Local CryoEM structure of the SARS-CoV-2 BA.5 in complex with ORB10 Fab
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8zpp
Q-score: 0.477
To Be Published
- Variable heavy chain of orb10 fab (13 kDa, Protein from Mus musculus)
- Sars-cov-2 ba.5 spike in complex with orb10 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Variable light chain of orb10 fab (11 kDa, Protein from Mus musculus)
- Spike glycoprotein,fibritin (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8v5v
Q-score: 0.421
Olmedillas E, Diaz R, Hastie K, Ollmann-Saphire E
To Be Published
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of a sars-cov-2 spike s2 subunit in a pre-fusion, open conformation (Complex from Mus musculus molossinus)
- Variable domain of the light chain from the human antibody 6c10 (11 kDa, Protein from Homo sapiens)
- Fab fragment of the 6c10 human monoclonal antibody (Complex from Homo sapiens)
- Spike protein s2,fibritin (64 kDa, Protein from Tequatrovirus T4)
- Variable domain of the heavy chain from the human antibody 6c10 (13 kDa, Protein from Homo sapiens)
- Structure of a sars-cov-2 spike s2 subunit in a pre-fusion, open conformation in complex with the 6c10 fab (280 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of the Sars-Cov2 S trimer without RBDs
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8r87
Q-score: 0.496
Letscher H, Guilligay D, Sulbaran G, Amen A, Effantin G, Dereuddre-Bosquet N, Burger JA, Poniman M, Grobben M, Dergan Dylon S, Lemaitre J, Gros W, Galllouet A, Herate C, Relouzat F, Schoehn G, van der Werf S, van Gils MJ, Sanders RW, Poignard P, Le Grand R, Weissnhorn W
To Be Published
SARS-CoV-2 Spike protein Beta Variant at 4C structural flexibility / heterogeneity analyses
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9gdx
Q-score: 0.285
Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM
bioRxiv (2024) [ Pubmed: 39345408 DOI: doi:10.1101/2024.09.16.613176 ]
SARS-CoV-2 Spike protein Beta Variant at 37C structural flexibility / heterogeneity analyses
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 9gdy
Q-score: 0.239
Herreros D, Mata CP, Noddings C, Irene D, Krieger J, Agard DA, Tsai MD, Sorzano COS, Carazo JM
bioRxiv (2024) [ Pubmed: 39345408 DOI: doi:10.1101/2024.09.16.613176 ]
SARS-CoV-2 BA-2.87.1 Spike ectodomain
Duyvesteyn HME, Dijokaite-Guraliuc A, Liu C, Supasa P, Kronsteiner B, Jeffery K, Stafford L, Klenerman P, Dunachie SJ, Mongkolsapaya J, Fry EE, Ren J, Stuart DI, Screaton GR
Structure (2024) 32 pp. 1594- [ Pubmed: 39173622 DOI: doi:10.1016/j.str.2024.07.020 ]
Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6
Bjoernsson KH, Walker MR, Raghavan SSR, Ward AB, Barfod LK
To Be Published
- Antibody (Complex from Homo sapiens)
- Spike glycoprotein,fibritin (141 kDa, Protein from Enterobacteria phage T4)
- K501sp6 fv heavy chain (14 kDa, Protein from Homo sapiens)
- Alphacoronavirus (Complex)
- Spike glycoprotein with fibritin (Complex from Severe acute respiratory syndrome coronavirus 2)
- K501sp6 fv light chain (14 kDa, Protein from Homo sapiens)
Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8oyt
Q-score: 0.161
Cornish K, Huo J, Jones L, Sharma P, Thrush JW, Abdelkarim S, Kipar A, Ramadurai S, Weckener M, Mikolajek H, Liu S, Buckle I, Bentley E, Kirby A, Han X, Laidlaw SM, Hill M, Eyssen L, Norman C, Le Bas A, Clarke J, James W, Stewart JP, Carroll M, Naismith JH, Owens RJ
Open Biol (2024) 14 pp. 230252-230252 [ Pubmed: 38835241 DOI: doi:10.1098/rsob.230252 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Complex of stabilised hexapro omicron ba.1 spike trimer with three h6 nanobodies (Complex)
- Stabilised hexapro omicron ba.1 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- H6 nanobody (Complex from Lama glama)
- H6 nanobody (14 kDa, Protein from Lama glama)
- Spike glycoprotein,fibritin (140 kDa, Protein from Tequatrovirus T4)
SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
Resolution: 2.68 Å
EM Method: Single-particle
Fitted PDBs: 8c0y
Q-score: 0.491
Sheward DJ, Pushparaj P, Das H, Greaney AJ, Kim C, Kim S, Hanke L, Hyllner E, Dyrdak R, Lee J, Dopico XC, Dosenovic P, Peacock TP, McInerney GM, Albert J, Corcoran M, Bloom JD, Murrell B, Karlsson Hedestam GB, Hallberg BM
Cell Rep Med (2024) 5 pp. 101577-101577 [ Pubmed: 38761799 DOI: doi:10.1016/j.xcrm.2024.101577 ]
- Sars-cov2 omicron ba.1 spike in complex with cab-a17 antibody (95 kDa, Complex)
- Cab-a17 antibody (variable) (12 kDa, Protein from Homo sapiens)
- Spike protein s2' (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cab-a17 antibody (variable) (11 kDa, Protein from Homo sapiens)
- Cab-a17 antibody (fab) (Complex from Enterobacteria phage T4)
- Sars-cov-2 omicron rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
Prefusion RSV F Bound to Lonafarnib and D25 Fab
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8kg5
Q-score: 0.499
Yang Q, Xue B, Liu F, Lu Y, Tang J, Yan M, Wu Q, Chen R, Zhou A, Liu L, Liu J, Qu C, Wu Q, Fu M, Zhong J, Dong J, Chen S, Wang F, Zhou Y, Zheng J, Peng W, Shang J, Chen X
Signal Transduct Target Ther (2024) 9 pp. 144-144 [ Pubmed: 38853183 DOI: doi:10.1038/s41392-024-01858-5 ]
- Fusion glycoprotein f0,fibritin (64 kDa, Protein from Enterobacteria phage T4)
- Prefusion rsv f bound to lonafarnib and d25 fab (Complex from Human respiratory syncytial virus A (strain A2))
- 4-{2-[4-(3,10-dibromo-8-chloro-6,11-dihydro-5h-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidin-1-yl]-2-oxoethyl}piperidine-1-carboxamide (638 Da, Ligand)
- D25 heavy chain (24 kDa, Protein from Homo sapiens)
- D25 light chain (23 kDa, Protein from Homo sapiens)