ZA200501381B - New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors - Google Patents

New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

Info

Publication number: ZA200501381B
Authority: ZA; South Africa
Prior art keywords: spirocondensed; quinazolinones; new; phosphodiesterase inhibitors; phosphodiesterase
Prior art date: 2002-09-17

Application number

ZA200501381A

Other languages

English (en)

Inventor

Bernardelli Patrick

Vergne Fabrice

Mendes Chrystelle

Ducrot Pierre Gurard

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-17

Filing date

2005-02-16

Publication date

2006-11-29

2005-02-16 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2006-11-29 Publication of ZA200501381B publication Critical patent/ZA200501381B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Diabetes (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Hematology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Ophthalmology & Optometry (AREA)
Transplantation (AREA)
Dermatology (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)

ZA200501381A 2002-09-17 2005-02-16 New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors ZA200501381B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP20020292275 EP1400244A1 (en)	2002-09-17	2002-09-17	New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

Publications (1)

Publication Number	Publication Date
ZA200501381B true ZA200501381B (en)	2006-11-29

Family

ID=31896987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200501381A ZA200501381B (en)	2002-09-17	2005-02-16	New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors

Country Status (30)

Country	Link
US (1)	US7429598B2 (es)
EP (2)	EP1400244A1 (es)
JP (1)	JP2006501277A (es)
KR (1)	KR20050057371A (es)
CN (1)	CN1681507A (es)
AP (1)	AP2005003251A0 (es)
AR (1)	AR041271A1 (es)
AU (1)	AU2003259496A1 (es)
BR (1)	BR0314379A (es)
CA (1)	CA2499330C (es)
CO (1)	CO5540391A2 (es)
CR (1)	CR7728A (es)
EA (1)	EA200500312A1 (es)
EC (1)	ECSP055671A (es)
GT (1)	GT200300201A (es)
HN (1)	HN2003000285A (es)
HR (1)	HRP20050223A2 (es)
IS (1)	IS7700A (es)
MA (1)	MA27439A1 (es)
MX (1)	MXPA05002913A (es)
NO (1)	NO20051695L (es)
OA (1)	OA12924A (es)
PA (1)	PA8582801A1 (es)
PE (1)	PE20050073A1 (es)
PL (1)	PL375977A1 (es)
TN (1)	TNSN05073A1 (es)
TW (1)	TWI251590B (es)
UY (1)	UY27986A1 (es)
WO (1)	WO2004026818A1 (es)
ZA (1)	ZA200501381B (es)

