Nothing Special   »   [go: up one dir, main page]

CY1110232T1 - Παραγωγα 2-αρυλ-6-φαινυλ-ιμιδαζο[1,2-α]πυριδιν, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη αγωγη - Google Patents

Παραγωγα 2-αρυλ-6-φαινυλ-ιμιδαζο[1,2-α]πυριδιν, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη αγωγη

Info

Publication number
CY1110232T1
CY1110232T1 CY20101100678T CY101100678T CY1110232T1 CY 1110232 T1 CY1110232 T1 CY 1110232T1 CY 20101100678 T CY20101100678 T CY 20101100678T CY 101100678 T CY101100678 T CY 101100678T CY 1110232 T1 CY1110232 T1 CY 1110232T1
Authority
CY
Cyprus
Prior art keywords
optionally substituted
aryl
phenyl
cycloalkyl
imidazo
Prior art date
Application number
CY20101100678T
Other languages
English (en)
Inventor
Garcia Antonio Almario
Patrick Lardenois
Anne Olivier
Original Assignee
Sanofi-Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1110232T1 publication Critical patent/CY1110232T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η εφεύρεση αφορά σε παράγωγα του γενικού χημικού τύπου (I) στον οποίο : το R1 αντιπροσωπεύει μια ομάδα φαινυλ ή μια ομάδα ναφθυλ, όπου οι δυο ομάδες μπορούν ενδεχομένως να υποκατασταθούν. τα R2 και R3 αντιπροσωπεύουν, ανεξάρτητα το ένα από το άλλο, ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλ, (C3-C7)κυκλοαλκυλ, (C3-C7)κυκλοαλκυλ(C1-C3)αλκυλεν, ενδεχομένως υποκατεστημένη ∙ μια ομάδα αρυλ ενδεχομένως υποκατεστημένη . το R4 αντιπροσωπεύει ένα άτομο υδρογόνου, μια ομάδα (C1-C6)αλκυλ, (C3-C7)κυκλοαλκυλ, (C3-C7)κυκλοαλκυλ(C1-C3)αλκυλεν, ενδεχομένως υποκατεστημένη ∙ μια ομάδα αρυλ ενδεχομένως υποκατεστημένη από έναν ή περισσότερους υποκατάστατες σε κατάσταση βάσης ή άλατος προσθήκης σε ένα οξύ.
CY20101100678T 2006-09-22 2010-07-20 Παραγωγα 2-αρυλ-6-φαινυλ-ιμιδαζο[1,2-α]πυριδιν, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη αγωγη CY1110232T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0608350A FR2906250B1 (fr) 2006-09-22 2006-09-22 Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
EP07848251A EP2069342B1 (fr) 2006-09-22 2007-09-19 Derives de 2-aryl-6-phenyl-imidazo[1,2-a]pyridines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CY1110232T1 true CY1110232T1 (el) 2015-01-14

Family

ID=37841968

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100678T CY1110232T1 (el) 2006-09-22 2010-07-20 Παραγωγα 2-αρυλ-6-φαινυλ-ιμιδαζο[1,2-α]πυριδιν, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη αγωγη

Country Status (44)

