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MX2008012023A - Metodos para prevenir y tratar enfermedades amiloidogenicas. - Google Patents

Metodos para prevenir y tratar enfermedades amiloidogenicas.

Info

Publication number
MX2008012023A
MX2008012023A MX2008012023A MX2008012023A MX2008012023A MX 2008012023 A MX2008012023 A MX 2008012023A MX 2008012023 A MX2008012023 A MX 2008012023A MX 2008012023 A MX2008012023 A MX 2008012023A MX 2008012023 A MX2008012023 A MX 2008012023A
Authority
MX
Mexico
Prior art keywords
preventing
methods
amyloidogenic diseases
treating
treating amyloidogenic
Prior art date
Application number
MX2008012023A
Other languages
English (en)
Inventor
Xiang-Yang Tan
Lioudmila Tchistiakova
Jack Steven Jacobsen
Angela Widom
Sreekumar Raman Kodangattil
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of MX2008012023A publication Critical patent/MX2008012023A/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/46—Hybrid immunoglobulins
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)

Abstract

Un método para tratar una enfermedad o trastorno caracterizado por depósitos amiloides de A( que comprende administrar al sujeto una cantidad terapéuticamente efectiva de un anticuerpo que se une específicamente al RAGE e inhibe la unión de un compañero de unión RAGE.
MX2008012023A 2006-03-21 2007-03-21 Metodos para prevenir y tratar enfermedades amiloidogenicas. MX2008012023A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78457506P 2006-03-21 2006-03-21
US89530307P 2007-03-16 2007-03-16
PCT/US2007/064571 WO2007109749A2 (en) 2006-03-21 2007-03-21 Methods for preventing and treating amyloidogenic diseases

Publications (1)

Publication Number Publication Date
MX2008012023A true MX2008012023A (es) 2008-10-01

Family

ID=38523302

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2008011933A MX2008011933A (es) 2006-03-21 2007-03-21 Metodos y composiciones para antagonismo de rage.
MX2008012023A MX2008012023A (es) 2006-03-21 2007-03-21 Metodos para prevenir y tratar enfermedades amiloidogenicas.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2008011933A MX2008011933A (es) 2006-03-21 2007-03-21 Metodos y composiciones para antagonismo de rage.

Country Status (13)

Country Link
US (2) US20070253950A1 (es)
EP (2) EP2004694A2 (es)
JP (2) JP2009530423A (es)
KR (2) KR20080110833A (es)
AU (2) AU2007226861A1 (es)
BR (2) BRPI0708970A2 (es)
CA (2) CA2646643A1 (es)
CR (2) CR10298A (es)
EC (1) ECSP088750A (es)
MX (2) MX2008011933A (es)
NO (2) NO20083720L (es)
RU (2) RU2008137764A (es)
WO (2) WO2007109749A2 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020019095A1 (es) * 2018-07-26 2020-01-30 Universidad Católica Del Maule Proteína rage (receptor de productos finales de glicacíon avanzada) como biomarcador de sensibilidad tumoral y evaluacion de terapia radiologica y radiomimética

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