I found this film after reading a Danny Pudi interview, as I'm a huge fan of Community and Abed is definitely my favorite character. I wanted to enjoy this film. But, it felt incredibly artificial from the first moments. I found the performances by Danny Pudi and Lance Henriksen (the best-friend's father) to both be quite good, even great at moments, but the less than adequate quality of the script and production ended up making even their performances feel forced. The "craig's list girl", Diana DeGarmo, may have given the most convincing performance in the film, unfortunately her role was only secondary. Much of the film's dialogue was cringe-worthy and didn't feel remotely realistic/relatable. There were often moments throughout the film that presented themselves as profound, queue panning landscape or close-up of Danny Pudi pondering life, but the story just fell flat every time. From my humble perspective the blame seems to fall on the production team more so than the cast, in this one. As I'm not familiar with all these actors, some of them may have solid performances in other films.But, this isn't going to be on that list. If you want a great performance from Danny Pudi, go see all of Community. If you want to see an art-film about depression or family dynamics, you're better off looking to Garden State or Melancholia.
TLDR: If you are die-hard fan of one of these actors, give it a light-watch. But, don't expect to see something profound, in any way.