Ambroxol Hydrochloride

A  simple,  robust,  precise  HPLC  method  was  developed  and  the
method  has  been  validated  for  the  estimation  of  valsartan  and
nebivolol  simultaneously  in  its  combined  dosage  forms  as  well  as
individual formulations. Both the compounds are well resolved in a
isocratic  method  by  using  the  mobile  phase  composition  of
acetonitrile: methanol: pH4.0 0.02M Potassium hydrogen phosphate
buffer in the ratio of 50:20:30 v/v at a flow rate of 1.0mL/min using a
C-18 column. The detection was carried out at 210nm.. The retention
time  of  Nebivolol  and  Valsartan  were  2.5  min  and  4.3  min
respectively.  The  developed  method  was  validated  for  specificity,
linearity,  precision,  accuracy,  limit  of  detection  (LOD),  limit  of
quantification (LOQ) and robustness as per ICH guidelines. Linearity
for Nebivolol and Valsartan were found in the range of 48-112 µg/ml
and  3.0-7.0  µg/ml,  respectively.  The  percentage  recoveries  for
Nebivolol  and  Valsartan  ranged  from  98.9-100.8  %  and  98.9-101.1
%,  respectively.  The  proposed  method  could  be  used  for  routine
analysis of Nebivolol and Valsartan in their combined dosage forms

The current study was aimed to develop the meclizine hydrochloride
sublimated fast dissolving tablets using different sublimated agents to
enhance the dissolution rate. The prepared fast dissolving tablets
were subjected to pre-compression properties and characterized for
hardness, weight variation, friability, wetting time, water absorption
ratio, and disintegration time. From In vitro dissolution studies, the
formulation F3 containing camphor (10%w/w) as the sublimating
agent showed rapid dissolution of about 98.61% in 30 min, and
disintegration time 43 sec when compared with other sublimating
agents. The percent drug release in 30 min (Q30) and initial
dissolution rate for formulation F3 was 98.61±0.25%, 3.29%/min.
These were very much higher compared to marketed tablets
(65.43±0.57%, 2.18%/min). The dissolution efficiency was found to
be 63.37 and it is increased by 1.4 fold with F3 FDT tablets
compared to marketed tablets. Differential scanning calorimetry and
Fourier transform infrared spectroscopy studies revealed that there
was no possibility of interactions. In conclusion, development of
meclizine hydrochloride fast dissolving tablets by sublimation
method is an appropriate method to enhance the dissolution rate.