MA52189A - Benzothiophènes et composés associés utilisés en tant qu'agonistes de sting - Google Patents
Benzothiophènes et composés associés utilisés en tant qu'agonistes de stingInfo
- Publication number
- MA52189A MA52189A MA052189A MA52189A MA52189A MA 52189 A MA52189 A MA 52189A MA 052189 A MA052189 A MA 052189A MA 52189 A MA52189 A MA 52189A MA 52189 A MA52189 A MA 52189A
- Authority
- MA
- Morocco
- Prior art keywords
- benzothiophens
- compounds used
- sting agonists
- associated compounds
- sting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862652018P | 2018-04-03 | 2018-04-03 | |
| US201962809956P | 2019-02-25 | 2019-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA52189A true MA52189A (fr) | 2021-02-17 |
Family
ID=66175500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA052189A MA52189A (fr) | 2018-04-03 | 2019-04-01 | Benzothiophènes et composés associés utilisés en tant qu'agonistes de sting |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10793557B2 (fr) |
| EP (1) | EP3774764A1 (fr) |
| JP (1) | JP7326319B2 (fr) |
| KR (1) | KR102755259B1 (fr) |
| CN (1) | CN111971277B (fr) |
| AU (1) | AU2019248545B2 (fr) |
| BR (1) | BR112020020085A8 (fr) |
| CA (1) | CA3095646A1 (fr) |
| MA (1) | MA52189A (fr) |
| MX (1) | MX2020010407A (fr) |
| TW (1) | TWI793294B (fr) |
| WO (1) | WO2019195124A1 (fr) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019046511A1 (fr) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | Composés, compositions et méthodes pour le traitement d'une maladie |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| CN111393405B (zh) * | 2019-01-02 | 2022-11-25 | 中国科学院上海药物研究所 | 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用 |
| CN118108716A (zh) | 2019-04-30 | 2024-05-31 | 四川科伦博泰生物医药股份有限公司 | 苯并噻吩类化合物及其制备方法和用途 |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| BR112022001931A2 (pt) | 2019-08-02 | 2022-06-21 | Mersana Therapeutics Inc | Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer |
| US20230032101A1 (en) * | 2019-10-28 | 2023-02-02 | Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences | Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof |
| US20230074558A1 (en) * | 2019-12-06 | 2023-03-09 | Mersana Therapeutics, Inc. | Dimeric compounds as sting agonists |
| US20230062932A1 (en) | 2019-12-18 | 2023-03-02 | Ctxt Pty Ltd | Compounds |
| CN113087668B (zh) * | 2019-12-23 | 2022-11-04 | 中国科学院上海药物研究所 | 一类苯并咪唑二聚体、其制备方法及用途 |
| CN113248475B (zh) * | 2020-02-11 | 2023-03-17 | 中国科学院上海药物研究所 | 一类杂环取代的苯并咪唑二聚体或其药学上可接受的盐、组合物及其用途 |
| WO2021202984A1 (fr) | 2020-04-02 | 2021-10-07 | Mersana Therapeutics, Inc. | Conjugués anticorps-médicament comprenant des agonistes de sting |
| WO2021206158A1 (fr) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | Méthode de cancérothérapie |
| US20230293716A1 (en) | 2020-05-08 | 2023-09-21 | Bolt Biotherapeutics, Inc. | Elastase-substrate, peptide linker immunoconjugates, and uses thereof |
| CN113861161A (zh) * | 2020-06-30 | 2021-12-31 | 上海海和药物研究开发股份有限公司 | 一种芳基并芳杂环衍生物及其制备方法和用途 |
| US11964978B2 (en) | 2021-03-18 | 2024-04-23 | Pfizer Inc. | Modulators of STING (stimulator of interferon genes) |
| CN117203194A (zh) * | 2021-03-30 | 2023-12-08 | 北京加科思新药研发有限公司 | 用作sting激动剂的新型化合物及其用途 |
