ZA933461B - Dual action inhibitors - Google Patents

Dual action inhibitors

Info

Publication number: ZA933461B
Authority: ZA; South Africa
Prior art keywords: dual action; action inhibitors; compounds; disclosed; inhibitors
Prior art date: 1992-05-18

Application number

ZA933461A

Other languages

English (en)

Inventor

Donald S Karanewsky

Joel C Barrish

Edward W Petrillo Jr

Jeffrey A Robl

Denis E Ryono

Original Assignee

Squibb & Sons Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-05-18

Filing date

1993-05-18

Publication date

1993-12-14

1993-05-18 Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc

1993-12-14 Publication of ZA933461B publication Critical patent/ZA933461B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA933461A 1992-05-18 1993-05-18 Dual action inhibitors ZA933461B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US88466492A	1992-05-18	1992-05-18

Publications (1)

Publication Number	Publication Date
ZA933461B true ZA933461B (en)	1993-12-14

Family

ID=25385092

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA933461A ZA933461B (en)	1992-05-18	1993-05-18	Dual action inhibitors

Country Status (28)

Country	Link
EP (2)	EP0599444B1 (de)
JP (1)	JP3487611B2 (de)
KR (2)	KR100288722B1 (de)
CN (1)	CN1039008C (de)
AT (1)	ATE162800T1 (de)
AU (2)	AU659550B2 (de)
BR (1)	BR1101081A (de)
CA (1)	CA2096460C (de)
CY (1)	CY2093B1 (de)
CZ (1)	CZ289824B6 (de)
DE (1)	DE69316717T2 (de)
DK (1)	DK0599444T3 (de)
ES (1)	ES2111712T3 (de)
FI (1)	FI103337B1 (de)
GR (1)	GR3026665T3 (de)
HK (1)	HK1003597A1 (de)
HU (1)	HU217078B (de)
IL (1)	IL105729A (de)
MX (1)	MX9302876A (de)
MY (1)	MY111370A (de)
NO (1)	NO304372B1 (de)
NZ (1)	NZ247642A (de)
PL (1)	PL173036B1 (de)
RU (1)	RU2124503C1 (de)
SG (1)	SG54138A1 (de)
SK (1)	SK283556B6 (de)
TW (1)	TW290544B (de)
ZA (1)	ZA933461B (de)

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1993
- 1993-05-17 RU RU93036185/04A patent/RU2124503C1/ru not_active IP Right Cessation
- 1993-05-18 DE DE69316717T patent/DE69316717T2/de not_active Expired - Fee Related
- 1993-05-18 EP EP93303835A patent/EP0599444B1/de not_active Expired - Lifetime
- 1993-05-18 NZ NZ247642A patent/NZ247642A/xx unknown
- 1993-05-18 MX MX9302876A patent/MX9302876A/es not_active IP Right Cessation
- 1993-05-18 CA CA002096460A patent/CA2096460C/en not_active Expired - Fee Related
- 1993-05-18 MY MYPI93000910A patent/MY111370A/en unknown
- 1993-05-18 AU AU38627/93A patent/AU659550B2/en not_active Ceased
- 1993-05-18 JP JP11587493A patent/JP3487611B2/ja not_active Expired - Fee Related
- 1993-05-18 EP EP97200315A patent/EP0783002A3/de not_active Withdrawn
- 1993-05-18 ES ES93303835T patent/ES2111712T3/es not_active Expired - Lifetime
- 1993-05-18 KR KR1019930008448A patent/KR100288722B1/ko not_active IP Right Cessation
- 1993-05-18 FI FI932249A patent/FI103337B1/fi active
- 1993-05-18 CZ CZ1993936A patent/CZ289824B6/cs not_active IP Right Cessation
- 1993-05-18 NO NO931795A patent/NO304372B1/no not_active IP Right Cessation
- 1993-05-18 CN CN93107593A patent/CN1039008C/zh not_active Expired - Fee Related
- 1993-05-18 SK SK499-93A patent/SK283556B6/sk unknown
- 1993-05-18 HU HU9301448A patent/HU217078B/hu not_active IP Right Cessation
- 1993-05-18 SG SG1996001951A patent/SG54138A1/en unknown
- 1993-05-18 DK DK93303835T patent/DK0599444T3/da active
- 1993-05-18 AT AT93303835T patent/ATE162800T1/de not_active IP Right Cessation
- 1993-05-18 PL PL93298988A patent/PL173036B1/pl not_active IP Right Cessation
- 1993-05-18 ZA ZA933461A patent/ZA933461B/xx unknown
- 1993-05-18 IL IL105729A patent/IL105729A/en not_active IP Right Cessation
- 1993-05-19 TW TW082103946A patent/TW290544B/zh active
1995
- 1995-08-14 AU AU28525/95A patent/AU674629B2/en not_active Ceased
1997
- 1997-05-14 BR BR1101081-9A patent/BR1101081A/pt active IP Right Grant
1998
- 1998-03-27 HK HK98102619A patent/HK1003597A1/xx not_active IP Right Cessation
- 1998-04-15 GR GR980400870T patent/GR3026665T3/el unknown
- 1998-07-01 CY CY9800015A patent/CY2093B1/xx unknown
2000
- 2000-04-28 KR KR1020000022662A patent/KR100277453B1/ko not_active IP Right Cessation

