ZA200207423B - Polyglutamic acid-camptothecin conjugates and methods of preparation. - Google Patents
Polyglutamic acid-camptothecin conjugates and methods of preparation. Download PDFInfo
- Publication number
- ZA200207423B ZA200207423B ZA200207423A ZA200207423A ZA200207423B ZA 200207423 B ZA200207423 B ZA 200207423B ZA 200207423 A ZA200207423 A ZA 200207423A ZA 200207423 A ZA200207423 A ZA 200207423A ZA 200207423 B ZA200207423 B ZA 200207423B
- Authority
- ZA
- South Africa
- Prior art keywords
- camptothecin
- composition
- polyglutamic acid
- conjugate
- cpt
- Prior art date
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- 229940127093 camptothecin Drugs 0.000 title claims description 251
- 238000000034 method Methods 0.000 title claims description 42
- 238000002360 preparation method Methods 0.000 title description 7
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 173
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 170
- 239000000203 mixture Substances 0.000 claims description 115
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 99
- 239000000243 solution Substances 0.000 claims description 94
- 229920002643 polyglutamic acid Polymers 0.000 claims description 61
- 229920000642 polymer Polymers 0.000 claims description 46
- 108010020346 Polyglutamic Acid Proteins 0.000 claims description 39
- HAWSQZCWOQZXHI-FQEVSTJZSA-N 10-Hydroxycamptothecin Chemical compound C1=C(O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 HAWSQZCWOQZXHI-FQEVSTJZSA-N 0.000 claims description 25
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| ZA200207423A ZA200207423B (en) | 2000-03-17 | 2002-09-16 | Polyglutamic acid-camptothecin conjugates and methods of preparation. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20020016285A1 (fr) |
| EP (1) | EP1267939A2 (fr) |
| JP (1) | JP2003527443A (fr) |
| KR (1) | KR20020082888A (fr) |
| CN (1) | CN1429121A (fr) |
| AU (1) | AU2001247513A1 (fr) |
| BR (1) | BR0109272A (fr) |
| CA (1) | CA2402643A1 (fr) |
| CZ (1) | CZ20023330A3 (fr) |
| HU (1) | HUP0204562A2 (fr) |
| IL (1) | IL151685A0 (fr) |
| MX (1) | MXPA02009082A (fr) |
| NO (1) | NO20024421L (fr) |
| PL (1) | PL358335A1 (fr) |
| RU (1) | RU2002128610A (fr) |
| SI (1) | SI21172A (fr) |
| SK (1) | SK14822002A3 (fr) |
| TR (1) | TR200202194T2 (fr) |
| WO (1) | WO2001070275A2 (fr) |
| ZA (1) | ZA200207423B (fr) |
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| PT2155255E (pt) * | 2007-05-09 | 2013-10-15 | Nitto Denko Corp | Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido |
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| KR101589582B1 (ko) * | 2008-03-18 | 2016-01-28 | 니폰 가야꾸 가부시끼가이샤 | 생리활성물질의 고분자량 결합체 |
| WO2009136572A1 (fr) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | Conjugué de polymère avec l'acide folique ou un dérivé de l'acide folique |
| JP2011162569A (ja) | 2008-05-23 | 2011-08-25 | Nano Career Kk | カンプトテシン高分子誘導体及びその用途 |
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| ES2970117T3 (es) | 2015-06-26 | 2024-05-27 | Celgene Corp | Métodos para el tratamiento de sarcoma de Kaposi o linfoma inducido por KSHV usando compuestos inmunomoduladores, y usos de biomarcadores |
