ZA958894B - Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them - Google Patents

Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them

Info

Publication number: ZA958894B
Authority: ZA; South Africa
Prior art keywords: alkyl; cycloalkyl; substd; alkoxy; alkenyl
Prior art date: 1994-10-21

Application number

ZA958894A

Other languages

English (en)

Inventor

Daniel Lesieur

Patrick Depreux

Veronique Leclerc

Mansour Hamid Ait

Philippe Delagrange

Pierre Renard

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-21

Filing date

1995-10-20

Publication date

1996-05-14

1995-10-20 Application filed by Adir filed Critical Adir

1996-05-14 Publication of ZA958894B publication Critical patent/ZA958894B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

ZA958894A 1994-10-21 1995-10-20 Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them ZA958894B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9412581A FR2725985B1 (fr)	1994-10-21	1994-10-21	Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA958894B true ZA958894B (en)	1996-05-14

Family

ID=9468074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA958894A ZA958894B (en)	1994-10-21	1995-10-20	Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them

Country Status (17)

Country	Link
US (1)	US5843986A (ja)
EP (1)	EP0708099B1 (ja)
JP (1)	JP2999143B2 (ja)
CN (2)	CN1053662C (ja)
AT (1)	ATE209641T1 (ja)
AU (1)	AU688586B2 (ja)
CA (1)	CA2160961C (ja)
DE (1)	DE69524186T2 (ja)
DK (1)	DK0708099T3 (ja)
ES (1)	ES2169113T3 (ja)
FI (1)	FI118565B (ja)
FR (1)	FR2725985B1 (ja)
HK (1)	HK1029116A1 (ja)
NO (1)	NO314262B1 (ja)
NZ (1)	NZ280298A (ja)
PT (1)	PT708099E (ja)
ZA (1)	ZA958894B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6071946A (en) *	1994-10-21	2000-06-06	Adir Et Compagnie	Tricyclic urea compounds
US5998461A (en) *	1994-10-21	1999-12-07	Adir Et Compagnie	Tricyclic amide compounds
FR2739379B1 (fr) *	1995-09-29	1997-10-24	Adir	Nouveaux composes amines de 5,6,7,8-tetrahydronaphto(2,3-b) furane et d'indano(5,6-b)furane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
US6034239A (en) *	1996-03-08	2000-03-07	Takeda Chemical Industries, Ltd.	Tricyclic compounds, their production and use
CN100443480C (zh) †	1996-03-08	2008-12-17	武田药品工业株式会社	三环化合物及其制备和用途
EP1199304A1 (en) *	1997-03-05	2002-04-24	Takeda Chemical Industries, Ltd.	Bicyclic compounds and pharmaceutical composition containing tricyclic compound for treating or preventing sleep disorders
AU719994B2 (en) *	1996-12-10	2000-05-18	Bristol-Myers Squibb Company	Benzodioxole, benzofuran, dihydrobenzofuran, and benzodioxane melatonergic agents
FR2763335B1 (fr) *	1997-05-16	2000-11-24	Adir	Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2772766B1 (fr) *	1997-12-24	2000-06-30	Adir	Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2773798B1 (fr) *	1998-01-16	2001-02-02	Adir	Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1082115A4 (en)	1998-06-05	2002-10-24	Bristol Myers Squibb Co	MELATONERGICS BASED ON HETEROCYCLIC CIS DERIVATIVES OF CYCLOPROPANE
DE60007745T2 (de)	1999-06-30	2005-03-10	Bristol-Myers Squibb Co.	Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe
DE60019619T2 (de)	1999-08-20	2006-03-02	Takeda Chemical Industries, Ltd.	Dihydrobenzofuranderivate, verfahren zu ihrer herstellung und mittel
FR2805993B1 (fr) *	2000-03-08	2004-01-16	Adir	Utilisation de ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention ou au traitement du developpement de la tolerance aux composes nitres
US7012090B1 (en)	2000-03-17	2006-03-14	Alcon, Inc.	Pyranoindoles for treating glaucoma
TWI402261B (zh) *	2006-06-19	2013-07-21	Takeda Pharmaceutical	三環化合物及其醫藥組成物
CA2671354A1 (en) *	2006-12-08	2008-06-12	Takeda Pharmaceutical Company Limited	Tricyclic compound and medical use thereof
GB201002372D0 (en)	2010-02-12	2010-03-31	Element Six Production Pty Ltd	A superhard multiphase material and method of using same
CN107325011A (zh) *	2016-04-30	2017-11-07	陕西合成药业股份有限公司	一种褪黑激素类化合物及其制备方法和用途
MX2023014819A (es)	2021-06-14	2024-03-21	Scorpion Therapeutics Inc	Derivados de la urea que pueden ser utilizados para tratar el cancer.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2613365B1 (fr) *	1987-04-01	1989-07-28	Adir	Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613364B1 (fr) *	1987-04-01	1989-06-09	Adir	Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680507B1 (fr) *	1991-08-23	1993-10-08	Adir Cie	Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2689124A1 (fr) *	1992-03-27	1993-10-01	Adir	Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9407919D0 (en) *	1994-04-21	1994-06-15	Glaxo Group Ltd	Chemical compounds

