CRYZ

CRYZ
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1YB5
Identifikatori
Aliasi	CRYZ
Vanjski ID-jevi	OMIM: 123691 MGI: 88527 HomoloGene: 133907 GeneCards: CRYZ
Lokacija gena (čovjek)
Hrom.	Hromosom 1 (čovjek)
Kraj	74,733,408 bp
Lokacija gena (miš)
Hrom.	Hromosom 3 (miš)
Kraj	154,623,182 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• oxidoreductase activity; • vezivanje iona cinka; • NADPH binding; • NADPH:quinone reductase activity; • NADH binding; • vezivanje sa RNK; • mRNA 3'-UTR binding;
Ćelijska komponenta	• citosol; • Egzosom; • citoplazma;
Biološki proces	• protein homotetramerization; • xenobiotic catabolic process; • Vid;
	Izvori:Amigo / QuickGO
Ortolozi
	1429
	12972
	ENSG00000116791
	ENSMUSG00000028199
	Q08257
	P47199
	NM_001130042; NM_001130043; NM_001134759; NM_001889
	NM_009968
	NP_001123514; NP_001123515; NP_001128231; NP_001880
NP_034098; NP_001344601; NP_001344602; NP_001344603; NP_001344604;
	NP_001344605
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Kinon-oksidoreduktaza jest enzim koji je kod ljudi kodiran genom CRYZ sa hromosoma 1.^[5]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 329 aminokiselina, a molekulska težina 35.207 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MATGQKLMRA	VRVFEFGGPE	VLKLRSDIAV	PIPKDHQVLI	KVHACGVNPV
ETYIRSGTYS	RKPLLPYTPG	SDVAGVIEAV	GDNASAFKKG	DRVFTSSTIS
GGYAEYALAA	DHTVYKLPEK	LDFKQGAAIG	IPYFTAYRAL	IHSACVKAGE
SVLVHGASGG	VGLAACQIAR	AYGLKILGTA	GTEEGQKIVL	QNGAHEVFNH
REVNYIDKIK	KYVGEKGIDI	IIEMLANVNL	SKDLSLLSHG	GRVIVVGSRG
TIEINPRDTM	AKESSIIGVT	LFSSTKEEFQ	QYAAALQAGM	EIGWLKPVIG
SQYPLEKVAE	AHENIIHGSG	ATGKMILLL

Funkcija

Kristalini se dijele u dvije klase: specifične za taksone ili enzime i sveprisutne. Potonja klasa čini glavne proteine kičmenjaka očne leće i održava transparentnost i indeks prelamanja sočiva. Prva klasa se naziva i filogenetski ograničeni kristalini. Ovaj gen kodira kristalinski protein specifičan za takson koji ima NADPH-ovisnu aktivnost kinon-reduktaze, različitu od drugih poznatih kinon-reduktaza. Nedostaje mu aktivnost alkohol-dehidrogenaza, iako se po sličnosti smatra članom porodice alkohol-dehidrogenaza koje sadrže cink. Za razliku od drugih sisarskih vrsta, kod ljudskih sočiva ekspresija je niska. Poznato je da postoji jedan pseudogen.^[5]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116791 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028199 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CRYZ crystallin, zeta (quinone reductase)".
^ "UniProt, Q08257" (jezik: engleski). Pristupljeno 23. 11. 2021.

Dopunska literatura

Heinzmann C, Kojis TL, Gonzalez P, et al. (1995). "Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms". Genomics. 23 (2): 403–7. doi:10.1006/geno.1994.1516. PMID 7835889.
Gonzalez P, Rao PV, Zigler JS (1994). "Organization of the human zeta-crystallin/quinone reductase gene (CRYZ)". Genomics. 21 (2): 317–24. doi:10.1006/geno.1994.1272. PMID 8088825.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gonzalez P, Rao PV, Zigler JS (1993). "Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver". Biochem. Biophys. Res. Commun. 191 (3): 902–7. doi:10.1006/bbrc.1993.1302. PMID 8466529.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Wang W, Liu LQ, Higuchi CM, Chen H (1998). "Induction of NADPH:quinone reductase by dietary phytoestrogens in colonic Colo205 cells". Biochem. Pharmacol. 56 (2): 189–95. doi:10.1016/S0006-2952(98)00141-5. PMID 9698072.
Goenka S, Raman B, Ramakrishna T, Rao CM (2001). "Unfolding and refolding of a quinone oxidoreductase: alpha-crystallin, a molecular chaperone, assists its reactivation". Biochem. J. 359 (Pt 3): 547–56. doi:10.1042/0264-6021:3590547. PMC 1222175. PMID 11672428.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bianco NR, Perry G, Smith MA, et al. (2004). "Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage". Mol. Endocrinol. 17 (7): 1344–55. doi:10.1210/me.2002-0382. PMID 12714703.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

Vanjski linkovi

Lokacija ljudskog genoma CRYZ i stranica sa detaljima o genu CRYZ u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116791 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028199 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CRYZ crystallin, zeta (quinone reductase)".

[UniProt-6] "UniProt, Q08257" (jezik: engleski). Pristupljeno 23. 11. 2021.

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p r u Enzimi
Teme	Aktivno mjesto Alosterna regulacija Difuzijski limitirani enzim EC broj Enzimska kataliza Inhibicija enzimskih reakcija Kinetika enzima Koenzim Kooperativnost Lineweaver–Burkov dijagram Michaelis–Mentenova kinetika Mjesto vezanja Spisak enzima
Tipovi	EC1 Oksidoreduktaze/spisak EC2 Transferaze/spisak EC3 Hidrolaze/spisak EC4 Lijaze/spisak EC5 Izomeraze/spisak EC6 Ligaze/spisak