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MX2013004061A - Analogos de ciclosporina. - Google Patents

Analogos de ciclosporina.

Info

Publication number
MX2013004061A
MX2013004061A MX2013004061A MX2013004061A MX2013004061A MX 2013004061 A MX2013004061 A MX 2013004061A MX 2013004061 A MX2013004061 A MX 2013004061A MX 2013004061 A MX2013004061 A MX 2013004061A MX 2013004061 A MX2013004061 A MX 2013004061A
Authority
MX
Mexico
Prior art keywords
cyclosporin analogs
cyclosporin
analogs
treatment
disclosed
Prior art date
Application number
MX2013004061A
Other languages
English (en)
Inventor
William Robert Carling
Michael E Garst
Catherine Simone Victorire Frydrych
Michael E Stern
Christopher S Schaumburg
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of MX2013004061A publication Critical patent/MX2013004061A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se describen en la presente nuevos análogos de ciclosporina, composiciones farmacéuticas que los contienen, y métodos para su uso en el tratamiento del ojo seco y otras afecciones.
MX2013004061A 2010-10-12 2011-10-11 Analogos de ciclosporina. MX2013004061A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39244910P 2010-10-12 2010-10-12
PCT/US2011/055791 WO2012051194A1 (en) 2010-10-12 2011-10-11 Cyclosporin analogs

Publications (1)

Publication Number Publication Date
MX2013004061A true MX2013004061A (es) 2013-07-22

Family

ID=44883784

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013004061A MX2013004061A (es) 2010-10-12 2011-10-11 Analogos de ciclosporina.

Country Status (13)

Country Link
US (3) US20120088734A1 (es)
EP (1) EP2627664B1 (es)
JP (2) JP5805774B2 (es)
KR (1) KR20140026329A (es)
CN (1) CN103328497A (es)
AU (1) AU2011316690C1 (es)
BR (1) BR112013008864A2 (es)
CA (1) CA2814192A1 (es)
IL (1) IL225617A0 (es)
MX (1) MX2013004061A (es)
RU (1) RU2013119869A (es)
SG (1) SG189880A1 (es)
WO (1) WO2012051194A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103153330B (zh) 2010-08-12 2017-08-18 美国科技环球有限公司 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用
JP5805774B2 (ja) * 2010-10-12 2015-11-10 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ
BR112013008749A2 (pt) 2010-10-12 2019-09-24 Allergan Inc análogos de ciclosporina
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
RU2630690C9 (ru) * 2010-12-15 2017-12-28 КонтраВир Фармасьютикалз, Инк. МОЛЕКУЛЫ АНАЛОГОВ ЦИКЛОСПОРИНА, МОДИФИЦИРОВАННЫЕ ПО 1 и 3 АМИНОКИСЛОТЕ
CN104487449A (zh) 2012-06-01 2015-04-01 阿勒根公司 环孢菌素a类似物
GB201222455D0 (en) * 2012-12-13 2013-01-30 Perioc Ltd Novel pharmaceutical formulations and their use in the treatment of periodontaldisease
US20140256696A1 (en) 2013-03-08 2014-09-11 Allergan, Inc. Steroid conjugates
WO2016112321A1 (en) 2015-01-08 2016-07-14 Allergan, Inc. Cyclosporin derivatives wherein the mebmt sidechain has been cyclized
US10077289B2 (en) 2015-03-31 2018-09-18 Allergan, Inc. Cyclosporins modified on the MeBmt sidechain by heterocyclic rings
US20190151403A1 (en) * 2016-05-17 2019-05-23 S&T Global Inc. Novel cyclosporin derivatives and uses thereof
WO2018106931A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554346B1 (en) 2016-12-14 2024-01-31 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
US20230041197A1 (en) 2018-06-20 2023-02-09 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an immunomodulator
WO2021173474A1 (en) * 2020-02-26 2021-09-02 Bacainn Biotherapeutics, Ltd. Cyclosporine compositions and methods of use
CN113173974B (zh) * 2021-03-18 2024-09-06 北京大学深圳研究生院 环孢素衍生物的合成方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4649047A (en) * 1985-03-19 1987-03-10 University Of Georgia Research Foundation, Inc. Ophthalmic treatment by topical administration of cyclosporin
US4839342A (en) 1987-09-03 1989-06-13 University Of Georgia Research Foundation, Inc. Method of increasing tear production by topical administration of cyclosporin
US5474979A (en) 1994-05-17 1995-12-12 Allergan, Inc. Nonirritating emulsions for sensitive tissue
FR2757522B1 (fr) 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2757521B1 (fr) * 1996-12-24 1999-01-29 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2762843B1 (fr) * 1997-04-30 1999-12-10 Rhone Poulenc Rorer Sa Nouveaux derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
EP1086124B1 (en) * 1998-06-12 2003-11-19 C-Chem AG Novel cyclosporins
US6254860B1 (en) * 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US7676680B2 (en) 2005-07-08 2010-03-09 Morgan Stanley Systems and methods for distributing private placement documents
US7288520B2 (en) 2005-07-13 2007-10-30 Allergan, Inc. Cyclosporin compositions
DK2023918T3 (da) 2006-05-19 2011-04-26 Scynexis Inc Cyclosporiner til behandlingen og forebyggelse af okulære lidelser
CN101130058B (zh) * 2006-08-23 2011-10-05 华北制药集团新药研究开发有限责任公司 一种环孢菌素a眼用乳剂及其制备方法
BRPI0811538A2 (pt) * 2007-05-04 2015-08-11 Allergan Inc Uso de ciclosporinas no tratamento de pacientes com lentes intraoculares.
KR20110031973A (ko) * 2008-07-10 2011-03-29 알러간, 인코포레이티드 눈 및 피부의 질환 및 상태를 치료하기 위한 사이클로스포린 유도체
MY164051A (en) * 2010-07-02 2017-11-15 Exxonmobil Upstream Res Co Low emission triple-cycle power generation systems and methods
WO2012005494A2 (ko) 2010-07-06 2012-01-12 엘지전자 주식회사 무선 통신 시스템에서 머신형 통신 장치를 위한 무선 자원 할당 방법 및 장치
JP5805774B2 (ja) * 2010-10-12 2015-11-10 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンアナログ
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
WO2012075494A1 (en) * 2010-12-03 2012-06-07 S&T Global Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
WO2013028615A2 (en) * 2011-08-19 2013-02-28 S&T Golbal Inc. Novel cyclosporin derivatives for the treatment and prevention of viral infections

Also Published As

Publication number Publication date
EP2627664A1 (en) 2013-08-21
CN103328497A (zh) 2013-09-25
JP6250608B2 (ja) 2017-12-20
JP5805774B2 (ja) 2015-11-10
US10065992B2 (en) 2018-09-04
US20150065433A1 (en) 2015-03-05
JP2013540776A (ja) 2013-11-07
BR112013008864A2 (pt) 2016-06-28
AU2011316690C1 (en) 2017-01-19
KR20140026329A (ko) 2014-03-05
JP2016029050A (ja) 2016-03-03
IL225617A0 (en) 2013-06-27
US9493511B2 (en) 2016-11-15
AU2011316690B2 (en) 2016-07-07
EP2627664B1 (en) 2018-04-04
WO2012051194A1 (en) 2012-04-19
AU2011316690A1 (en) 2013-05-02
US20170029469A1 (en) 2017-02-02
US20120088734A1 (en) 2012-04-12
CA2814192A1 (en) 2012-04-19
RU2013119869A (ru) 2014-11-20
SG189880A1 (en) 2013-06-28

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