Country Link
US (1) US7915284B2 (el)
EP (1) EP2069342B1 (el)
JP (1) JP5336378B2 (el)
KR (1) KR101470039B1 (el)
CN (1) CN101516881B (el)
AR (1) AR062897A1 (el)
AT (1) ATE467633T1 (el)
AU (1) AU2007298856B2 (el)
BR (1) BRPI0718517A2 (el)
CA (1) CA2662848C (el)
CL (1) CL2007002733A1 (el)
CO (1) CO6160308A2 (el)
CR (1) CR10643A (el)
CY (1) CY1110232T1 (el)
DE (1) DE602007006525D1 (el)
DK (1) DK2069342T3 (el)
EA (1) EA017442B1 (el)
ES (1) ES2345016T3 (el)
FR (1) FR2906250B1 (el)
GT (1) GT200900049A (el)
HK (1) HK1135388A1 (el)
HN (1) HN2009000502A (el)
HR (1) HRP20100408T1 (el)
IL (1) IL197352A (el)
JO (1) JO2643B1 (el)
MA (1) MA30792B1 (el)
ME (1) MEP10709A (el)
MX (1) MX2009002802A (el)
MY (1) MY145603A (el)
NI (1) NI200900037A (el)
NO (1) NO20091562L (el)
NZ (1) NZ575337A (el)
PE (1) PE20080671A1 (el)
PL (1) PL2069342T3 (el)
PT (1) PT2069342E (el)
RS (1) RS51412B (el)
SI (1) SI2069342T1 (el)
SV (1) SV2009003193A (el)
TN (1) TN2009000081A1 (el)
TW (1) TWI381837B (el)
UA (1) UA95976C2 (el)
UY (1) UY30603A1 (el)
WO (1) WO2008034974A1 (el)
ZA (1) ZA200901551B (el)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2928923B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-heteroaryl-6-phenyl-imidazo °1,2-a!pyridines, leur preparation et leur application en therapeutiques
FR2928921B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines, leur preparation et leur application en therapeutique
FR2928924B1 (fr) 2008-03-21 2010-04-23 Sanofi Aventis Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique
FR2928922B1 (fr) * 2008-03-21 2010-04-23 Sanofi Aventis Derives de 2-aryl-6-phenyl-imidazo°1,2-a!pyridines polysubstitues, leur preparation et leur application en therapeutique
FR2933609B1 (fr) * 2008-07-10 2010-08-27 Fournier Lab Sa Utilisation de derives d'indole comme activateurs de nurr-1, pour le traitement de la maladie de parkinson.
FR2950345B1 (fr) * 2009-09-18 2011-09-23 Sanofi Aventis Derives acetyleniques de 5-phenyl-pyrazolopyridine, leur preparation et leur application en therapeutique
FR2950344B1 (fr) * 2009-09-18 2011-11-25 Sanofi Aventis Derives de 5-phenyl-pyrazolopyridine, leur preparation et leur aplication en therapeutique.
FR2953520B1 (fr) * 2009-12-04 2011-11-25 Sanofi Aventis Derives de diphenyl-pyrazolopyridines, leur preparation et leur application en therapeutique
WO2014082979A1 (en) * 2012-11-29 2014-06-05 F. Hoffmann-La Roche Ag Imidazopyridine derivatives
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
EP2951170B1 (en) 2013-02-04 2018-10-24 Janssen Pharmaceutica NV Flap modulators
DK3027615T3 (da) * 2013-08-02 2021-10-25 Pasteur Institut Korea Antiinfektionsforbindelser
EP3280715B1 (en) 2015-04-10 2020-11-25 Beigene, Ltd. NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES
EP3365340B1 (en) 2015-10-19 2022-08-10 Incyte Corporation Heterocyclic compounds as immunomodulators
HRP20221035T1 (hr) 2015-11-19 2022-11-11 Incyte Corporation Heterociklički spojevi kao imunomodulatori
AU2016379372A1 (en) 2015-12-22 2018-08-02 Incyte Corporation Heterocyclic compounds as immunomodulators
WO2017192961A1 (en) 2016-05-06 2017-11-09 Incyte Corporation Heterocyclic compounds as immunomodulators
EP3464279B1 (en) 2016-05-26 2021-11-24 Incyte Corporation Heterocyclic compounds as immunomodulators
JP7000357B2 (ja) 2016-06-20 2022-01-19 インサイト・コーポレイション 免疫調節剤としての複素環化合物
MA45669A (fr) 2016-07-14 2019-05-22 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
MA46045A (fr) 2016-08-29 2021-04-28 Incyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
CN109952300B (zh) * 2016-09-24 2022-01-18 百济神州有限公司 5或8-取代的咪唑并[1,5-a]吡啶
WO2018119236A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
WO2018119266A1 (en) 2016-12-22 2018-06-28 Incyte Corporation Benzooxazole derivatives as immunomodulators
MA47120A (fr) 2016-12-22 2021-04-28 Incyte Corp Dérivés pyridine utilisés en tant qu'immunomodulateurs
DK3558990T3 (da) 2016-12-22 2022-09-12 Incyte Corp Tetrahydroimidazo[4,5-c]pyridinderivater som pd-l1 internaliseringsinducere
WO2019101188A1 (en) 2017-11-25 2019-05-31 Beigene, Ltd. Novel benzoimidazoles as selective inhibitors of indoleamine 2, 3-dioxygenases
EP3774791B1 (en) 2018-03-30 2022-12-21 Incyte Corporation Heterocyclic compounds as immunomodulators
CA3099994A1 (en) 2018-05-11 2019-11-04 Incyte Corporation Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators
JP2022544189A (ja) 2019-08-09 2022-10-17 インサイト・コーポレイション Ｐｄ－１／ｐｄ－ｌ１阻害剤の塩
CA3155852A1 (en) 2019-09-30 2021-04-08 Incyte Corporation PYRIDO[3,2-D]PYRIMIDINE COMPOUNDS AS IMMUNOMODULATORS
CA3160131A1 (en) 2019-11-11 2021-05-20 Incyte Corporation Salts and crystalline forms of a pd-1/pd-l1 inhibitor
US11780836B2 (en) 2020-11-06 2023-10-10 Incyte Corporation Process of preparing a PD-1/PD-L1 inhibitor
KR20230117573A (ko) 2020-11-06 2023-08-08 인사이트 코포레이션 Pd-1 및 pd-l1 억제제, 및 이의 염 및 결정형의 제조 방법
US11760756B2 (en) 2020-11-06 2023-09-19 Incyte Corporation Crystalline form of a PD-1/PD-L1 inhibitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4041624B2 (ja) * 1999-07-21 2008-01-30 三井化学株式会社 有機電界発光素子
US6489337B1 (en) * 2000-03-31 2002-12-03 Ortho-Mcneil Pharmaceutical, Inc. Method for treating histamine H3 receptor-mediated disorders with 2- or 3-aryl substituted imidazo[1,2-a] pyridines
GB0119911D0 (en) * 2001-08-15 2001-10-10 Novartis Ag Organic Compounds
MXPA05003058A (es) * 2002-09-19 2005-05-27 Schering Corp Nuevas imidazopiridinas como inhibidores de cinasa dependientes de ciclina.
GB0303503D0 (en) * 2003-02-14 2003-03-19 Novartis Ag Organic compounds
EP1745045A4 (en) * 2004-03-08 2009-07-22 Univ North Carolina NEW DIKATIONIC IMIDAZO [1,2-A] PYRIDINES AND 5,6,7,8-TETRAHYDROIMIDAZO [1,2-A] PYRIDINES AS AGENTS AGAINST PROTOZOES