1994
- 1994-10-21 FR FR9412581A patent/FR2725985B1/fr not_active Expired - Fee Related
1995
- 1995-10-18 NO NO19954149A patent/NO314262B1/no not_active IP Right Cessation
- 1995-10-19 EP EP95402331A patent/EP0708099B1/fr not_active Expired - Lifetime
- 1995-10-19 ES ES95402331T patent/ES2169113T3/es not_active Expired - Lifetime
- 1995-10-19 US US08/545,395 patent/US5843986A/en not_active Expired - Fee Related
- 1995-10-19 AT AT95402331T patent/ATE209641T1/de not_active IP Right Cessation
- 1995-10-19 DE DE69524186T patent/DE69524186T2/de not_active Expired - Fee Related
- 1995-10-19 PT PT95402331T patent/PT708099E/pt unknown
- 1995-10-19 CA CA002160961A patent/CA2160961C/fr not_active Expired - Fee Related
- 1995-10-19 DK DK95402331T patent/DK0708099T3/da active
- 1995-10-20 ZA ZA958894A patent/ZA958894B/xx unknown
- 1995-10-20 NZ NZ280298A patent/NZ280298A/en not_active IP Right Cessation
- 1995-10-20 AU AU34377/95A patent/AU688586B2/en not_active Ceased
- 1995-10-20 JP JP7272750A patent/JP2999143B2/ja not_active Expired - Fee Related
- 1995-10-20 CN CN95115980A patent/CN1053662C/zh not_active Expired - Fee Related
- 1995-10-20 FI FI955023A patent/FI118565B/fi active IP Right Grant
1999
- 1999-12-15 CN CNB991261585A patent/CN1137889C/zh not_active Expired - Fee Related
2000
- 2000-12-28 HK HK00108449A patent/HK1029116A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT708099E (pt)	2002-05-31
ATE209641T1 (de)	2001-12-15
NO954149L (no)	1996-04-22
JP2999143B2 (ja)	2000-01-17
NO314262B1 (no)	2003-02-24
DE69524186D1 (de)	2002-01-10
HK1029116A1 (en)	2001-03-23
ES2169113T3 (es)	2002-07-01
FI955023A0 (fi)	1995-10-20
JPH08239377A (ja)	1996-09-17
CN1263095A (zh)	2000-08-16
NZ280298A (en)	1996-10-28
CN1053662C (zh)	2000-06-21
AU688586B2 (en)	1998-03-12
EP0708099A1 (fr)	1996-04-24
EP0708099B1 (fr)	2001-11-28
FR2725985A1 (fr)	1996-04-26
CA2160961C (fr)	2001-07-17
CN1137889C (zh)	2004-02-11
AU3437795A (en)	1996-05-02
DE69524186T2 (de)	2002-07-04
CN1130184A (zh)	1996-09-04
FI955023A (fi)	1996-04-22
CA2160961A1 (fr)	1996-04-22
NO954149D0 (no)	1995-10-18
FR2725985B1 (fr)	1996-11-15
US5843986A (en)	1998-12-01
FI118565B (fi)	2007-12-31
DK0708099T3 (da)	2002-02-11

Publication	Publication Date	Title
AU688586B2 (en)	1998-03-12	New tricyclic amide compounds, processes for their preparation and the pharmaceutical compositions which contain them
ES2034893A1 (es)	1993-04-01	Procedimiento para la obtencion de nuevos pregna-1,4-diene-3,20-dione-16-17-acetal-21 esteres.
EP0422596A3 (en)	1992-03-11	Tricyclic carbapenem compounds
CA2275166A1 (en)	1998-06-18	Novel benzopyran derivatives
AU660469B2 (en)	1995-06-29	Pharmacologically active hydrazine derivatives and processes for the preparation thereof
GR3032289T3 (en)	2000-04-27	Alkoxy aryl compounds with affinity to the melatonine receptors, process for their preparation and pharmaceutical compositions containing them
HU9802757D0 (en)	1999-01-28	New naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them
AU4872793A (en)	1994-04-14	New ellipticine compounds, a process for their preparation and pharmaceutical compositions containing them
EP0669336A4 (en)	1996-04-10	NEW CEPHEM DERIVATIVES.
HU9400094D0 (en)	1994-05-30	New 17,20-epoxy-pregnane derivatives process for producing them and use of them for producing cortizone derivatives and intermadeiates
ATE135694T1 (de)	1996-04-15	Alkylthiopoly(ethylimidazolium)verbindungen, verfahren zur herstellung und deren verwendung als biozidemittel
DK0955286T3 (da)	2002-11-25	Dihydro- eller tetrahydronaphthalenderivater med (anti) østrogen virkning
BG100887A (en)	1998-01-30	Process for the preparation of 7-hydroxy taxanes
TW198031B (ja)	1993-01-11
ES2128572T3 (es)	1999-05-16	Utilizacion de los derivados de cefem como agentes antimetastaticos.
ES8101646A1 (es)	1980-12-16	Un procedimiento para producir un compuesto opticamente ac- tivo
CA2027542A1 (en)	1990-08-24	Uv-absorbing cyclic enaminoketones
PT90831A (pt)	1989-12-29	Processo para a preparacao de eteres da 2-amino-7-hidroxitetralina
ATE52501T1 (de)	1990-05-15	Cyclohexan-1,3-dionderivate, diese enthaltende zusammensetzungen, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren.