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MEP10709A - 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF - Google Patents

2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

Info

Publication number
MEP10709A
MEP10709A MEP-107/09A MEP10709A MEP10709A ME P10709 A MEP10709 A ME P10709A ME P10709 A MEP10709 A ME P10709A ME P10709 A MEP10709 A ME P10709A
Authority
ME
Montenegro
Prior art keywords
group
aryl
cycloalkyl
phenylimidazo
alpha
Prior art date
Application number
MEP-107/09A
Other languages
Bosnian (bs)
English (en)
Inventor
Garcia Antonio Almario
Patrick Lardenois
Anne Olivier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ME00615B publication Critical patent/ME00615B/fr
Publication of MEP10709A publication Critical patent/MEP10709A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Addiction (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MEP-107/09A 2006-09-22 2007-09-19 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF MEP10709A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (fr) 2006-09-22 2006-09-22 Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
PCT/FR2007/001517 WO2008034974A1 (fr) 2006-09-22 2007-09-19 DERIVES DE 2-ARYL-6-PHENYL-IMIDAZO[1,2-α]PYRIDINES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (2)

Publication Number Publication Date
ME00615B ME00615B (fr) 2011-12-20
MEP10709A true MEP10709A (en) 2011-12-20

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-107/09A MEP10709A (en) 2006-09-22 2007-09-19 2-ARYL-6-PHENYLIMIDAZO[1,2-alpha]PYRIDINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

Country Status (44)

Country Link
US (1) US7915284B2 (fr)
EP (1) EP2069342B1 (fr)
JP (1) JP5336378B2 (fr)
KR (1) KR101470039B1 (fr)
CN (1) CN101516881B (fr)
AR (1) AR062897A1 (fr)
AT (1) ATE467633T1 (fr)
AU (1) AU2007298856B2 (fr)
BR (1) BRPI0718517A2 (fr)
CA (1) CA2662848C (fr)
CL (1) CL2007002733A1 (fr)
CO (1) CO6160308A2 (fr)
CR (1) CR10643A (fr)
CY (1) CY1110232T1 (fr)
DE (1) DE602007006525D1 (fr)
DK (1) DK2069342T3 (fr)
EA (1) EA017442B1 (fr)
ES (1) ES2345016T3 (fr)
FR (1) FR2906250B1 (fr)
GT (1) GT200900049A (fr)
HK (1) HK1135388A1 (fr)
HN (1) HN2009000502A (fr)
HR (1) HRP20100408T1 (fr)
IL (1) IL197352A (fr)
JO (1) JO2643B1 (fr)
MA (1) MA30792B1 (fr)
ME (1) MEP10709A (fr)
MX (1) MX2009002802A (fr)
MY (1) MY145603A (fr)
NI (1) NI200900037A (fr)
NO (1) NO20091562L (fr)
NZ (1) NZ575337A (fr)
PE (1) PE20080671A1 (fr)
PL (1) PL2069342T3 (fr)
PT (1) PT2069342E (fr)
RS (1) RS51412B (fr)
SI (1) SI2069342T1 (fr)
SV (1) SV2009003193A (fr)
TN (1) TN2009000081A1 (fr)
TW (1) TWI381837B (fr)
UA (1) UA95976C2 (fr)
UY (1) UY30603A1 (fr)
WO (1) WO2008034974A1 (fr)
ZA (1) ZA200901551B (fr)

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FR2928921B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928924B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2933609B1 (fr) * 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
JP6007339B2 (ja) * 2012-11-29 2016-10-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ イミダゾピリジン誘導体
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
ES2716762T3 (es) 2013-02-04 2019-06-14 Janssen Pharmaceutica Nv Moduladores de FLAP
CN109575018A (zh) * 2013-08-02 2019-04-05 韩国巴斯德研究所 一种抗感染化合物
CN110872289A (zh) 2015-04-10 2020-03-10 百济神州(北京)生物科技有限公司 作为IDO1和/或TDO抑制剂的新颖的8-取代的咪唑并[1,5-a]吡啶
MA52119A (fr) 2015-10-19 2018-08-29 Ncyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
AU2016358100B2 (en) 2015-11-19 2021-05-27 Incyte Corporation Heterocyclic compounds as immunomodulators
BR112018012756A2 (pt) 2015-12-22 2018-12-04 Incyte Corp compostos heterocíclicos como imunomoduladores
TW201808950A (zh) 2016-05-06 2018-03-16 英塞特公司 作為免疫調節劑之雜環化合物
US20170342060A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
HRP20221030T1 (hr) 2016-06-20 2022-11-11 Incyte Corporation Heterociklički spojevi kao imunomodulatori
MA45669A (fr) 2016-07-14 2019-05-22 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
WO2018044783A1 (fr) 2016-08-29 2018-03-08 Incyte Corporation Composés hétérocycliques utilisés comme immunomodulateurs
EP3515914A4 (fr) * 2016-09-24 2020-04-15 BeiGene, Ltd. Nouvelles imidazo[1,5-a]pyridines substituées en position 5 ou 8 en tant qu'indoleamine et/ou tryptophane 2,3-dioxygénases
MX2019007651A (es) 2016-12-22 2020-02-07 Incyte Corp Derivados de tetrahidro imidazo[4,5-c]piridina como inductores de internalizacion de ligando 1 de muerte programada (pd-l1).
EP3558989B1 (fr) 2016-12-22 2021-04-14 Incyte Corporation Dérivés de triazolo[1,5-a]pyridine en tant qu'immunomodulateurs
MA47120A (fr) 2016-12-22 2021-04-28 Incyte Corp Dérivés pyridine utilisés en tant qu'immunomodulateurs
CN110582493B (zh) 2016-12-22 2024-03-08 因赛特公司 作为免疫调节剂的苯并噁唑衍生物
WO2019101188A1 (fr) 2017-11-25 2019-05-31 Beigene, Ltd. Nouveaux benzoimidazoles en tant qu'inhibiteurs sélectifs de l'indoléamine 2, 3-dioxygénases
DK3774791T3 (da) 2018-03-30 2023-01-23 Incyte Corp Heterocykliske forbindelser som immunmodulatorer
BR112020022936A2 (pt) 2018-05-11 2021-02-02 Incyte Corporation derivados de tetra-hidro-imidazo[4,5-c]piridina como imunomoduladores de pd-l1
US11753406B2 (en) 2019-08-09 2023-09-12 Incyte Corporation Salts of a PD-1/PD-L1 inhibitor
PE20221038A1 (es) 2019-09-30 2022-06-17 Incyte Corp Compuestos de pirido[3,2-d] pirimidina como inmunomoduladores
IL292524A (en) 2019-11-11 2022-06-01 Incyte Corp Salts and crystalline forms of pd-1/pd-l1 inhibitor
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
TW202233615A (zh) 2020-11-06 2022-09-01 美商英塞特公司 Ｐｄ—１／ｐｄ—ｌ１抑制劑之結晶形式
CR20230230A (es) 2020-11-06 2023-07-27 Incyte Corp Proceso para hacer un inhibidor de pd-1/pdl1 y sales y formas cristalinas del mismo