Also Published As

Publication number Publication date
CA2662848C (fr) 2014-12-23
FR2906250A1 (fr) 2008-03-28
ME00615B (me) 2011-12-20
PE20080671A1 (es) 2008-07-14
DK2069342T3 (da) 2010-08-23
BRPI0718517A2 (pt) 2013-11-19
AU2007298856A1 (en) 2008-03-27
SV2009003193A (es) 2010-02-01
CN101516881A (zh) 2009-08-26
TW200833329A (en) 2008-08-16
DE602007006525D1 (de) 2010-06-24
US20090253735A1 (en) 2009-10-08
ES2345016T3 (es) 2010-09-13
CN101516881B (zh) 2012-07-18
EA017442B1 (ru) 2012-12-28
IL197352A0 (en) 2009-12-24
CL2007002733A1 (es) 2008-04-11
ZA200901551B (en) 2010-06-30
MEP10709A (en) 2011-12-20
MA30792B1 (fr) 2009-10-01
ATE467633T1 (de) 2010-05-15
MX2009002802A (es) 2009-04-01
TN2009000081A1 (en) 2010-08-19
HN2009000502A (es) 2011-07-11
NO20091562L (no) 2009-04-20
IL197352A (en) 2014-11-30
US7915284B2 (en) 2011-03-29
JO2643B1 (en) 2012-06-17
HK1135388A1 (el) 2010-06-04
WO2008034974A1 (fr) 2008-03-27
GT200900049A (es) 2010-03-04
TWI381837B (zh) 2013-01-11
NI200900037A (es) 2014-02-20
JP5336378B2 (ja) 2013-11-06
HRP20100408T1 (hr) 2010-09-30
NZ575337A (en) 2011-12-22
PL2069342T3 (pl) 2010-10-29
EP2069342A1 (fr) 2009-06-17
PT2069342E (pt) 2010-07-19
AU2007298856B2 (en) 2012-08-09
AR062897A1 (es) 2008-12-10
KR20090054449A (ko) 2009-05-29
SI2069342T1 (sl) 2010-09-30
JP2010504309A (ja) 2010-02-12
CR10643A (es) 2009-04-29
CA2662848A1 (fr) 2008-03-27
EP2069342B1 (fr) 2010-05-12
MY145603A (en) 2012-03-15
UY30603A1 (es) 2008-05-02
UA95976C2 (en) 2011-09-26
EA200970311A1 (ru) 2009-08-28
RS51412B (en) 2011-02-28
FR2906250B1 (fr) 2008-10-31
CO6160308A2 (es) 2010-05-20
KR101470039B1 (ko) 2014-12-05