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JP4718172B2 (ja)	2002-06-12	2011-07-06	シンフォニーエボルーション，インク．	ヒトａｄａｍ−１０インヒビター
WO2006092691A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of pde7 inhibitors for the treatment of neuropathic pain
GB0504209D0 (en) *	2005-03-01	2005-04-06	Pfizer Ltd	New use of PDE7 inhibitors
WO2006092692A1 (en) *	2005-03-01	2006-09-08	Pfizer Limited	Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
EP1928437A2 (en)	2005-08-26	2008-06-11	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
JP2009517453A (ja)	2005-12-02	2009-04-30	ファイザー・リミテッド	Ｐｄｅ７阻害剤としてのスピロ環式キナゾリン誘導体
EP2460793A1 (en)	2006-02-03	2012-06-06	Bionomics Limited	Substituted Benzofurans, Benzothiophenes, Benzoselenophenes and Indoles And Their Use as Tubulin Polymerisation Inhibitors
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US7678808B2 (en)	2006-05-09	2010-03-16	Braincells, Inc.	5 HT receptor mediated neurogenesis
EP2377531A2 (en)	2006-05-09	2011-10-19	Braincells, Inc.	Neurogenesis by modulating angiotensin
MX2009002496A (es)	2006-09-08	2009-07-10	Braincells Inc	Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
CN101917992A (zh) *	2007-03-27	2010-12-15	奥默罗斯公司	用于治疗运动障碍的pde7抑制剂的用途
US8637528B2 (en)	2007-03-27	2014-01-28	Omeros Corporation	Use of PDE7 inhibitors for the treatment of movement disorders
CA2687944A1 (en) *	2007-05-24	2008-11-27	Pfizer Limited	Spirocyclic quinazoline derivatives and their use as pde7 inhibitors
NZ582349A (en) *	2007-06-29	2012-06-29	Sunesis Pharmaceuticals Inc	Heterocyclic compounds useful as raf kinase inhibitors
AR067354A1 (es)	2007-06-29	2009-10-07	Sunesis Pharmaceuticals Inc	Compuestos utiles como inhibidores de la raf quinasa
SG10201809895YA (en) *	2008-08-06	2018-12-28	Medivation Tech Llc	Dihydropyridophthalazinone inhibitors of poly(adp-ribose)polymerase (parp)
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
EP2531033A4 (en)	2010-02-03	2013-07-31	Biomarin Pharm Inc	POLY (ADP-RIBOSE) POLYMERASE (PARP) DIHYDROPYRIDOPHTHALAZINE HEMMER FOR USE IN THE TREATMENT OF PTEN-LACK ASSOCIATED DISEASES
US20110190266A1 (en) *	2010-02-04	2011-08-04	Daniel Chu	5,6,6a,7,8,9-HEXAHYDRO-2H-PYRIDOPHTHALAZINONE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP)
HUE030794T2 (en)	2010-02-08	2017-06-28	Medivation Technologies Inc	Synthesis Processes of Dihydro-Pyrido-Phthalazinone Derivatives
CN103282365B (zh)	2010-10-21	2017-12-29	麦迪韦逊科技有限公司	结晶的(8S,9R)‑5‑氟‑8‑(4‑氟苯基)‑9‑(1‑甲基‑1H‑1,2,4‑三唑‑5‑基)‑8,9‑二氢‑2H‑吡啶并[4,3,2‑de]酞嗪‑3(7H)‑酮甲苯磺酸盐
CN107375296A (zh)	2010-11-08	2017-11-24	奥默罗斯公司	使用pde7抑制剂治疗成瘾和冲动控制障碍
US9220715B2 (en)	2010-11-08	2015-12-29	Omeros Corporation	Treatment of addiction and impulse-control disorders using PDE7 inhibitors
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
MX2020000295A (es)	2017-07-12	2020-07-22	Dart Neuroscience Llc	Compuestos de benzoxazol y benzofurano sustituidos como inhibidores de pde7.
CN112574202B (zh) *	2020-12-11	2021-11-09	台州学院	一种螺喹唑啉-2-酮类衍生物及其制备方法和应用
WO2024038089A1 (en)	2022-08-18	2024-02-22	Mitodicure Gmbh	Use of a therapeutic agent with phosphodiesterase-7 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

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JPS5959865A (ja) *	1982-09-30	1984-04-05	Ube Ind Ltd	耐熱鋳鋼
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US5102886A (en)	1990-10-12	1992-04-07	American Home Products Corporation	1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors
IL102764A0 (en) *	1991-08-16	1993-01-31	Merck & Co Inc	Quinazoline derivatives,and pharmaceutical compositions containing them
WO2000066560A1 (en)	1999-05-04	2000-11-09	American Home Products Corporation	Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
AP1699A (en) *	2001-03-21	2006-12-26	Warner Lambert Co	New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
US6596167B2 (en)	2001-03-26	2003-07-22	Koch Membrane Systems, Inc.	Hydrophilic hollow fiber ultrafiltration membranes that include a hydrophobic polymer and a method of making these membranes

