- Known for his talent with dialects, his first three years of his career had him playing Latinos, including a three-month stint on The Brighter Day (1954) as a Cuban heavy.
- He has played the same character (Dr. Adam Bricker) in four different series: The Love Boat (1977), Charlie's Angels (1976), Martin (1992) and Love Boat: The Next Wave (1998).
- Bernie and Catrina Honadle are parents of Joshua Grant (b. 1997) and Adam Alexander (b. 2002) who is named for Kopell's The Love Boat (1977) character, Dr. Adam Bricker.
- Friends with Gavin MacLeod, Bill Bixby, Shirley Jones, Dick Van Patten, Elizabeth Montgomery, Katherine Helmond, and Robert Fuller.
- Served in the United States Navy, under the service number 488 29 39, from December 1955 to September 1957. Was released from active duty as a Seaman and discharged from the Inactive Reserves in December 1961.
- Best known for his role as Dr. Adam Bricker on The Love Boat (1977).
- Went to college with James Drury.
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