| CN113429384B (zh) * | 2021-05-12 | 2022-04-08 | 中山大学附属第五医院 | 一类干扰素基因刺激因子靶向的放射性pet显像剂 |
| CN115772154B (zh) * | 2021-09-08 | 2024-04-30 | 上海交通大学 | 一类含有氘取代的苯并噻吩类衍生物及其制备与用途 |
| CN114213315A (zh) * | 2021-12-31 | 2022-03-22 | 上海陶术生物科技有限公司 | 含氮杂环类化合物及其中间体的合成方法 |
| KR20240148846A (ko) * | 2022-01-20 | 2024-10-11 | 오하이오 스테이트 이노베이션 파운데이션 | 지질 화합물을 포함하는 조성물과 이의 제조 및 사용 방법 |
| AU2023283720A1 (en) * | 2022-06-06 | 2025-01-02 | Sutro Biopharma, Inc. | Sting agonist compounds |
| WO2024032782A1 (fr) * | 2022-08-12 | 2024-02-15 | Jacobio Pharmaceuticals Co.Ltd. | Adjuvants de vaccin et leurs utilisations |
| WO2024137619A1 (fr) | 2022-12-20 | 2024-06-27 | Bolt Biotherapeutics, Inc. | Immunoconjugués agonistes de sting bis-benzimidazole, anti-claudine, et utilisations associées |
| WO2024175086A1 (fr) * | 2023-02-24 | 2024-08-29 | 深圳真实生物医药科技有限公司 | Agoniste de sting aryle tricyclique et son utilisation |
| WO2024186626A1 (fr) | 2023-03-03 | 2024-09-12 | Bolt Biotherapeutics, Inc. | Immunoconjugués d'agonistes de sting aza-bicycliques et leurs utilisations |
| CN116332903B (zh) * | 2023-03-29 | 2024-11-12 | 中国药科大学 | 一种具有苯并[b]硒吩结构的二聚化合物及其用途 |
| CN116354922A (zh) * | 2023-03-31 | 2023-06-30 | 药康众拓(江苏)医药科技有限公司 | 氘代苯并噻吩类化合物及其药物组合物和用途 |
| WO2025007743A1 (fr) * | 2023-07-04 | 2025-01-09 | Primelink Biotherapeutics (Shenzhen) Co., Ltd. | Agonistes de sting et leurs utilisations |
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| WO2019195063A1 (fr) | 2018-04-03 | 2019-10-10 | Merck Sharp & Dohme Corp. | Composés aza-benzothiophènes utilisés en tant qu'agonistes de sting |
-
2019
- 2019-04-01 CN CN201980024834.7A patent/CN111971277B/zh active Active
- 2019-04-01 KR KR1020207031242A patent/KR102755259B1/ko active IP Right Grant
- 2019-04-01 US US16/372,103 patent/US10793557B2/en active Active
- 2019-04-01 TW TW108111487A patent/TWI793294B/zh not_active IP Right Cessation
- 2019-04-01 MX MX2020010407A patent/MX2020010407A/es unknown
- 2019-04-01 CA CA3095646A patent/CA3095646A1/fr active Pending
- 2019-04-01 BR BR112020020085A patent/BR112020020085A8/pt unknown
- 2019-04-01 MA MA052189A patent/MA52189A/fr unknown
- 2019-04-01 AU AU2019248545A patent/AU2019248545B2/en active Active
- 2019-04-01 JP JP2020553626A patent/JP7326319B2/ja active Active
- 2019-04-01 WO PCT/US2019/025088 patent/WO2019195124A1/fr unknown
- 2019-04-01 EP EP19717660.5A patent/EP3774764A1/fr active Pending
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|---|---|
| TW202003509A (zh) | 2020-01-16 |
| CN111971277B (zh) | 2023-06-06 |
| EP3774764A1 (fr) | 2021-02-17 |
| US20190300513A1 (en) | 2019-10-03 |
| AU2019248545A1 (en) | 2020-10-15 |
| BR112020020085A8 (pt) | 2023-04-11 |
| KR20200139203A (ko) | 2020-12-11 |
| CA3095646A1 (fr) | 2019-10-10 |
| MX2020010407A (es) | 2020-10-22 |
| AU2019248545B2 (en) | 2022-08-11 |
| KR102755259B1 (ko) | 2025-01-15 |
| TWI793294B (zh) | 2023-02-21 |
| CN111971277A (zh) | 2020-11-20 |
| RU2020132585A (ru) | 2022-05-06 |
| JP2021520345A (ja) | 2021-08-19 |
| WO2019195124A1 (fr) | 2019-10-10 |
| BR112020020085A2 (pt) | 2021-02-17 |
| JP7326319B2 (ja) | 2023-08-15 |
| US10793557B2 (en) | 2020-10-06 |
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