YU48973B - 3(2h)-piridazinon derivati i postupak za njihovo dobijanje - Google Patents
3(2h)-piridazinon derivati i postupak za njihovo dobijanjeInfo
- Publication number
- YU48973B YU48973B YU109292A YU109292A YU48973B YU 48973 B YU48973 B YU 48973B YU 109292 A YU109292 A YU 109292A YU 109292 A YU109292 A YU 109292A YU 48973 B YU48973 B YU 48973B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- substituent
- hydrogen
- alkyl
- group
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
3(2H)-piridazinon derivati opšte formule (I): naznačeni time, što R1 je vodonik; fenil; metil koji opciono nosi benziloksi supstituent; C2-4 alkil koji opciono nosi supstituet formule R8R9N-, gde R8 i R9 su nezavisno C1-4 alkil, ili R8 i R9 formiraju, zajedno sa susednim atomima azota, 6-članu heterocikličnu grupu koja opciono sadrži atom kiseonika ili grupu formule R10N-, gde R10 je C1-4 aklil koji opiciono sadrži fenoksi supstituent, ili C3-5 alkenil koji opciono nosi fenil supstituent, dalje pomenuti C1-4 alkil je opciono suspstituisan sa fenilom koji nosi metoksi ili metansulfonilamino supstituent; ili C3-5 alkenil koji opciono nosi fenil ili halofenil supstituent, A i B su vodonik, halogen ili grupa opšte formule (II), gde R2 i R3 su nezavisno vodonik ili C1-4 alkil, ili zajedno sa susednom-N-(CH2)nN-grupom formiraju piperazin ili homopiperazin prsten; R4 je vodonik, C1-4 alkil ili fenil; R5, R6 i R7 svaki su vodonik, C1-4 alkoksi ili amino koji opciono nosi metansulfonil supstituent; X je jednostruka valentna veza, atom kiseonika ili grupa formule-CH=CH; m je 0 ili 1, i n je 2 ili 3 uz uslov da A i B su uvek različiti, i ako jedan A i B je vodonik ili halogen, drugi je grupa opšte formule (II), i njihove adicione soli kiseline. Prijava sadrži još 12 nezavisnih zahteva.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| YU109292A YU48973B (sh) | 1991-12-20 | 1992-12-18 | 3(2h)-piridazinon derivati i postupak za njihovo dobijanje |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU914057A HU214320B (hu) | 1991-12-20 | 1991-12-20 | Eljárás új 3(2H)-piridazinon-származékok és ezeket tartalmazó gyógyszerkészítmények előállítására |
| YU109292A YU48973B (sh) | 1991-12-20 | 1992-12-18 | 3(2h)-piridazinon derivati i postupak za njihovo dobijanje |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU109292A YU109292A (sr) | 1996-01-09 |
| YU48973B true YU48973B (sh) | 2003-02-28 |
Family
ID=10966710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU109292A YU48973B (sh) | 1991-12-20 | 1992-12-18 | 3(2h)-piridazinon derivati i postupak za njihovo dobijanje |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5395934A (sh) |
| JP (1) | JP3165935B2 (sh) |
| KR (1) | KR100234596B1 (sh) |
| CN (1) | CN1088578A (sh) |
| AT (1) | AT403282B (sh) |
| BE (1) | BE1006223A4 (sh) |
| CA (1) | CA2085796C (sh) |
| CH (1) | CH684754A5 (sh) |
| CZ (1) | CZ286039B6 (sh) |
| DE (1) | DE4243381B4 (sh) |
| DK (1) | DK152892A (sh) |
| ES (1) | ES2108595B1 (sh) |
| FI (1) | FI106374B (sh) |
| FR (1) | FR2685329B1 (sh) |
| GB (1) | GB2262526B (sh) |
| GR (1) | GR1002281B (sh) |
| HU (1) | HU214320B (sh) |
| NL (1) | NL194966C (sh) |
| PL (1) | PL172933B1 (sh) |
| RU (1) | RU2130019C1 (sh) |
| YU (1) | YU48973B (sh) |
| ZA (1) | ZA929903B (sh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969017A (en) * | 1996-10-31 | 1999-10-19 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| US5935945A (en) * | 1996-10-31 | 1999-08-10 | Merck & Co., Inc. | Methods of treating or preventing cardiac arrhythmia |
| CA2334220A1 (en) | 1998-06-05 | 1999-12-16 | Egis Gyogyszergyar Rt. | Process for the preparation of a 3(2h)-pyridazinone- 4-substituted amino- 5-chloro- derivative |
| ES2162731B1 (es) * | 1999-06-04 | 2003-02-16 | Faes Fabrica Espanola De Produ | Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas. |
| WO2001034151A1 (en) * | 1999-11-11 | 2001-05-17 | Fred Hutchinson Cancer Research Center | Novel topoisomerase poisons for the treatment of proliferative disorders |
| US7173063B1 (en) | 2000-11-10 | 2007-02-06 | Fred Hutchinson Cancer Research Center | Topoisomerase poisons for the treatment of proliferative disorders |
| HUP0103064A3 (en) * | 2001-07-26 | 2005-06-28 | Egis Gyogyszergyar Nyilvanosan | Polymorphic form of 5-chloro-4-(3-{[2-(3,4-dimethoxy-phenyl)-ethyl]-methyl-amino]-propylamino)-3-(2h)-piridazinone fumarate, its use, process for its preparation and pharmaceutical compositions containing it |
