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ZA200904501B - 1H-benzimidazole-4-carboxamides substituted with a quarternary carbon at the 2-position are potent parp inhibitors - Google Patents

1H-benzimidazole-4-carboxamides substituted with a quarternary carbon at the 2-position are potent parp inhibitors

Info

Publication number
ZA200904501B
ZA200904501B ZA200904501A ZA200904501A ZA200904501B ZA 200904501 B ZA200904501 B ZA 200904501B ZA 200904501 A ZA200904501 A ZA 200904501A ZA 200904501 A ZA200904501 A ZA 200904501A ZA 200904501 B ZA200904501 B ZA 200904501B
Authority
ZA
South Africa
Prior art keywords
benzimidazole
parp inhibitors
potent parp
quarternary carbon
carboxamides substituted
Prior art date
Application number
ZA200904501A
Other languages
English (en)
Inventor
Guidong Zhu
Jianchun Gong
Virajkumar B Gandhi
Thomas D Penning
Vincent Giranda
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ZA200904501B publication Critical patent/ZA200904501B/xx

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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ZA200904501A 2005-04-11 2009-06-26 1H-benzimidazole-4-carboxamides substituted with a quarternary carbon at the 2-position are potent parp inhibitors ZA200904501B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67020405P 2005-04-11 2005-04-11

Publications (1)

Publication Number Publication Date
ZA200904501B true ZA200904501B (en) 2010-05-26

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ZA200904501A ZA200904501B (en) 2005-04-11 2009-06-26 1H-benzimidazole-4-carboxamides substituted with a quarternary carbon at the 2-position are potent parp inhibitors

Country Status (24)

Country Link
US (1) US7550603B2 (pt)
EP (3) EP1869011B1 (pt)
JP (1) JP4960342B2 (pt)
KR (1) KR101349206B1 (pt)
CN (2) CN104961723A (pt)
AU (1) AU2006235492B2 (pt)
BR (1) BRPI0609121B8 (pt)
CA (1) CA2603784C (pt)
CY (1) CY1123919T1 (pt)
DK (2) DK1869011T3 (pt)
ES (2) ES2426981T3 (pt)
HK (3) HK1119168A1 (pt)
HR (2) HRP20120819T1 (pt)
IL (2) IL186303A (pt)
ME (2) ME02087B (pt)
MX (1) MX2007012593A (pt)
NZ (1) NZ561729A (pt)
PL (2) PL1869011T3 (pt)
PT (2) PT2420234E (pt)
RS (2) RS52990B (pt)
SI (1) SI2420234T1 (pt)
TW (1) TWI375673B (pt)
WO (1) WO2006110816A2 (pt)
ZA (1) ZA200904501B (pt)

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