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Security of Microfluidic Biochip: Practical Attacks and Countermeasures

Authors:

Seetal Potluri,

Farinaz KoushanfarAuthors Info & Claims

ACM Transactions on Design Automation of Electronic Systems (TODAES), Volume 25, Issue 3

Article No.: 27, Pages 1 - 29

https://doi.org/10.1145/3382127

Published: 21 April 2020 Publication History

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Abstract

With the advancement of system miniaturization and automation, Lab-on-a-Chip (LoC) technology has revolutionized traditional experimental procedures. Microfluidic Biochip (MFB) is an emerging branch of LoC with wide medical applications such as DNA sequencing, drug delivery, and point of care diagnostics. Due to the critical usage of MFBs, their security is of great importance. In this article, we exploit the vulnerabilities of two types of MFBs: Flow-based Microfluidic Biochip (FMFB) and Digital Microfluidic Biochip (DMFB). We propose a systematic framework for applying Reverse Engineering (RE) attacks and Hardware Trojan (HT) attacks on MFBs as well as for practical countermeasures against the proposed attacks. We evaluate the attacks and defense on various benchmarks where experimental results prove the effectiveness of our methods. Security metrics are defined to quantify the vulnerability of MFBs. The overhead and performance of the proposed attacks as well as countermeasures are also discussed.

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Published In

cover image ACM Transactions on Design Automation of Electronic Systems

ACM Transactions on Design Automation of Electronic Systems Volume 25, Issue 3

May 2020

179 pages

ISSN:1084-4309

EISSN:1557-7309

DOI:10.1145/3386183

Editor:
Naehyuck Chang
Korea Advanced Institute of Science and Technology, Korea

Issue’s Table of Contents

Copyright © 2020 ACM.

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ACM Journals for the Design of Smart and Connected Systems

Publication History

Published: 21 April 2020

Accepted: 01 January 2020

Revised: 01 April 2019

Received: 01 October 2017

Published in TODAES Volume 25, Issue 3

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Cited By

Zeng QLiu K(2025)Surface characterization and superhydrophilic properties of TiO2 nanopores prepared by multi-step anodizing processApplied Surface Science10.1016/j.apsusc.2025.162617690(162617)Online publication date: May-2025
https://doi.org/10.1016/j.apsusc.2025.162617
Dong CGuo XLian SYao YChen ZYang YLiu Z(2024)Harnessing the advances of MEDA to optimize multi-PUF for enhancing IP security of biochipsJournal of King Saud University - Computer and Information Sciences10.1016/j.jksuci.2024.10199636:3(101996)Online publication date: Mar-2024
https://doi.org/10.1016/j.jksuci.2024.101996
Majumdar RDatta PChowdhury SPal R(2024)Advancement with digital microfluidic biochips towards sustainability and secured outcome: a comprehensive survey on specific design metricsDiscover Electronics10.1007/s44291-024-00018-x1:1Online publication date: 5-Aug-2024
https://doi.org/10.1007/s44291-024-00018-x
Guo WLian SDong CChen ZHuang X(2022)A Survey on Security of Digital Microfluidic Biochips: Technology, Attack, and DefenseACM Transactions on Design Automation of Electronic Systems10.1145/349469727:4(1-33)Online publication date: 12-Feb-2022
https://dl.acm.org/doi/10.1145/3494697
Datta PChakraborty APal R(2022)Attack-Detection and -Recovery: An Integrated Approach Towards Attack-Tolerant Cyber-Physical Digital Microfluidic BiochipsIETE Journal of Research10.1080/03772063.2022.215070070:2(1449-1461)Online publication date: 5-Dec-2022
https://doi.org/10.1080/03772063.2022.2150700
Dong CLiu XXu YLian S(2022)Security and Innovation Protection of BiochipsHandbook of Biochips10.1007/978-1-4614-3447-4_62(927-947)Online publication date: 2-Feb-2022
https://doi.org/10.1007/978-1-4614-3447-4_62
Dong CLiu XXu YLian S(2021)Security and Innovation Protection of BiochipsHandbook of Biochips10.1007/978-1-4614-6623-9_62-1(1-21)Online publication date: 24-Mar-2021
https://doi.org/10.1007/978-1-4614-6623-9_62-1

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