Similar Documents

Publication Publication Date Title
CY1110232T1 (el) Παραγωγα 2-αρυλ-6-φαινυλ-ιμιδαζο[1,2-α]πυριδιν, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη αγωγη
CY1123308T1 (el) Αναστολεας ινωσης
CY1113549T1 (el) Πολυυποκατεστημενα παραγωγα των 2-αρυλο-6-φαινυλ-ιμιδαζο[1,2-α]πυριδινων, η παρασκευη τους και η θεραπευτικη εφαρμογη τους
EA201071112A1 (ru) ПРОИЗВОДНЫЕ ПОЛИЗАМЕЩЁННЫХ 2-АРИЛ-6-ФЕНИЛИМИДАЗО[1,2-a]ПИРИДИНОВ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ ИХ В ТЕРАПИИ
CY1112997T1 (el) ΝΕΑ ΠΑΡΑΓΩΓΑ ΙΜΙΔΑΖΟ[1,5-α]ΠΥΡΙΔΙΝΩΝ, Η ΔΙΑΔΙΚΑΣIΑ ΠΑΡΑΣΚΕΥΗΣ ΤΟΥΣ ΚΑΙ ΟΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΑ ΠΕΡΙΕΧΟΥΝ
CY1111706T1 (el) Παραγωγα αρυλο- και ετεροαρυλο-πιπεριδινοκαρβοξυλικων αλατων, η παρασκευη τους και η εφαρμογη τους ως αναστολεις του ενζυμου faah
EA200702002A1 (ru) Замещённые производные пиразолилоксифенила, применяемые в качестве гербицидов
ATE556058T1 (de) 1-(2h)-isochinolonderivat
EA201170096A1 (ru) Замещенные производные пиримидона
CY1114836T1 (el) Παραγωγο δικυκλικου γ-αμινοξεος
CO6341631A2 (es) Derivados de 1,2,4 - oxadiazol y su uso terapéutico
CY1108792T1 (el) Παραγωγα διοξανιου-2-αλκυλκαρβαμικου, η παρασκευη τους και η εφαρμογη τους στην θεραπευτικη αγωγη
UY29690A1 (es) Derivados de n-(heteroaril)-1-heteroarilalquil-1h-indol-2-carboxamidas, su preparación y su aplicación en terapéutica.
NO20076006L (no) Acetylenderivater
AR086590A1 (es) Compuestos de ciclohexanona y herbicidas que los comprenden
CY1114767T1 (el) Ν,ν-υποκατεστημενες ενωσεις 3-αμινοπυρρολιδινης χρησιμες ως αναστολεις επαναπροσληψης μονοαμινων
CY1113911T1 (el) Παραγωγα sf5 ως αναστολεις par1, η παρασκευη τους και η χρηση τους ως φαρμακα
CY1110034T1 (el) Παραγωγα 1,2,4,5-τετραϋδρο-3h-βενζαζεπινων, μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα περιεχουν
CY1111601T1 (el) Παραγωγα καρβοξαμιδιων της τριαζολοπυριδινης, η παρασκευη τους και η θεραπευτικη χρηση τους
AR066605A1 (es) Derivados de heteroarilamida pirimidona
ECSP10010425A (es) Pirrolopirimidincarboxamidas
CY1107028T1 (el) Παραγωγα ινδανυλ-πιπεραζινων μεθοδος παρασκευης αυτων και οι φαρμακευτικες συνθεσεις που τα περιεχουν
CY1113535T1 (el) Παραγωγα κινολινης ως αντιβακτηριακοι παραγοντες
EA201170097A1 (ru) Замещенные трициклические производные против нейродегенеративных заболеваний
ATE517623T1 (de) Verwendung von methylphenidat-derivaten