ZA200504059B - External composition containing polyunsaturated fatty acid or its salt or ester - Google Patents
External composition containing polyunsaturated fatty acid or its salt or ester Download PDFInfo
- Publication number
- ZA200504059B ZA200504059B ZA200504059A ZA200504059A ZA200504059B ZA 200504059 B ZA200504059 B ZA 200504059B ZA 200504059 A ZA200504059 A ZA 200504059A ZA 200504059 A ZA200504059 A ZA 200504059A ZA 200504059 B ZA200504059 B ZA 200504059B
- Authority
- ZA
- South Africa
- Prior art keywords
- fatty acid
- ester
- external composition
- polyunsaturated fatty
- composition according
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 96
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 title claims description 71
- 150000002148 esters Chemical class 0.000 title claims description 39
- 150000003839 salts Chemical class 0.000 title claims description 29
- 230000003078 antioxidant effect Effects 0.000 claims description 107
- 235000003434 Sesamum indicum Nutrition 0.000 claims description 83
- 241000207961 Sesamum Species 0.000 claims description 79
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 76
- 239000003963 antioxidant agent Substances 0.000 claims description 69
- 235000006708 antioxidants Nutrition 0.000 claims description 69
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 58
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 58
- -1 ascorbyl fatty acid ester Chemical class 0.000 claims description 58
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 58
- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 claims description 55
- LUSZGTFNYDARNI-UHFFFAOYSA-N Sesamol Natural products OC1=CC=C2OCOC2=C1 LUSZGTFNYDARNI-UHFFFAOYSA-N 0.000 claims description 54
- 239000000463 material Substances 0.000 claims description 51
- 239000011732 tocopherol Substances 0.000 claims description 48
- 229960001295 tocopherol Drugs 0.000 claims description 47
- 235000021323 fish oil Nutrition 0.000 claims description 46
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 44
- 229930195729 fatty acid Natural products 0.000 claims description 44
- 239000000194 fatty acid Substances 0.000 claims description 44
- 239000003921 oil Substances 0.000 claims description 40
- 235000019198 oils Nutrition 0.000 claims description 39
- 230000001590 oxidative effect Effects 0.000 claims description 39
- 229960005070 ascorbic acid Drugs 0.000 claims description 37
- 235000010323 ascorbic acid Nutrition 0.000 claims description 35
- 239000011668 ascorbic acid Substances 0.000 claims description 35
- 239000002674 ointment Substances 0.000 claims description 34
- 238000012360 testing method Methods 0.000 claims description 28
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 27
- 239000001301 oxygen Substances 0.000 claims description 27
- 229910052760 oxygen Inorganic materials 0.000 claims description 27
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims description 22
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 22
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims description 19
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 19
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 17
- 239000000470 constituent Substances 0.000 claims description 15
- 235000011803 sesame oil Nutrition 0.000 claims description 15
- 239000008159 sesame oil Substances 0.000 claims description 15
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- 239000004202 carbamide Substances 0.000 claims description 12
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- 235000020669 docosahexaenoic acid Nutrition 0.000 claims description 11
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims description 11
- HGXBRUKMWQGOIE-WZBLMQSHSA-N epipinoresinol Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@@H]3[C@@H]([C@@H](OC3)C=3C=C(OC)C(O)=CC=3)CO2)=C1 HGXBRUKMWQGOIE-WZBLMQSHSA-N 0.000 claims description 11
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- 150000002978 peroxides Chemical class 0.000 claims description 10
- 239000004166 Lanolin Substances 0.000 claims description 9
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims description 9
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- 229960005135 eicosapentaenoic acid Drugs 0.000 claims description 9