Also Published As

Publication number	Publication date
CZ93693A3 (en)	1993-12-15
EP0783002A2 (de)	1997-07-09
CA2096460A1 (en)	1993-11-19
FI932249A0 (fi)	1993-05-18
SK283556B6 (sk)	2003-09-11
HU217078B (hu)	1999-11-29
AU659550B2 (en)	1995-05-18
SG54138A1 (en)	1998-11-16
FI932249A (fi)	1993-11-19
FI103337B (fi)	1999-06-15
SK49993A3 (en)	1994-08-10
TW290544B (de)	1996-11-11
GR3026665T3 (en)	1998-07-31
CN1039008C (zh)	1998-07-08
NO304372B1 (no)	1998-12-07
CZ289824B6 (cs)	2002-04-17
AU674629B2 (en)	1997-01-02
EP0599444B1 (de)	1998-01-28
ES2111712T3 (es)	1998-03-16
AU3862793A (en)	1993-11-25
DE69316717T2 (de)	1998-08-27
JPH0656790A (ja)	1994-03-01
AU2852595A (en)	1995-10-19
CY2093B1 (en)	2002-04-05
KR100277453B1 (ko)	2000-12-15
MX9302876A (es)	1993-12-01
FI103337B1 (fi)	1999-06-15
DE69316717D1 (de)	1998-03-05
MY111370A (en)	1999-12-31
RU2124503C1 (ru)	1999-01-10
PL173036B1 (pl)	1998-01-30
IL105729A0 (en)	1993-09-22
HU9301448D0 (en)	1993-09-28
HK1003597A1 (en)	1998-10-30
HUT68391A (en)	1995-06-28
CA2096460C (en)	2004-03-16
JP3487611B2 (ja)	2004-01-19
KR930023349A (ko)	1993-12-18
KR100288722B1 (ko)	2001-05-02
NO931795D0 (no)	1993-05-18
ATE162800T1 (de)	1998-02-15
BR1101081A (pt)	2000-03-28
EP0783002A3 (de)	1997-07-30
PL298988A1 (en)	1994-01-24
CN1084849A (zh)	1994-04-06
NZ247642A (en)	1995-09-26
IL105729A (en)	1998-01-04
EP0599444A1 (de)	1994-06-01
NO931795L (no)	1993-11-19
DK0599444T3 (da)	1998-09-21

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HK1003597A1 (en)	1998-10-30	Dual action inhibitors
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PL319605A1 (en)	1997-08-18	Novel benzoxazoles
IE810474L (en)	1981-09-05	Anti-hypertensive agents
PT81308A (en)	1985-11-01	Process for preparing a combination of dihydropyridines with ace(angiotensin converting enzymes) inhibitors useful as medicament
EP0310072A3 (de)	1989-11-29	Nichtpeptide beta-Succinamidoacylaminodiole als antihypertensive Agenzien
EP0310070A3 (de)	1989-11-29	Alpha-aminoacyl-beta-aminoacyl-Aminodiole als anti-hypertensive Agenzien
EP0313847A3 (de)	1989-11-29	Nichtpeptide alpha-succinamidoacyl-Aminodiole als antihypertensive Agenzien
MX9500228A (es)	1997-02-28	N-oxidos de 4-arilpiperazinas y 4-arilpiperidinas.
IL121352A0 (en)	1998-01-04	Intermediates for the preparation of 2-imidazolin-5-ones
MA21068A1 (fr)	1988-04-01	Procede de preparation d'une composition a base d'inhibiteur de l'enzyme de conversion de l'angiotensine .
EP0297816A3 (en)	1990-09-05	Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
IL97696A0 (en)	1992-06-21	Haloethyl-substituted steroidal enzyme inhibitors