ZA965798B - Amino-substituted bisphosphonic acids. - Google Patents

Amino-substituted bisphosphonic acids.

Info

Publication number: ZA965798B
Authority: ZA; South Africa
Prior art keywords: amino; bisphosphonic acids; substituted bisphosphonic; substituted; acids
Prior art date: 1995-07-10

Application number

ZA9605798A

Other languages

English (en)

Inventor

E R Van Beek

C W G M Lowick

Socrates Papapoulos

Rafael Labriola

Adriana Vecchioli

Original Assignee

Gador Sa

Univ Leiden

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-10

Filing date

1996-07-09

Publication date

1998-01-09

1996-07-09 Application filed by Gador Sa, Univ Leiden filed Critical Gador Sa

1998-01-09 Publication of ZA965798B publication Critical patent/ZA965798B/xx

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/16—Fluorine compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA9605798A 1995-07-10 1996-07-09 Amino-substituted bisphosphonic acids. ZA965798B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95110706A EP0753523A1 (de)	1995-07-10	1995-07-10	Amino-substuierte bisphosphonsäure

Publications (1)

Publication Number	Publication Date
ZA965798B true ZA965798B (en)	1998-01-09

Family

ID=8219423

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9605798A ZA965798B (en)	1995-07-10	1996-07-09	Amino-substituted bisphosphonic acids.

Country Status (8)

Country	Link
US (1)	US5990098A (de)
EP (2)	EP0753523A1 (de)
JP (1)	JPH11508905A (de)
AR (1)	AR004625A1 (de)
AU (1)	AU6612596A (de)
DE (1)	DE69624707T2 (de)
WO (1)	WO1997002827A1 (de)
ZA (1)	ZA965798B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6660468B1 (en)	1998-10-27	2003-12-09	Board Of Trustees Of The University Of Arkansas	Vitro and in vivo models for screening compounds to prevent glucocorticoid-induced bone destruction
AR013994A1 (es) *	1998-10-30	2001-01-31	Gador Sa	Procedimiento y preparaciones que modulan selectivamente la funcion del osteoblasto para la prevencion y tratamiento de las osteopatias fragilizantes.
AU1525700A (en) *	1998-11-19	2000-06-05	Board Of Trustees Of The University Of Arkansas, The	Increasing bone strength with selected bisphosphonates
ES2369640T3 (es)	2002-05-24	2011-12-02	Angiotech International Ag	Composiciones y métodos para revestir implantes médicos.
EP1644388A2 (de) *	2003-06-27	2006-04-12	ODANI, Akira	Bisphosphonatkomplexe
WO2005090370A1 (en)	2004-02-05	2005-09-29	The Regents Of The University Of California	Pharmacologically active agents containing esterified phosphonates and methods for use thereof
CN1993134A (zh) *	2004-05-19	2007-07-04	默克公司	用于抑制骨吸收含有二膦酸（阿仑膦酸）和维生素d（胆钙化固醇）的组合物
US7068172B2 (en) *	2004-05-21	2006-06-27	Xiao Hui Yang	Method and apparatus for deactivating an EAS device
WO2006110656A2 (en)	2005-04-08	2006-10-19	Chimerix, Inc.	Compounds, compositions and methods for the treatment of viral infections and other medical disorders
EP1868628B1 (de)	2005-04-08	2014-06-11	Chimerix, Inc.	Verbindungen, zusammensetzungen und verfahren zur behandlung von pockenvirus-infektionen
WO2009094190A2 (en)	2008-01-25	2009-07-30	Chimerix, Inc.	Methods of treating viral infections
WO2011011519A1 (en)	2009-07-21	2011-01-27	Chimerix, Inc.	Compounds, compositions and methods for treating ocular conditions
BR112012002551A2 (pt)	2009-08-03	2017-06-13	Chimerix Inc	composição e métodos de tratamento de infecções virais e tumores induzidos por vírus
DK2534150T3 (en)	2010-02-12	2017-06-12	Chimerix Inc	METHODS OF TREATING VIRUS INFECTION
EP2563367A4 (de)	2010-04-26	2013-12-04	Chimerix Inc	Verfahren zur behandlung von retroviren-infektionen und entsprechende dosierungspläne

