Jashore University of Science and Technology: Pantoprazole
Jashore University of Science and Technology: Pantoprazole
Jashore University of Science and Technology: Pantoprazole
Department of Pharmacy
Course title: Human Physiology and Anatomy-IV
Course code: Phar-2209
An assignment
on
Pantoprazole
Submitted by Submitted to
Name: Abir Hasan Sajid Md Nazmul Hasan Zilani
ID: 181035 Lecturer
2nd year, 2nd semester Department of Pharmacy
Session: 2018-19 Jashore University of Science and
Department of Pharmacy Technology
Jashore University of Science and
Technology
Molecular
Introduction Machanism
Indication
Side
effects
Pharmaco
Contents kinetics
Drug
Interaction
Dose,dosage
form ,strength
Precaution,
contraindication Metabolism
Introduction
Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric
acid production by covalently binding to the H+/K+ATPase enzyme system at the surface
of the gastric parietal cell. H+/K+ ATPase is nothing but proton pump.
Known as
Prodrug
Proton pump
(requires activation)
inhibitor (PPI)
Pyridine ring
-prazole
Within the gastric parietal cells, water and CO2 combine and produce t
he carbonic acid by carbonic anhydrase enzyme. HCO 3-
Cl - HCO3- H 2 O+CO2
Then carbonic acid split into carbonate ion and proton
CA
H 2 CO2
Bicarbonate exchange outside with Chloride ion by another pump
2H+
-H +
It can treat gastro esophagus reflux disorder by reducing gastric acid secretion. Where gastric acid
reflux into esophagus.
In triple and quadrupole therapy, It can treat infection in the gastric wall caused by a gram –ve bacteri
a named Helicobacter pylori.
It reduced acid secretion caused by zollinger addisons sundrome in which tumor cause stomach to
produce more acid.
Gastro esophagus
reflux disorder
Helicobacter-
Pantoprazole
pylori eradication
Zollinger ellison
syndrome
With NSAIDs
Drug Interaction
PPI‘s are generally inhibit the CYP450 enzyms and one of the important CYP450 enzyme
on which PPI’s act is CYP2C19.
Some drugs are activated by this enzyme. Such as Clopidogrel,Nelfinavin,Rilpirivine.
So when these drugs are adminstrated with PPI’s,these drug‘s metabolism can be inhibited
by the PPI’s that is mainly for the inhibition of enzyme CYP2C19. Though pantoprazole is less
inhibitory among the other PPI’s
Reduced
Nelfinavir Inhibited CYP2C19 Active M8 metabolite Nelfinavir effect
Diarrhoea Abdom-in
al pain
Bone
fracture
Abdominal pain Headache
Precaution and warnings!
Patients should be cautioned that Pantoprazole tablet should not be split, chewed or crushed.
Contraindication
Pantoprazole is contraindicated in patients with known hypersensitivity to any of the
components of the formulation.
https://reference.medscape.com/drug/protonix-pantoprazole-342001#10
https://www.sciencedirect.com/topics/chemistry/pantoprazole
https://www.pediatriconcall.com/drugs/pantoprazole/850
https://youtu.be/V0HR-ojkURw
https://medex.com.bd/generics/859/pantoprazole/brand-names
https://en.m.wikipedia.org/wiki/Pantoprazole