ZA954940B - Enzyme inhibitors - Google Patents

Enzyme inhibitors

Info

Publication number: ZA954940B
Authority: ZA; South Africa
Prior art keywords: enzyme inhibitors; protecting group; amidino; intermediates; chem
Prior art date: 1994-06-15

Application number

ZA954940A

Other languages

English (en)

Inventor

Harold Francis Hodson

David Alan Sawyer

Karl Witold Franzmann

Steven Smith

Helen Alice Rebecca Clark

Richard Michael John Palmer

Richard Graham Knowles

Martin James Drysdale

Patricia Ifeyinwa Davies

Barry George Shearer

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-15

Filing date

1995-06-14

Publication date

1996-12-17

1995-05-15 Priority claimed from GBGB9509774.7A external-priority patent/GB9509774D0/en

1995-06-14 Application filed by Wellcome Found filed Critical Wellcome Found

1996-12-17 Publication of ZA954940B publication Critical patent/ZA954940B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Hydrogenated Pyridines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Steroid Compounds (AREA)

ZA954940A 1994-06-15 1995-06-14 Enzyme inhibitors ZA954940B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94304314		1994-06-15
GBGB9509774.7A GB9509774D0 (en)	1995-05-15	1995-05-15	Enzyme inhibitors

Publications (1)

Publication Number	Publication Date
ZA954940B true ZA954940B (en)	1996-12-17

Family

ID=26137155

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA954940A ZA954940B (en)	1994-06-15	1995-06-14	Enzyme inhibitors

Country Status (29)

Country	Link
US (2)	US5889056A (ru)
EP (2)	EP0957087B1 (ru)
JP (2)	JP2989010B2 (ru)
KR (1)	KR100430207B1 (ru)
CN (1)	CN1070849C (ru)
AT (2)	ATE229001T1 (ru)
AU (1)	AU692892B2 (ru)
BR (1)	BR9507995A (ru)
CA (1)	CA2192668A1 (ru)
CY (2)	CY2238B1 (ru)
DE (2)	DE69516141T2 (ru)
DK (2)	DK0765308T3 (ru)
ES (2)	ES2189322T3 (ru)
FI (1)	FI965019A (ru)
GR (1)	GR3033746T3 (ru)
HK (1)	HK1003935A1 (ru)
HU (1)	HUT77407A (ru)
IL (2)	IL114142A (ru)
IS (1)	IS4384A (ru)
MX (1)	MX9606136A (ru)
MY (1)	MY115437A (ru)
NO (1)	NO308655B1 (ru)
NZ (1)	NZ289157A (ru)
PT (2)	PT957087E (ru)
RU (1)	RU2162841C2 (ru)
SI (2)	SI0765308T1 (ru)
TW (1)	TW442453B (ru)
WO (1)	WO1995034534A1 (ru)
ZA (1)	ZA954940B (ru)