| HU227237B1 (en) * | 2001-09-27 | 2010-12-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them |
| CA2474239A1 (en) * | 2002-01-18 | 2003-07-24 | Pharmacia Corporation | Substituted pyridazinones as inhibitors of p38 |
| HU227181B1 (en) * | 2002-09-11 | 2010-09-28 | Egis Gyogyszergyar Nyilvanosan | Use of 5-chloro-4-[3-[n-[2-(3,4-dimethoxyphenyl)ethyl)]-n-methylamino]-propylamino]-3-(2h)-pyridazinone for producing pharmaceutical compositions having metabolic modulator effect |
| WO2011062437A2 (ko) * | 2009-11-20 | 2011-05-26 | 에스케이케미칼주식회사 | 고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물 |
| WO2011097553A1 (en) * | 2010-02-08 | 2011-08-11 | Allergan, Inc. | Pyridazine derivatives useful as cannabinoid - 2 agonists |
| FR2969606B1 (fr) * | 2010-12-22 | 2013-01-11 | Pf Medicament | Derives de diarylpyridazinones, leur preparation et leur application en therapeutique humaine |
| RU2455004C1 (ru) * | 2011-04-01 | 2012-07-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный технический университет" (ФГБОУ ВПО "ЯГТУ") | Способ получения сульфохлоридов ряда 6-арилпиридазин-3(2н)-онов |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1285235A (fr) * | 1960-01-21 | 1962-02-23 | Ciba Geigy | Procédé de préparation de nouvelles diazines, notamment de 1-aryl-3-r-5-r'pyridazones-(6) dans lesquelles r représente un hydroxyle aliphatiquement éthérifié et r' représente un groupe n-(beta-aryl-éthyl)-pipérazino |
| US4088764A (en) * | 1973-12-27 | 1978-05-09 | Cassella Farbwerke Mainkur Aktiengesellschaft | Pharmaceutically active derivatives of 1-phenoxy-3-amino-propan-2-ol |
| DE3048487A1 (de) * | 1980-12-22 | 1982-07-29 | Cassella Ag, 6000 Frankfurt | Basisch substituierte pyridazine, ihre herstellung und ihre verwendung |
| JPH0641454B2 (ja) * | 1985-02-27 | 1994-06-01 | 日産化学工業株式会社 | ピリダジノン誘導体 |
| US4892947A (en) * | 1985-04-27 | 1990-01-09 | Nissan Chemical Industries Ltd. | 3(2H)Pyridazinone, process for its preparation and anti-allergic agent containing it |
| US4992433A (en) * | 1987-11-23 | 1991-02-12 | Janssen Pharmaceutica N.V. | Novel pyridazinamine derivatives |
| MY104343A (en) * | 1987-11-23 | 1994-03-31 | Janssen Pharmaceutica Nv | Novel pyridizinamine deravatives |
| AU610204B2 (en) * | 1988-03-17 | 1991-05-16 | Institut Fiziologicheski Aktivnykh Veschestv Akademii Nauk SSSR | Method of sterilizing anthers utilizing derivatives of phosphoric acid |
| IE62890B1 (en) * | 1988-12-06 | 1995-03-08 | Hafslund Nycomed Pharma | New piperazinylalkyl-3(2h)-pyridazinones process for the preparation thereof and the use thereof as agents lowering blood pressure |
| DE3902316A1 (de) * | 1989-01-26 | 1990-08-02 | Lentia Gmbh | Neue piperazinylalkyl-3(2h)-pyridazinone, verfahren zu ihrer herstellung und ihre verwendung als blutdrucksenkende mittel |
-
1991
- 1991-12-20 HU HU914057A patent/HU214320B/hu not_active IP Right Cessation
-
1992
- 1992-12-18 YU YU109292A patent/YU48973B/sh unknown
- 1992-12-18 ES ES09202568A patent/ES2108595B1/es not_active Expired - Fee Related
- 1992-12-18 CN CN92113725A patent/CN1088578A/zh active Pending
- 1992-12-18 PL PL92297070A patent/PL172933B1/pl not_active IP Right Cessation
- 1992-12-18 RU RU92016234A patent/RU2130019C1/ru not_active IP Right Cessation
- 1992-12-18 CA CA002085796A patent/CA2085796C/en not_active Expired - Fee Related
- 1992-12-18 FR FR9215297A patent/FR2685329B1/fr not_active Expired - Fee Related
- 1992-12-18 BE BE9201106A patent/BE1006223A4/fr not_active IP Right Cessation
- 1992-12-18 CH CH3869/92A patent/CH684754A5/de not_active IP Right Cessation
- 1992-12-21 KR KR1019920024844A patent/KR100234596B1/ko not_active IP Right Cessation
- 1992-12-21 GR GR920100570A patent/GR1002281B/el not_active IP Right Cessation
- 1992-12-21 GB GB9226601A patent/GB2262526B/en not_active Expired - Fee Related
- 1992-12-21 CZ CS923809A patent/CZ286039B6/cs not_active IP Right Cessation
- 1992-12-21 DE DE4243381A patent/DE4243381B4/de not_active Expired - Fee Related
- 1992-12-21 ZA ZA929903A patent/ZA929903B/xx unknown
- 1992-12-21 JP JP35639792A patent/JP3165935B2/ja not_active Expired - Fee Related
- 1992-12-21 FI FI925807A patent/FI106374B/fi not_active IP Right Cessation
- 1992-12-21 NL NL9202210A patent/NL194966C/nl not_active IP Right Cessation
- 1992-12-21 AT AT0253592A patent/AT403282B/de active
- 1992-12-21 US US07/995,295 patent/US5395934A/en not_active Expired - Fee Related
- 1992-12-21 DK DK152892A patent/DK152892A/da unknown
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