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims description 9
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- 229940039717 lanolin Drugs 0.000 claims description 9
- 150000002632 lipids Chemical class 0.000 claims description 9
- LITUBCVUXPBCGA-WMZHIEFXSA-N Ascorbyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O LITUBCVUXPBCGA-WMZHIEFXSA-N 0.000 claims description 8
- 239000003995 emulsifying agent Substances 0.000 claims description 8
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- 238000000034 method Methods 0.000 claims description 7
- 239000002904 solvent Substances 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 6
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- 239000000839 emulsion Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- OHOPKHNWLCMLSW-UHFFFAOYSA-N pinoresinol Natural products C1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C(CO)C(O)=CC=3)CO2)=C1 OHOPKHNWLCMLSW-UHFFFAOYSA-N 0.000 claims description 5
- 235000007221 pinoresinol Nutrition 0.000 claims description 5
- BURBOJZOZGMMQF-UHFFFAOYSA-N xanthoxylol Natural products C1=C(O)C(OC)=CC=C1C1C(COC2C=3C=C4OCOC4=CC=3)C2CO1 BURBOJZOZGMMQF-UHFFFAOYSA-N 0.000 claims description 5
- OJVGWDJIYBTWDS-UHFFFAOYSA-N Sesamolinol Natural products C1=C(O)C(OC)=CC(OC2C3C(C(OC3)C=3C=C4OCOC4=CC=3)CO2)=C1 OJVGWDJIYBTWDS-UHFFFAOYSA-N 0.000 claims description 4
- KQRXQIPRDKVZPW-ISZNXKAUSA-N sesaminol Chemical compound C1=C2OCOC2=CC([C@H]2OC[C@H]3[C@@H]2CO[C@@H]3C2=CC=3OCOC=3C=C2O)=C1 KQRXQIPRDKVZPW-ISZNXKAUSA-N 0.000 claims description 4
- KQRXQIPRDKVZPW-UHFFFAOYSA-N sesaminol Natural products C1=C2OCOC2=CC(C2OCC3C2COC3C2=CC=3OCOC=3C=C2O)=C1 KQRXQIPRDKVZPW-UHFFFAOYSA-N 0.000 claims description 4
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 4
- OJVGWDJIYBTWDS-AFHBHXEDSA-N Sesamolinol Chemical compound C1=C(O)C(OC)=CC(O[C@@H]2[C@@H]3[C@@H]([C@H](OC3)C=3C=C4OCOC4=CC=3)CO2)=C1 OJVGWDJIYBTWDS-AFHBHXEDSA-N 0.000 claims description 3
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- 238000000605 extraction Methods 0.000 claims description 3
- 239000011261 inert gas Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- KOWMJRJXZMEZLD-UHFFFAOYSA-N syringaresinol Chemical compound COC1=C(O)C(OC)=CC(C2C3C(C(OC3)C=3C=C(OC)C(O)=C(OC)C=3)CO2)=C1 KOWMJRJXZMEZLD-UHFFFAOYSA-N 0.000 claims description 3
- LVUPFEOCDSHRBL-UHFFFAOYSA-N syringaresinol Natural products COc1cccc(OC)c1C2OCC3C2COC3c4c(OC)cccc4OC LVUPFEOCDSHRBL-UHFFFAOYSA-N 0.000 claims description 3
- FRGPGYZDYMDICG-UHFFFAOYSA-N 3,4-bis[(4-hydroxy-3-methoxyphenyl)methyl]-2h-furan-5-one Chemical compound C1=C(O)C(OC)=CC(CC=2COC(=O)C=2CC=2C=C(OC)C(O)=CC=2)=C1 FRGPGYZDYMDICG-UHFFFAOYSA-N 0.000 claims description 2
- 125000003289 ascorbyl group Chemical group [H]O[C@@]([H])(C([H])([H])O*)[C@@]1([H])OC(=O)C(O*)=C1O* 0.000 claims description 2
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- 230000000052 comparative effect Effects 0.000 description 24
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- 150000004665 fatty acids Chemical class 0.000 description 11
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- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Fats And Perfumes (AREA)
- Edible Oils And Fats (AREA)
- Cosmetics (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Medicinal Preparation (AREA)
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ZA200504059A ZA200504059B (en) | 2002-11-22 | 2003-11-21 | External composition containing polyunsaturated fatty acid or its salt or ester |
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US (2) | US8722104B2 (ko) |
EP (2) | EP1571195A4 (ko) |
JP (2) | JPWO2004048497A1 (ko) |
KR (3) | KR20050083960A (ko) |
CN (2) | CN100348184C (ko) |
AU (2) | AU2003284633B2 (ko) |
CA (1) | CA2506611A1 (ko) |
NZ (1) | NZ540154A (ko) |
TW (2) | TW200417595A (ko) |
WO (2) | WO2004048496A1 (ko) |
ZA (1) | ZA200504059B (ko) |
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TWI332978B (ko) | 2010-11-11 |
WO2004048497A1 (ja) | 2004-06-10 |
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AU2003284617A1 (en) | 2004-06-18 |
JP4424743B2 (ja) | 2010-03-03 |
JPWO2004048497A1 (ja) | 2006-03-30 |
US8722104B2 (en) | 2014-05-13 |
CA2506611A1 (en) | 2004-06-10 |
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