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DE10111050A1 (de) *	2001-03-06	2002-09-12	Beiersdorf Ag	Verwendung von Substanzen, die verhindern, daß die NO-Synthase des warmblütigenOrganismus ihre Wirkung entfaltet, zur Herstellung von kosmetischewn oder dermatologischen Zubereitungen zur Behandlung und/oder Prophylaxe unerwünschter Hautpigmentierung
DE10111054A1 (de) *	2001-03-06	2002-09-12	Beiersdorf Ag	Verwendung von Substanzen, die verhindern, daß die NO-Synthese des warmblütigen Organismus ihre Wirkung entfaltet, zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Stärkung der Barrierefunktion der Haut
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PL2046787T3 (pl)	2006-08-01	2011-10-31	Glaxo Group Ltd	Związki pirazolo[3,4-b]pirydynowe i ich zastosowanie jako inhibitory PDE4
AU2007354255A1 (en) *	2006-11-09	2008-12-04	University Of Maryland, Baltimore	Use of 5,6-dimethylxanthenone-4-acetic acid as an antimicrobial agent
PE20081889A1 (es)	2007-03-23	2009-03-05	Smithkline Beecham Corp	Indol carboxamidas como inhibidores de ikk2
US20110160249A1 (en)	2008-05-23	2011-06-30	Schaab Kevin Murray	5-lipoxygenase-activating protein inhibitor
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1995
- 1995-06-14 AT AT99116304T patent/ATE229001T1/de not_active IP Right Cessation
- 1995-06-14 DE DE69516141T patent/DE69516141T2/de not_active Expired - Fee Related
- 1995-06-14 ES ES99116304T patent/ES2189322T3/es not_active Expired - Lifetime
- 1995-06-14 EP EP99116304A patent/EP0957087B1/en not_active Expired - Lifetime
- 1995-06-14 NZ NZ289157A patent/NZ289157A/en not_active IP Right Cessation
- 1995-06-14 SI SI9530412T patent/SI0765308T1/xx unknown
- 1995-06-14 CA CA002192668A patent/CA2192668A1/en not_active Abandoned
- 1995-06-14 DK DK95924405T patent/DK0765308T3/da active
- 1995-06-14 DK DK99116304T patent/DK0957087T3/da active
- 1995-06-14 RU RU97100747/04A patent/RU2162841C2/ru not_active IP Right Cessation
- 1995-06-14 BR BR9507995A patent/BR9507995A/pt not_active IP Right Cessation
- 1995-06-14 AU AU28917/95A patent/AU692892B2/en not_active Ceased
- 1995-06-14 WO PCT/GB1995/001378 patent/WO1995034534A1/en active IP Right Grant
- 1995-06-14 US US08/750,679 patent/US5889056A/en not_active Ceased
- 1995-06-14 PT PT99116304T patent/PT957087E/pt unknown
- 1995-06-14 KR KR1019960707192A patent/KR100430207B1/ko not_active IP Right Cessation
- 1995-06-14 HU HU9603454A patent/HUT77407A/hu unknown
- 1995-06-14 US US10/407,204 patent/USRE39576E1/en not_active Expired - Lifetime
- 1995-06-14 EP EP95924405A patent/EP0765308B1/en not_active Expired - Lifetime
- 1995-06-14 ES ES95924405T patent/ES2145282T3/es not_active Expired - Lifetime
- 1995-06-14 CN CN95194518A patent/CN1070849C/zh not_active Expired - Fee Related
- 1995-06-14 SI SI9530645T patent/SI0957087T1/xx unknown
- 1995-06-14 JP JP8501803A patent/JP2989010B2/ja not_active Expired - Lifetime
- 1995-06-14 AT AT95924405T patent/ATE191470T1/de not_active IP Right Cessation
- 1995-06-14 DE DE69529101T patent/DE69529101T2/de not_active Expired - Lifetime
- 1995-06-14 ZA ZA954940A patent/ZA954940B/xx unknown
- 1995-06-14 IL IL11414295A patent/IL114142A/xx not_active IP Right Cessation
- 1995-06-14 PT PT95924405T patent/PT765308E/pt unknown
- 1995-06-15 MY MYPI95001621A patent/MY115437A/en unknown
- 1995-07-15 TW TW084107349A patent/TW442453B/zh not_active IP Right Cessation
1996
- 1996-11-13 IS IS4384A patent/IS4384A/is unknown
- 1996-12-05 MX MX9606136A patent/MX9606136A/es not_active IP Right Cessation
- 1996-12-13 NO NO965379A patent/NO308655B1/no unknown
- 1996-12-13 FI FI965019A patent/FI965019A/fi not_active Application Discontinuation
1998
- 1998-04-17 HK HK98103253A patent/HK1003935A1/xx not_active IP Right Cessation
1999
- 1999-02-25 IL IL12871799A patent/IL128717A0/xx not_active IP Right Cessation
- 1999-06-07 JP JP16019399A patent/JP3614711B2/ja not_active Expired - Fee Related
2000
- 2000-06-22 GR GR20000401441T patent/GR3033746T3/el not_active IP Right Cessation
2001
- 2001-09-07 CY CY0100026A patent/CY2238B1/xx unknown
2004
- 2004-06-03 CY CY0400042A patent/CY2455B1/xx unknown