2002
- 2002-09-17 EP EP20020292275 patent/EP1400244A1/en not_active Withdrawn
2003
- 2003-09-08 EP EP20030797455 patent/EP1542694A1/en not_active Withdrawn
- 2003-09-08 KR KR1020057004511A patent/KR20050057371A/ko not_active Application Discontinuation
- 2003-09-08 WO PCT/IB2003/003965 patent/WO2004026818A1/en active Application Filing
- 2003-09-08 MX MXPA05002913A patent/MXPA05002913A/es active IP Right Grant
- 2003-09-08 BR BR0314379A patent/BR0314379A/pt not_active IP Right Cessation
- 2003-09-08 PL PL37597703A patent/PL375977A1/xx not_active Application Discontinuation
- 2003-09-08 OA OA1200500073A patent/OA12924A/en unknown
- 2003-09-08 EA EA200500312A patent/EA200500312A1/ru unknown
- 2003-09-08 AU AU2003259496A patent/AU2003259496A1/en not_active Abandoned
- 2003-09-08 CA CA 2499330 patent/CA2499330C/en not_active Expired - Fee Related
- 2003-09-08 CN CNA038221284A patent/CN1681507A/zh active Pending
- 2003-09-08 AP AP2005003251A patent/AP2005003251A0/xx unknown
- 2003-09-08 JP JP2004537412A patent/JP2006501277A/ja not_active Withdrawn
- 2003-09-16 AR ARP030103355 patent/AR041271A1/es unknown
- 2003-09-16 TW TW92125477A patent/TWI251590B/zh not_active IP Right Cessation
- 2003-09-16 PE PE2003000943A patent/PE20050073A1/es not_active Application Discontinuation
- 2003-09-16 PA PA8582801A patent/PA8582801A1/es unknown
- 2003-09-17 UY UY27986A patent/UY27986A1/es not_active Application Discontinuation
- 2003-09-17 US US10/667,111 patent/US7429598B2/en not_active Expired - Fee Related
- 2003-09-17 HN HN2003000285A patent/HN2003000285A/es unknown
- 2003-09-17 GT GT200300201A patent/GT200300201A/es unknown
2005
- 2005-02-16 ZA ZA200501381A patent/ZA200501381B/xx unknown
- 2005-02-17 IS IS7700A patent/IS7700A/is unknown
- 2005-03-08 HR HR20050223A patent/HRP20050223A2/hr not_active Application Discontinuation
- 2005-03-10 CR CR7728A patent/CR7728A/es not_active Application Discontinuation
- 2005-03-11 EC ECSP055671 patent/ECSP055671A/es unknown
- 2005-03-16 CO CO05024530A patent/CO5540391A2/es not_active Application Discontinuation
- 2005-03-17 TN TNP2005000073A patent/TNSN05073A1/fr unknown
- 2005-03-17 MA MA28153A patent/MA27439A1/fr unknown
- 2005-04-05 NO NO20051695A patent/NO20051695L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AR041271A1 (es)	2005-05-11
GT200300201A (es)	2004-05-18
PL375977A1 (en)	2005-12-12
EP1400244A1 (en)	2004-03-24
UY27986A1 (es)	2004-04-30
TWI251590B (en)	2006-03-21
AP2005003251A0 (en)	2005-03-31
AU2003259496A1 (en)	2004-04-08
BR0314379A (pt)	2005-07-19
JP2006501277A (ja)	2006-01-12
PE20050073A1 (es)	2005-02-28
US20040106631A1 (en)	2004-06-03
EP1542694A1 (en)	2005-06-22
CA2499330C (en)	2009-04-28
TW200413333A (en)	2004-08-01
ECSP055671A (es)	2005-05-30
PA8582801A1 (es)	2004-05-26
KR20050057371A (ko)	2005-06-16
HN2003000285A (es)	2004-11-23
MXPA05002913A (es)	2005-05-27
HRP20050223A2 (en)	2005-10-31
WO2004026818A1 (en)	2004-04-01
EA200500312A1 (ru)	2005-08-25
NO20051695L (no)	2005-04-05
US7429598B2 (en)	2008-09-30
CO5540391A2 (es)	2005-07-29
CR7728A (es)	2005-06-08
CN1681507A (zh)	2005-10-12
CA2499330A1 (en)	2004-04-01
IS7700A (is)	2005-02-17
OA12924A (en)	2006-10-13
TNSN05073A1 (fr)	2007-05-14
MA27439A1 (fr)	2005-07-01

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