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JP4041624B2 (ja) * 1999-07-21 2008-01-30 三井化学株式会社 有機電界発光素子
AU2001249672A1 (en) * 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2- or 3-aryl substituted imidazo(1,2-a) pyridines as h3 antagonists
GB0119911D0 (en) * 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
NZ538566A (en) * 2002-09-19 2008-02-29 Schering Corp Imidazopyridines as cyclin dependent kinase inhibitors
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
CA2554554A1 (fr) * 2004-03-08 2005-09-22 The University Of North Carolina At Chapel Hill Nouvelles c imidazo[1,2-a]pyridines dicationique et nouvelles 5,6,7,8-tetrahydro-imidazo[1,2a]pyridines utilisee s comme agents antiprotozoaires

Also Published As

Publication number Publication date
CA2662848A1 (fr) 2008-03-27
MX2009002802A (es) 2009-04-01
ME00615B (fr) 2011-12-20
ZA200901551B (en) 2010-06-30
DK2069342T3 (da) 2010-08-23
IL197352A0 (en) 2009-12-24
CN101516881A (zh) 2009-08-26
MY145603A (en) 2012-03-15
US20090253735A1 (en) 2009-10-08
EP2069342B1 (fr) 2010-05-12
AU2007298856A1 (en) 2008-03-27
TWI381837B (zh) 2013-01-11
CA2662848C (fr) 2014-12-23
CO6160308A2 (es) 2010-05-20
FR2906250B1 (fr) 2008-10-31
NI200900037A (es) 2014-02-20
CY1110232T1 (el) 2015-01-14
JP2010504309A (ja) 2010-02-12
AR062897A1 (es) 2008-12-10
KR101470039B1 (ko) 2014-12-05
IL197352A (en) 2014-11-30
TN2009000081A1 (en) 2010-08-19
UA95976C2 (en) 2011-09-26
RS51412B (en) 2011-02-28
WO2008034974A1 (fr) 2008-03-27
EP2069342A1 (fr) 2009-06-17
PE20080671A1 (es) 2008-07-14
US7915284B2 (en) 2011-03-29
NO20091562L (no) 2009-04-20
SI2069342T1 (sl) 2010-09-30
TW200833329A (en) 2008-08-16
EA017442B1 (ru) 2012-12-28
HK1135388A1 (fr) 2010-06-04
JO2643B1 (en) 2012-06-17
MA30792B1 (fr) 2009-10-01
UY30603A1 (es) 2008-05-02
AU2007298856B2 (en) 2012-08-09
CL2007002733A1 (es) 2008-04-11
FR2906250A1 (fr) 2008-03-28
PT2069342E (pt) 2010-07-19
SV2009003193A (es) 2010-02-01
GT200900049A (es) 2010-03-04
HN2009000502A (es) 2011-07-11
BRPI0718517A2 (pt) 2013-11-19
PL2069342T3 (pl) 2010-10-29
ES2345016T3 (es) 2010-09-13
EA200970311A1 (ru) 2009-08-28
HRP20100408T1 (hr) 2010-09-30
DE602007006525D1 (de) 2010-06-24
CR10643A (es) 2009-04-29
NZ575337A (en) 2011-12-22
JP5336378B2 (ja) 2013-11-06
CN101516881B (zh) 2012-07-18
ATE467633T1 (de) 2010-05-15
KR20090054449A (ko) 2009-05-29

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