CpG 메틸화는 배아 발달, 각인, X-크롬 불활성화에 중요한 후생유전학적 수정이다.쥐에 대한 연구는 포유류 발달에 DNA 메틸화가 필요하다는 것을 증명했다.이 유전자는 DNA 메틸트랜스퍼레이즈를 인코딩하는데, 이는 유지 관리 메틸화가 아닌 디노보 메틸화에서 기능한다고 생각된다.단백질은 주로 핵에 국소화되며 그 표현은 발달에 따라 조절된다.8개의 대안으로 분할된 대본 변형이 설명되었다.변형 4와 5의 전체 길이 순서는 결정되지 않았다.[5]
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^ abKang ES, Park CW, Chung JH (December 2001). "Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1". Biochemical and Biophysical Research Communications. 289 (4): 862–8. doi:10.1006/bbrc.2001.6057. PMID11735126.
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