipeptidos modificados y sus usos. - Google Patents

Leptina-polipeptidos modificados y sus usos.

Info

Publication number
MX344166B
MX344166B MX2013007824A MX2013007824A MX344166B MX 344166 B MX344166 B MX 344166B MX 2013007824 A MX2013007824 A MX 2013007824A MX 2013007824 A MX2013007824 A MX 2013007824A MX 344166 B MX344166 B MX 344166B
Authority
MX
Mexico
Prior art keywords
leptin polypeptides
modified leptin
modified
polypeptides
modified human
Prior art date
Application number
MX2013007824A
Other languages
English (en)
Inventor
Nick Knudsen
Vadim Kraynov
Jason Pinkstaff
Heather Myler
Anna-Maria A Hays Putnam
Lorraine Sullivan
Original Assignee
Ambrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ambrx Inc filed Critical Ambrx Inc
Publication of MX344166B publication Critical patent/MX344166B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/5759Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Reproductive Health (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a un leptina-polipéptido que comprende uno o más aminoácidos no naturalmente codificados, sustituidos en las posiciones seleccionadas de 46, 66, 67, 100, 105, 108 y 111 de la SEQ ID NO: 4 o el aminoácido correspondiente codificado por la SEQ ID NO: 3 o las posiciones 45, 65, 66, 99, 104, 107 y 110 de la SEQ ID NO; 2, en donde un polímero soluble en agua se une a un aminoácido codificado no naturalmente, presente en dicho polipéptido de leptina.
MX2013007824A 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos. MX344166B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2741408P 2008-02-08 2008-02-08
PCT/US2009/033277 WO2009100255A2 (en) 2008-02-08 2009-02-05 Modified leptin polypeptides and their uses

Publications (1)

Publication Number Publication Date
MX344166B true MX344166B (es) 2016-12-07

Family

ID=40952687

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2010008632A MX2010008632A (es) 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos.
MX2013007824A MX344166B (es) 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2010008632A MX2010008632A (es) 2008-02-08 2009-02-05 Leptina-polipeptidos modificados y sus usos.

Country Status (11)

Country Link
US (1) US9938333B2 (es)
EP (2) EP2247743B1 (es)
JP (2) JP5702150B2 (es)
CN (2) CN101939443B (es)
AU (1) AU2009212311B8 (es)
CA (1) CA2712606A1 (es)
IL (1) IL207096A (es)
MX (2) MX2010008632A (es)
NZ (3) NZ586947A (es)
SG (1) SG188143A1 (es)
WO (1) WO2009100255A2 (es)

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RS59193B1 (sr) 2010-08-17 2019-10-31 Ambrx Inc Modifikovani polipeptidi relaksina i njihova primena
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
WO2012050930A2 (en) * 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc Engineered polypeptides having enhanced duration of action
EP2670704B1 (en) 2011-02-02 2018-12-12 Bio-Rad Laboratories, Inc. Apatite surface neutralization with alkali solutions
DK2729160T3 (da) * 2011-07-08 2019-07-01 Aegerion Pharmaceuticals Inc Manipulerede polypeptider, der har forbedret virkningstid og reduceret immunogenicitet
WO2013019681A2 (en) 2011-07-29 2013-02-07 Avelas Biosciences, Inc. Selective delivery molecules and methods of use
WO2013130913A1 (en) * 2012-02-29 2013-09-06 Ambrx, Inc. Interleukin-10 polypeptide conjugates and their uses
WO2013180933A1 (en) 2012-05-30 2013-12-05 Bio-Rad Laboratories, Inc. In situ restoration of apatite-based chromatography resins
KR102278630B1 (ko) 2013-01-30 2021-07-16 아벨라스 바이오사이언시즈 인코포레이티드 선택적 전달 분자 및 사용 방법
HUE033443T2 (en) * 2013-03-13 2017-11-28 Lilly Co Eli Modified rabbit leptin polypeptides
WO2015200278A1 (en) * 2014-06-23 2015-12-30 Bio-Rad Laboratories, Inc. Apatite in-situ restoration
EP3157689B1 (en) 2014-06-23 2021-04-28 Bio-Rad Laboratories, Inc. Apatite pretreatment
CN104829707B (zh) * 2015-05-06 2017-12-19 广东省生物资源应用研究所 一条cd环和e螺旋区突变的瘦素活性肽及其编码基因和应用
CN104829705B (zh) * 2015-05-06 2017-11-14 广东省生物资源应用研究所 一条c螺旋区突变的瘦素活性肽及其编码基因和应用
CN104829708B (zh) * 2015-05-06 2017-11-28 广东省生物资源应用研究所 一条d螺旋区突变的瘦素活性肽及其编码基因和应用
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
TW201837051A (zh) 2017-02-08 2018-10-16 美商必治妥美雅史谷比公司 包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途
EP3994168A4 (en) * 2019-07-02 2023-04-05 Shanghaitech University ANTIBODIES AGAINST LEPTIN RECEPTOR
US20210324031A1 (en) * 2019-10-16 2021-10-21 Clarence Hurt Compounds, compositions, methods, and uses for treating leptin resistance, obesity, diabetes mellitus and metabolic syndrome

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EP2247743A2 (en) 2010-11-10
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AU2009212311B2 (en) 2013-01-31
US20120149636A1 (en) 2012-06-14
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CA2712606A1 (en) 2009-08-13
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