CCL23

Pretraga za
Strukture	Swiss-model
Domene	InterPro

Hemokinski (C-C motivni) ligand 23
Hemokinski (C-C motivni) ligand 23
Identifikatori
Simbol	CCL23
Alt. simboli	SCYA23, Ckb-8, MPIF-1, MIP-3, CKb8
NCBI gen	6368
HGNC	10622
OMIM	602494
PDB	1G91
RefSeq	NM_005064
UniProt	P55773
Ostali podaci
Lokus	Hrom. 17 q11.2
Strukture
Pretraga za
Strukture	Swiss-model
Domene	InterPro

CCL23
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1G91
Identifikatori
Aliasi	CCL23
Vanjski ID-jevi	OMIM: 602494 MGI: 98263 HomoloGene: 89167 GeneCards: CCL23
Lokacija gena (čovjek)
Hrom.	Hromosom 17 (čovjek)
Kraj	36,017,972 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	83,483,913 bp
Ontologija gena
Molekularna funkcija	• cytokine activity; • heparin binding; • chemokine activity; • CCR1 chemokine receptor binding; • CCR chemokine receptor binding;
Ćelijska komponenta	• extracellular region; • Vanćelijsko;
Biološki proces	• G protein-coupled receptor signaling pathway; • monocyte chemotaxis; • chemokine-mediated signaling pathway; • cell-cell signaling; • cellular response to tumor necrosis factor; • cellular calcium ion homeostasis; • neutrophil chemotaxis; • Hemotaksija; • negative regulation of C-C chemokine binding; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 Imuni odgovor; • cellular response to interleukin-1; • positive regulation of ERK1 and ERK2 cascade; • cellular response to interferon-gamma; • lymphocyte chemotaxis; • GO:0072468 Transdukcija signala; • negative regulation of cell population proliferation; • inflammatory response; • regulation of signaling receptor activity; • eosinophil chemotaxis;
	Izvori:Amigo / QuickGO
Ortolozi
	6368
	20305
	ENSG00000276114; ENSG00000274736
	ENSMUSG00000018927
	P55773
	P27784
	NM_005064; NM_145898
	NM_009139
	NP_005055; NP_665905
	NP_033165
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Hemokinski (C-C motivni) ligand 23 (CCL23) je mali citokin koji pripadaju porodici CC hemokina, poznatoj i kao makrofagni upalni protein 3 (MIP-3) i mijeloidni progenitorski inhibitorni faktor 1 (MPIF-1). CCL23 se pretežno eksprimira u tkivima pluća i jetre , ali također i u koštanoj srži i posteljicama.^[5] Eksprimira se i u nekim ćelijskim linijama mijeloidnog porijekla. CCL23 je vrlo hemotaktičan za mirovanje T-ćelija i monocita i blago hemotaktičan za neutrofile. Također se pripisuje inhibitornoj aktivnosti na prekursorima hematopoetskih ćelija.^[5] Gen za CCL23 nalazi se na ljudskom hromosomu 17 u lokusu koji sadrži nekoliko drugih CC-hemokina. CCL23 je ligand za hemokinski receptor CCR1.^[6]

Aminokiselinska sekvenca

Dužina polipeptidnog lanca je 120 aminokiselina, a molekulska težina 13.411 Da^[7].

Simboli

C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin

L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin

10	20	30	40	50
MKVSVAALSC	LMLVTALGSQ	ARVTKDAETE	FMMSKLPLEN	PVLLDRFHAT
SADCCISYTP	RSIPCSLLES	YFETNSECSK	PGVIFLTKKG	RRFCANPSDK
QVQVCVRMLK	LDTRIKTRKN

Reference

^ ^a ^b ^c ENSG00000274736 GRCh38: Ensembl release 89: ENSG00000276114, ENSG00000274736 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018927 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Patel et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997.
^ Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.
^ "UniProt, P55773". Pristupljeno 26. 6. 2021.

Vanjski linkovi

[refGRCh38Ensembl-1] ENSG00000274736 GRCh38: Ensembl release 89: ENSG00000276114, ENSG00000274736 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018927 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[patel-5] Patel et al. Molecular and functional characterization of two novel human C-C chemokines as inhibitors of two distinct classes of myeloid progenitors. J. Exp. Med. 185: 1163-1172, 1997.

[6] Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.

[UniProt-7] "UniProt, P55773". Pristupljeno 26. 6. 2021.

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