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- research-articleSeptember 2024
pyCEPS: A cross-platform electroanatomic mapping data to computational model conversion platform for the calibration of digital twin models of cardiac electrophysiology
- Robert Arnold,
- Anton J. Prassl,
- Aurel Neic,
- Franz Thaler,
- Christoph M. Augustin,
- Matthias A.F. Gsell,
- Karli Gillette,
- Martin Manninger,
- Daniel Scherr,
- Gernot Plank
Computer Methods and Programs in Biomedicine (CBIO), Volume 254, Issue Chttps://doi.org/10.1016/j.cmpb.2024.108299Abstract Background and Objective:Data from electro-anatomical mapping (EAM) systems are playing an increasingly important role in computational modeling studies for the patient-specific calibration of digital twin models. However, data exported from ...
Highlights
- An open-source framework for managing electro-anatomical mapping data.
- Access and interrogate mapping data exported from clinical mapping systems.
- Conversion to modeling formats according to the openCARP standard.
- Make the ...
- research-articleJuly 2024
ForCEPSS—A framework for cardiac electrophysiology simulations standardization
- Matthias A.F. Gsell,
- Aurel Neic,
- Martin J. Bishop,
- Karli Gillette,
- Anton J. Prassl,
- Christoph M. Augustin,
- Edward J. Vigmond,
- Gernot Plank
Computer Methods and Programs in Biomedicine (CBIO), Volume 251, Issue Chttps://doi.org/10.1016/j.cmpb.2024.108189Abstract Background and Objective:Simulation of cardiac electrophysiology (CEP) is an important research tool that is increasingly being adopted in industrial and clinical applications. Typical workflows for CEP simulation consist of a sequence of ...
Highlights
- Open-source framework for standardizing cardiac electrophysiology simulations.
- Built upon cardiac electrophysiology modeling community standard software, the openCARP simulator and the carputils framework.
- Simplifies model ...
- ArticleJune 2023
Effect of Varying Pericardial Boundary Conditions on Whole Heart Function: A Computational Study
- Justina Ghebryal,
- Cristobal Rodero,
- Rosie K. Barrows,
- Marina Strocchi,
- Caroline H. Roney,
- Christoph M. Augustin,
- Gernot Plank,
- Steven A. Niederer
Functional Imaging and Modeling of the HeartPages 545–554https://doi.org/10.1007/978-3-031-35302-4_56AbstractPericardiectomy is recommended therapy for pericarditis, an inflammation of the pericardial layers that surround the heart and play a central role in maintaining cardiac performance. In some cases, the pericardium can be repaired or patched. ...
- research-articleApril 2023
Mechanoelectric effects in healthy cardiac function and under Left Bundle Branch Block pathology
- Argyrios Petras,
- Matthias A.F. Gsell,
- Christoph M. Augustin,
- Jairo Rodriguez-Padilla,
- Alexander Jung,
- Marina Strocchi,
- Frits W. Prinzen,
- Steven A. Niederer,
- Gernot Plank,
- Edward J. Vigmond
Computers in Biology and Medicine (CBIM), Volume 156, Issue Chttps://doi.org/10.1016/j.compbiomed.2023.106696AbstractMechanoelectric feedback (MEF) in the heart operates through several mechanisms which serve to regulate cardiac function. Stretch activated channels (SACs) in the myocyte membrane open in response to cell lengthening, while tension generation ...
Highlights- The role of mechanoelectric feedback mechanisms in the cardiac function is explored.
- An in-silico study using a biventricular canine cardiac geometry is conducted.
- The study uses 3D-0D fluid-electromechanical framework implemented ...
- research-articleOctober 2022
A coupling strategy for a first 3D-1D model of the cardiovascular system to study the effects of pulse wave propagation on cardiac function
Computational Mechanics (SPCM), Volume 70, Issue 4Pages 703–722https://doi.org/10.1007/s00466-022-02206-6AbstractA key factor governing the mechanical performance of the heart is the bidirectional coupling with the vascular system, where alterations in vascular properties modulate the pulsatile load imposed on the heart. Current models of cardiac ...
- research-articleAugust 2022
Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration
- Laura Marx,
- Justyna A. Niestrawska,
- Matthias A.F. Gsell,
- Federica Caforio,
- Gernot Plank,
- Christoph M. Augustin
Journal of Computational Physics (JOCP), Volume 463, Issue Chttps://doi.org/10.1016/j.jcp.2022.111266AbstractImage-based computational models of the heart represent a powerful tool to shed new light on the mechanisms underlying physiological and pathological conditions in cardiac function and to improve diagnosis and therapy planning. However,...
Graphical abstract Highlights- Novel fitting method to find personalized passive material parameters.
- The ...
- research-articleSeptember 2021
The openCARP simulation environment for cardiac electrophysiology
- Gernot Plank,
- Axel Loewe,
- Aurel Neic,
- Christoph Augustin,
- Yung-Lin Huang,
- Matthias A.F. Gsell,
- Elias Karabelas,
- Mark Nothstein,
- Anton J. Prassl,
- Jorge Sánchez,
- Gunnar Seemann,
- Edward J. Vigmond
Computer Methods and Programs in Biomedicine (CBIO), Volume 208, Issue Chttps://doi.org/10.1016/j.cmpb.2021.106223Highlights- We present the openCARP simulation environment as a solution that could foster the needs of large parts of the computational cardiac electrophysiology ...
Background and Objective: Cardiac electrophysiology is a medical specialty with a long and rich tradition of computational modeling. Nevertheless, no community standard for cardiac electrophysiology simulation software has evolved yet. ...
- ArticleJune 2021
The Effect of Ventricular Myofibre Orientation on Atrial Dynamics
- research-articleJanuary 2016
Anatomically accurate high resolution modeling of human whole heart electromechanics
- Christoph M. Augustin,
- Aurel Neic,
- Manfred Liebmann,
- Anton J. Prassl,
- Steven A. Niederer,
- Gundolf Haase,
- Gernot Plank
Electromechanical (EM) models of the heart have been used successfully to study fundamental mechanisms underlying a heart beat in health and disease. However, in all modeling studies reported so far numerous simplifications were made in terms of ...