Nothing Special   »   [go: up one dir, main page]
Scribd Logo
Upload

Welcome to Scribd!

  • 32 views

    Malignant Nephrosclerosis

    Uploaded by

    Isfahan Masulot
    Malignant nephrosclerosis is a disease characterized by vascular damage to the kidneys that is usually caused by long-standing hypertension. Microscopically, it shows fibrinoid necrosis of arterioles, fibrin deposition, and intimal thickening of arteries and arterioles. Clinically, it presents as malignant hypertension with systolic pressures over 200 mm Hg and diastolic pressures over 120 mm Hg, as well as papilledema, retinal hemorrhages, and encephalopathy. Treatment involves controlling blood pressure with ACE inhibitors, angiotensin receptor blockers, or aliskiren. Most patients survive 5 years with treatment and restoration of renal function.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd

    Malignant Nephrosclerosis

    Uploaded by

    Isfahan Masulot
    32 views3 pages
    Malignant nephrosclerosis is a disease characterized by vascular damage to the kidneys that is usually caused by long-standing hypertension. Microscopically, it shows fibrinoid necrosis of arterioles, fibrin deposition, and intimal thickening of arteries and arterioles. Clinically, it presents as malignant hypertension with systolic pressures over 200 mm Hg and diastolic pressures over 120 mm Hg, as well as papilledema, retinal hemorrhages, and encephalopathy. Treatment involves controlling blood pressure with ACE inhibitors, angiotensin receptor blockers, or aliskiren. Most patients survive 5 years with treatment and restoration of renal function.

    Original Description:

    Original Title

    Malignant nephrosclerosis.doc

    Copyright

    © © All Rights Reserved

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Malignant nephrosclerosis is a disease characterized by vascular damage to the kidneys that is usually caused by long-standing hypertension. Microscopically, it shows fibrinoid necrosis of arterioles, fibrin deposition, and intimal thickening of arteries and arterioles. Clinically, it presents as malignant hypertension with systolic pressures over 200 mm Hg and diastolic pressures over 120 mm Hg, as well as papilledema, retinal hemorrhages, and encephalopathy. Treatment involves controlling blood pressure with ACE inhibitors, angiotensin receptor blockers, or aliskiren. Most patients survive 5 years with treatment and restoration of renal function.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    32 views3 pages

    Malignant Nephrosclerosis

    Uploaded by

    Isfahan Masulot
    Malignant nephrosclerosis is a disease characterized by vascular damage to the kidneys that is usually caused by long-standing hypertension. Microscopically, it shows fibrinoid necrosis of arterioles, fibrin deposition, and intimal thickening of arteries and arterioles. Clinically, it presents as malignant hypertension with systolic pressures over 200 mm Hg and diastolic pressures over 120 mm Hg, as well as papilledema, retinal hemorrhages, and encephalopathy. Treatment involves controlling blood pressure with ACE inhibitors, angiotensin receptor blockers, or aliskiren. Most patients survive 5 years with treatment and restoration of renal function.

    Copyright:

    © All Rights Reserved
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 3

    MASULOT, ISFAHAN B.

    Disease Etiology Pathology Histologic Incidence Clinical presentation Treatment Prognosis


    feature/morphology
    #158  Usually arises 1. vascular damage Gross:  Malignant 1. systolic  angiotensin 75% of patients
    -Malignant from preexisting to the kidneys hypertension pressures converting survive 5 years,
     Small, 
    Nephrosclero essential from a variety of is relatively greater than 200 enzyme and 50% survive
    pinpoint 
    sis hypertension disorders uncommon, mm Hg and (ACE) with restoration
    petechial
     secondary forms 2. endothelial injury occurring in diastolic inhibitors of pre-crisis
    hemorrhages
    of hypertension 3. increased 1% to 5% of pressures renal function
     may   Aliskiren
     glomerulonephritis permeability of the all people greater than 120
    appear on  150-
     reflux small vessels to with elevated mm Hg
    the cortical  300mg/day
    nephropathy fibrinogen and blood pressure
    surface  2. papilledema
    other plasma  more often in  angiotensin
    from 
    proteins men and in 3. retinal receptor
    rupture of 
    4. focal death of cells blacks hemorrhages blockers
    arterioles 
    of the vascular
    or  4. encephalopathy
    wall
    glomerular 
    5. platelet deposition 5. cardiovascular
    capillaries
    6. fibrinoid necrosis abnormalities
    of arterioles and  “flea-bitten” 
    6. renal failure
    small arteries appearance
    7. hyperplasia of 7. scotomas or
    intimal smooth spots before the
    muscle of vessels eyes
    8. kidneys become
    markedly ischemic 8. increased
    9. elevated levels of intracranial
    Microscopic:
    plasma renin pressure
     Fibrinoid
    10. intrarenal
    necrosis of 9. “Hypertensive
    vasoconstriction
    arterioles crises
     smudgy 
    10. marked
    eosinophilic 
    proteinuria
    appearance
     fibrin  11. microscopic or
    deposition macroscopic
     intimal  hematuria
    thickening of
     
    interlobular 
    arteries 
    and 
    arterioles
     onion-skinning
     hyperplastic
    arteriolitis

    You might also like