| CN106267227A (zh) * | 2016-08-12 | 2017-01-04 | 北京蓝贝望生物医药科技股份有限公司 | 抗肿瘤药物 |
| EP3518954A4 (fr) * | 2016-09-30 | 2020-05-27 | If7Cure, Inc | Procédé de fabrication d'un agent antitumoral ciblant le réseau vasculaire tumoral |
| CN106831853B (zh) * | 2017-02-15 | 2019-02-22 | 浙江海正药业股份有限公司 | 7-乙基-10-o-叔丁基二苯基硅基喜树碱-20-o-甘氨酸盐酸盐的制备工艺 |
| CN108727581A (zh) * | 2017-04-18 | 2018-11-02 | 华东师范大学 | 以苯硼酸酯为连接单元的两亲性喜树碱高分子前药及其制备方法和应用 |
| JP2021095424A (ja) * | 2018-03-28 | 2021-06-24 | 持田製薬株式会社 | 抗癌剤結合アルギン酸誘導体 |
| CN115298189B (zh) * | 2019-12-04 | 2024-08-30 | 丹塔里股份有限公司 | 合成治疗性纳米颗粒的方法和组合物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
| US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| AU735900B2 (en) * | 1996-03-12 | 2001-07-19 | Pg-Txl Company, L.P. | Water soluble paclitaxel prodrugs |
-
2001
- 2001-03-19 WO PCT/US2001/008553 patent/WO2001070275A2/fr not_active Application Discontinuation
- 2001-03-19 EP EP01920466A patent/EP1267939A2/fr not_active Withdrawn
- 2001-03-19 RU RU2002128610/15A patent/RU2002128610A/ru unknown
- 2001-03-19 CA CA002402643A patent/CA2402643A1/fr not_active Abandoned
- 2001-03-19 JP JP2001568471A patent/JP2003527443A/ja not_active Withdrawn
- 2001-03-19 CZ CZ20023330A patent/CZ20023330A3/cs unknown
- 2001-03-19 AU AU2001247513A patent/AU2001247513A1/en not_active Abandoned
- 2001-03-19 MX MXPA02009082A patent/MXPA02009082A/es unknown
- 2001-03-19 CN CN01809441A patent/CN1429121A/zh active Pending
- 2001-03-19 KR KR1020027012206A patent/KR20020082888A/ko not_active Application Discontinuation
- 2001-03-19 SI SI200120021A patent/SI21172A/sl not_active IP Right Cessation
- 2001-03-19 US US09/810,345 patent/US20020016285A1/en not_active Abandoned
- 2001-03-19 SK SK1482-2002A patent/SK14822002A3/sk unknown
- 2001-03-19 IL IL15168501A patent/IL151685A0/xx unknown
- 2001-03-19 PL PL01358335A patent/PL358335A1/xx not_active Application Discontinuation
- 2001-03-19 BR BR0109272-3A patent/BR0109272A/pt active Pending
- 2001-03-19 HU HU0204562A patent/HUP0204562A2/hu unknown
- 2001-03-19 TR TR2002/02194T patent/TR200202194T2/xx unknown
-
2002
- 2002-09-16 NO NO20024421A patent/NO20024421L/no not_active Application Discontinuation
- 2002-09-16 ZA ZA200207423A patent/ZA200207423B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0204562A2 (hu) | 2003-04-28 |
| TR200202194T2 (tr) | 2003-01-21 |
| MXPA02009082A (es) | 2003-12-11 |
| PL358335A1 (en) | 2004-08-09 |
| SI21172A (sl) | 2003-10-31 |
| WO2001070275A3 (fr) | 2002-01-03 |
| NO20024421D0 (no) | 2002-09-16 |
| WO2001070275A2 (fr) | 2001-09-27 |
| JP2003527443A (ja) | 2003-09-16 |
| KR20020082888A (ko) | 2002-10-31 |
| RU2002128610A (ru) | 2004-03-27 |
| AU2001247513A1 (en) | 2001-10-03 |
| CA2402643A1 (fr) | 2001-09-27 |
| IL151685A0 (en) | 2003-04-10 |
| CN1429121A (zh) | 2003-07-09 |
| US20020016285A1 (en) | 2002-02-07 |
| SK14822002A3 (sk) | 2003-05-02 |
| CZ20023330A3 (cs) | 2003-02-12 |
| BR0109272A (pt) | 2004-06-29 |
| NO20024421L (no) | 2002-11-15 |
| EP1267939A2 (fr) | 2003-01-02 |
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