Also Published As

Publication number	Publication date
CY2238B1 (en)	2003-07-04
WO1995034534A1 (en)	1995-12-21
AU692892B2 (en)	1998-06-18
EP0957087A2 (en)	1999-11-17
EP0765308A1 (en)	1997-04-02
IL114142A0 (en)	1995-10-31
CA2192668A1 (en)	1995-12-21
HUT77407A (hu)	1998-04-28
PT765308E (pt)	2000-09-29
FI965019A0 (fi)	1996-12-13
ES2145282T3 (es)	2000-07-01
IL114142A (en)	2000-02-17
CY2455B1 (en)	2005-06-03
HU9603454D0 (en)	1997-02-28
TW442453B (en)	2001-06-23
DE69516141T2 (de)	2000-10-19
DE69516141D1 (de)	2000-05-11
CN1070849C (zh)	2001-09-12
USRE39576E1 (en)	2007-04-17
US5889056A (en)	1999-03-30
ATE229001T1 (de)	2002-12-15
RU2162841C2 (ru)	2001-02-10
DE69529101D1 (de)	2003-01-16
DK0957087T3 (da)	2003-03-24
JPH10506371A (ja)	1998-06-23
JP2989010B2 (ja)	1999-12-13
CN1155276A (zh)	1997-07-23
MX9606136A (es)	1998-06-30
EP0957087A3 (en)	2000-12-20
PT957087E (pt)	2003-04-30
EP0765308B1 (en)	2000-04-05
IL128717A0 (en)	2000-01-31
HK1003935A1 (en)	1998-11-13
MY115437A (en)	2003-06-30
NO965379D0 (no)	1996-12-13
DE69529101T2 (de)	2003-11-13
ATE191470T1 (de)	2000-04-15
NO965379L (no)	1996-12-13
DK0765308T3 (da)	2000-09-11
NZ289157A (en)	1998-03-25
ES2189322T3 (es)	2003-07-01
JP3614711B2 (ja)	2005-01-26
IS4384A (is)	1996-11-13
NO308655B1 (no)	2000-10-09
KR100430207B1 (ko)	2004-07-19
EP0957087B1 (en)	2002-12-04
JP2000026402A (ja)	2000-01-25
FI965019A (fi)	1996-12-13
BR9507995A (pt)	1997-08-05
AU2891795A (en)	1996-01-05
SI0765308T1 (en)	2000-08-31
SI0957087T1 (en)	2003-04-30
GR3033746T3 (en)	2000-10-31

Publication	Publication Date	Title
CY2238B1 (en)	2003-07-04	Enzyme inhibitors
ATE177078T1 (de)	1999-03-15	Amidino-derivate als no-synthetase inhibitoren
AU6645998A (en)	1998-07-17	Oxygen or sulfur containing heteroaromatics as factor xa inhibitors
AU3367995A (en)	1996-03-14	New multimerizing agents
MX9701088A (es)	1997-08-30	Composicion de recubrimiento inhibidora de corrosion para metales.
IL135536A0 (en)	2001-05-20	Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same
CA2263566A1 (en)	1998-03-05	Substituted 6,5-hetero-bicyclic derivatives
WO2003006425A3 (en)	2003-11-27	Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
CA2203237A1 (en)	1996-05-23	Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
DE60228316D1 (en)	2008-09-25	Xanthinoxidaseinhibitoren
IL123805A0 (en)	1998-10-30	Use of hydroximic acid derivatives for the protection of mitochondrial genome
MY128323A (en)	2007-01-31	Thiazole derivatives for inhibition of cytokine production and of cell adhesion
CA2214601A1 (en)	1996-10-03	Mercapto and seleno derivatives as inhibitors of nitric oxide synthase
IL111791A0 (en)	1995-01-24	Glutaramide derivatives
BG103520A (en)	2000-06-30	The use of aminothiazoles as microbicides
AP9400608A0 (en)	1995-07-12	"New nicotinic acid derivative".
IE890257L (en)	1989-07-29	Hydrazides and hydroxamic acid derivatives
CA2177586A1 (en)	1995-06-22	4-benzoylisoxazoles and their use as herbicides
MX9604347A (es)	1998-05-31	Derivados del acido 2-(4-pirazoliloxi-pirimidin-5-il) acetico.