GPR77
| G protein-spregnuti receptor 77 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||||
| Simboli | GPR77; C5L2; GPF77 | ||||||||||
| Vanjski ID | OMIM: 609949 MGI: 2442013 HomoloGene: 49549 IUPHAR: C5L2 GeneCards: GPR77 Gene | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 27202 | 319430 | |||||||||
| Ensembl | ENSG00000134830 | ENSMUSG00000074361 | |||||||||
| UniProt | Q9P296 | n/a | |||||||||
| RefSeq (mRNA) | NM_018485 | NM_176912 | |||||||||
| RefSeq (protein) | NP_060955 | NP_795886 | |||||||||
| Lokacija (UCSC) |
Chr 19: 52.54 - 52.54 Mb |
Chr 7: 15.4 - 15.4 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
GPR77, G protein-spregnuti receptor 77, ili C5a anafilatoksinski hemotaksni receptor C5L2, je protein koji je kod čoveka kodiran GPR77 genom.[1][2]
Anafilatoksini C3a, C4a, i C5a su katjonski fragmenti formirani tokom kaskade komplementa koja učestvuje u odbrani domaćina. U slučaju neodgovarajuće aktivacije komplementa, anafilatoksini mogu da učestvuju u autoimunosti i sepsi. C5L2 je izražen zajedno sa C5a receptorom (C5R1), na polimorfonuklearnim neutrofilima i može da modulira C5AR aktivnost.[2][3]
Literatura
[уреди | уреди извор]- ^ Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF (2001). „Identification of four novel human G protein-coupled receptors expressed in the brain”. Brain Res Mol Brain Res. 86 (1-2): 13—22. PMID 11165367. doi:10.1016/S0169-328X(00)00242-4.
- ^ а б „Entrez Gene: GPR77 G protein-coupled receptor 77”.
- ^ Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928
. PMID 15489334. doi:10.1101/gr.2596504.
Dodatna literatura
[уреди | уреди извор]- Ohno M; Hirata T; Enomoto M; et al. (2000). „A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells.”. Mol. Immunol. 37 (8): 407—12. PMID 11090875. doi:10.1016/S0161-5890(00)00067-5.
- Cain SA, Monk PN (2002). „The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).”. J. Biol. Chem. 277 (9): 7165—9. PMID 11773063. doi:10.1074/jbc.C100714200.
- Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241
- Kalant D; Cain SA; Maslowska M; et al. (2003). „The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.”. J. Biol. Chem. 278 (13): 11123—9. PMID 12540846. doi:10.1074/jbc.M206169200.
- Otto M; Hawlisch H; Monk PN; et al. (2004). „C5a mutants are potent antagonists of the C5a receptor (CD88) and of C5L2: position 69 is the locus that determines agonism or antagonism.”. J. Biol. Chem. 279 (1): 142—51. PMID 14570896. doi:10.1074/jbc.M310078200.
- Huber-Lang M; Sarma JV; Rittirsch D; et al. (2005). „Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.”. J. Immunol. 174 (2): 1104—10. PMID 15634936.
- Kalant D; MacLaren R; Cui W; et al. (2005). „C5L2 is a functional receptor for acylation-stimulating protein.”. J. Biol. Chem. 280 (25): 23936—44. PMID 15833747. doi:10.1074/jbc.M406921200.
- Johswich K; Martin M; Thalmann J; et al. (2007). „Ligand specificity of the anaphylatoxin C5L2 receptor and its regulation on myeloid and epithelial cell lines.”. J. Biol. Chem. 281 (51): 39088—95. PMID 17068344. doi:10.1074/jbc.M609734200.
- Scola AM; Higginbottom A; Partridge LJ; et al. (2007). „The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding.”. J. Biol. Chem. 282 (6): 3664—71. PMC 2873560
Spoljašnje veze
[уреди | уреди извор]- „Anaphylatoxin Receptors: C5L2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 05. 03. 2012. г.