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1002355C2 (de) *	1954-05-03	1957-07-25	Thomae Gmbh Dr K	Verfahren zur Herstellung von ª‡-prim.-Amino-diphosphonsaeuren und deren Estern
FR8441M (de) *	1968-04-01	1971-07-15
DE2405254C2 (de)	1974-02-04	1982-05-27	Henkel KGaA, 4000 Düsseldorf	Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
AR200473A1 (es)	1974-09-17	1974-11-08	Gador Y Cia Sa Com E Ind Lab	Procedimiento para preparar acidos 1-hidroxialquiliden-difosfonicos y sus sales
GB1508772A (en) *	1975-04-04	1978-04-26	Shell Int Research	Biologically active compositions
DE2534391C2 (de)	1975-08-01	1983-01-13	Henkel KGaA, 4000 Düsseldorf	1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2534390C2 (de) *	1975-08-01	1983-01-13	Henkel KGaA, 4000 Düsseldorf	1,3-Di-aminoalkan-1,1-diphosphonsäuren
AR218558A1 (es)	1979-09-28	1980-06-13	Gador Lab & Cia Sa	Procedimiento para preparar acido 3-amino-1-hidroxi-propilidendifosfonico y sus sales
US4822609A (en) *	1984-12-21	1989-04-18	The Procter & Gamble Company	Treatment of osteoporosis
DE3623397A1 (de) *	1986-07-11	1988-01-14	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4868164A (en)	1986-12-19	1989-09-19	Norwich Eaton Pharmaceuticals, Inc.	Octahydro-pyridine diphosphonate compounds, pharmaceutical compositions, and methods for treating abnormal calcium and phosphate metabolism
US5006329A (en)	1988-01-22	1991-04-09	Cadema Medical Products, Inc.	Radioactive tagged compounds and method for the treatment of metastatic bone cancer
DE3917153A1 (de)	1989-05-26	1990-11-29	Boehringer Mannheim Gmbh	Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5039819A (en)	1990-09-18	1991-08-13	Merck & Co., Inc.	Diphosphonate intermediate for preparing an antihypercalcemic agent
US5103036A (en)	1991-05-13	1992-04-07	E. R. Squibb & Sons, Inc.	Process for preparing 3-alkenylidene-1,1-bisphosphonates
EP0541037A3 (en)	1991-11-06	1997-02-26	Takeda Chemical Industries Ltd	Squalene synthetase inhibitory composition and use thereof
US5205253A (en)	1992-08-24	1993-04-27	Ford Motor Company	Engine operation interrupt using engine operating parameters
FR2703590B1 (fr) *	1993-04-05	1995-06-30	Sanofi Elf	Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .
WO1995028145A1 (en) *	1994-04-18	1995-10-26	The Procter & Gamble Company	Iontophoretic delivery of bisphosphonates to the alveolar bone
WO1996019998A1 (en) *	1994-12-28	1996-07-04	Gador S.A.	Bone mass anabolic composition comprising olpadronate

1995
- 1995-07-10 EP EP95110706A patent/EP0753523A1/de not_active Withdrawn
1996
- 1996-07-08 DE DE69624707T patent/DE69624707T2/de not_active Expired - Lifetime
- 1996-07-08 WO PCT/EP1996/002981 patent/WO1997002827A1/en active IP Right Grant
- 1996-07-08 AU AU66125/96A patent/AU6612596A/en not_active Abandoned
- 1996-07-08 EP EP96925679A patent/EP0837682B1/de not_active Expired - Lifetime
- 1996-07-08 JP JP9505494A patent/JPH11508905A/ja not_active Ceased
- 1996-07-08 AR ARP960103486A patent/AR004625A1/es not_active Application Discontinuation
- 1996-07-08 US US08/983,247 patent/US5990098A/en not_active Expired - Lifetime
- 1996-07-09 ZA ZA9605798A patent/ZA965798B/xx unknown

Also Published As

Publication number	Publication date
US5990098A (en)	1999-11-23
AR004625A1 (es)	1999-03-10
JPH11508905A (ja)	1999-08-03
DE69624707D1 (de)	2002-12-12
EP0753523A1 (de)	1997-01-15
EP0837682B1 (de)	2002-11-06
WO1997002827A1 (en)	1997-01-30
DE69624707T2 (de)	2003-03-20
EP0837682A1 (de)	1998-04-29
AU6612596A (en)	1997-02-10

Publication	Publication Date	Title
ZA967315B (en)	1998-03-02	Biphenylamides.
EP0757411A3 (de)	1997-10-15	Verbinder
MX213417B (es)	2003-03-27	Fenilpiridazinonas.
ZA964468B (en)	1997-02-06	Triazolylmethyl-cyclopentanols.
ZA961955B (en)	1997-09-11	Indazolecarboxamides.
EP0732771A3 (de)	1997-10-22	Steckverbinder
ZA965798B (en)	1998-01-09	Amino-substituted bisphosphonic acids.
DE69610844D1 (en)	2000-12-07	Hydroformylierungsverfahren.
GB2297000B (en)	1999-04-07	Connector
EP0723315A3 (de)	1997-09-24	Verbinder ausgerüstet mit Bolzen
GB9716314D0 (en)	1997-10-08	Connector
ZA966399B (en)	1997-02-19	Endothelin-receptor-antagonists.
GB9512741D0 (en)	1995-08-23	Connector
ZA966750B (en)	1997-02-18	Halogenobenzimidazoles.
ZA966933B (en)	1997-02-19	Endothelin-receptor-antagonists.
ZA967314B (en)	1998-03-02	Carbamoylcarboxamides.
GB9611081D0 (en)	1996-07-31	Connector
GB9515953D0 (en)	1995-10-04	Swept-t connector
GB2301492B (en)	1997-11-26	Flexible-board connector
GB9516577D0 (en)	1995-10-11	Connector
GB2303501B (en)	1999-05-05	Connector
GB9507737D0 (en)	1995-05-31	Timbertech i.g.f. system
IL112479A (en)	2000-01-31	N-amino-1-hydroxyalkylidene-1,1-bisphosphonic acids and their preparation
AU126499S (en)	1996-04-22	Connector
GB9511406D0 (en)	1995-08-02	Connector