Nothing Special   »   [go: up one dir, main page]

YU46978B - Postupak za dobijanje preparata za nazalnu upotrebu - Google Patents

Postupak za dobijanje preparata za nazalnu upotrebu

Info

Publication number
YU46978B
YU46978B YU228487A YU228487A YU46978B YU 46978 B YU46978 B YU 46978B YU 228487 A YU228487 A YU 228487A YU 228487 A YU228487 A YU 228487A YU 46978 B YU46978 B YU 46978B
Authority
YU
Yugoslavia
Prior art keywords
water
phospholipid
resulting solution
procedure
solution
Prior art date
Application number
YU228487A
Other languages
English (en)
Other versions
YU228487A (en
Inventor
Ph.E. Hansen
A.R. Sorensen
Original Assignee
Novo Nordisk A/S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DK604286A external-priority patent/DK604286D0/da
Priority claimed from DK370087A external-priority patent/DK370087D0/da
Application filed by Novo Nordisk A/S. filed Critical Novo Nordisk A/S.
Priority to SI8712284A priority Critical patent/SI8712284B/sl
Publication of YU228487A publication Critical patent/YU228487A/xx
Priority to HRP-2284/87A priority patent/HRP930276B1/xx
Publication of YU46978B publication Critical patent/YU46978B/sh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

POSTUPAK ZA DOBIJANJE PREPARATA ZA NAZALNU UPOTREBU naznačen time, što se aktivni polipeptid rastvara u vodi u prisustvu kiseline, što se odvojeno obrazuje rastvor konzervansa kao što je krezol ili metil p-hidroksibenzoat, i poželjno agensa koji rastvor čini izotoničnim i/ili agensa puferovanja, pa se potom napred pomenuti rastvori mešaju, a zatim se dobijeni rastvor neutrališe dodavanjem baze, što se potom fosfolipid opšte formule I u kojoj su R' i R" isti ili različiti i svaki predstavlja vodonik, alkil, alkenil, alkilkarbonil, alkenilkarbonil, alkadienkarbonil, alkatrienilkarbonil ili alkatetraenilkarbonil grupu koja ne sadrži više od 14 atoma ugljenika pod uslovom da oba R' i R" istovremeno nisu vodonik i R"' predstavlja hidrofilnu grupu kao što je 2-(trimetilamonijum)etil, 2-aminoetil, ili 2,3-dihidroksipropil, disperguje u vodi putem ultra zvučnog tretmana, s tim što fosfolipid može prethodno biti rastvoren u masnom ulju, a potom se vrši disprergovanje u vodi; i što se potom disperzija fosfolipida dodaje dobijeom rastvoru neutralisanom dodavanjem baze, pa se dodaje voda dobijenom rastvoru. Prijava sadrži još 9 zavisnih zahteva.
YU228487A 1986-12-16 1987-12-16 Postupak za dobijanje preparata za nazalnu upotrebu YU46978B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8712284A SI8712284B (sl) 1986-12-16 1987-12-16 Pripravki za nazalno uporabo in postopki za njihovo pridobivanje
HRP-2284/87A HRP930276B1 (en) 1986-12-16 1993-03-08 Process for obtaining a preparation for nasal use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK604286A DK604286D0 (da) 1986-12-16 1986-12-16 Praeparat
DK370087A DK370087D0 (da) 1987-07-16 1987-07-16 Produkt med forbedrede egenskaber

Publications (2)

Publication Number Publication Date
YU228487A YU228487A (en) 1988-12-31
YU46978B true YU46978B (sh) 1994-09-09

Family

ID=26067181

Family Applications (1)

Application Number Title Priority Date Filing Date
YU228487A YU46978B (sh) 1986-12-16 1987-12-16 Postupak za dobijanje preparata za nazalnu upotrebu

Country Status (22)

Country Link
EP (1) EP0272097B1 (sh)
JP (1) JPH0768149B2 (sh)
KR (1) KR890700036A (sh)
CN (1) CN1034105C (sh)
AT (1) ATE79039T1 (sh)
AU (1) AU606121B2 (sh)
CA (1) CA1326210C (sh)
CS (1) CS273139B1 (sh)
DE (1) DE3780925T2 (sh)
ES (1) ES2044957T3 (sh)
FI (1) FI94024C (sh)
GR (1) GR3005381T3 (sh)
HU (1) HU209247B (sh)
IE (1) IE61110B1 (sh)
IL (1) IL84835A (sh)
MX (1) MX9203640A (sh)
NO (1) NO175566C (sh)
NZ (1) NZ222907A (sh)
PT (1) PT86370B (sh)
RU (1) RU1837869C (sh)
WO (1) WO1988004556A1 (sh)
YU (1) YU46978B (sh)

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5690954A (en) * 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
US5645820A (en) * 1987-06-24 1997-07-08 Autoimmune, Inc. Treatment of autoimmune diseases by aerosol administration of autoantigens
US5571500A (en) * 1987-06-24 1996-11-05 Autoimmune, Inc. Treatment of autoimmune diseases through administration by inhalation of autoantigens
US5571499A (en) * 1987-06-24 1996-11-05 Autoimmune, Inc. Treatment of autoimmune diseases by aerosol administration of autoantigens
US5641474A (en) * 1987-06-24 1997-06-24 Autoimmune, Inc. Prevention of autoimmune diseases by aerosol administration of autoantigens
US5849298A (en) * 1987-06-24 1998-12-15 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of bovine myelin
PT88490B (pt) * 1987-09-14 1992-11-30 Novo Nordisk As Processo para a preparacao de composicoes farmaceuticas para libertacao nao-enterica trans-mucosa contendo monossacaridos ou oligossacaridos
GB8723846D0 (en) * 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
GB2212062B (en) * 1987-11-13 1991-07-17 Isf Spa Pharmaceutical compositions containing a calcitonin and a glycyrrhizinate ab- sorption enhancer
GB8822857D0 (en) * 1988-09-29 1988-11-02 Patralan Ltd Pharmaceutical formulations
ATE138071T1 (de) * 1989-02-17 1996-06-15 Liposome Co Inc Lipidhilfstoffe für verabreichung durch die nase und örtliche anwendung
IT8920486A0 (it) * 1989-05-12 1989-05-12 Isf Spa Composizioni farmaceutiche.
US5725871A (en) * 1989-08-18 1998-03-10 Danbiosyst Uk Limited Drug delivery compositions comprising lysophosphoglycerolipid
GB8918879D0 (en) * 1989-08-18 1989-09-27 Danbiosyst Uk Pharmaceutical compositions
GB9007052D0 (en) * 1990-03-29 1990-05-30 Skua Investments Ltd Pharmaceutical formulations
GB9012663D0 (en) * 1990-06-07 1990-08-01 Erba Carlo Spa Galenic formulations containing cyclodextrins
IL99699A (en) * 1990-10-10 2002-04-21 Autoimmune Inc Drug with the option of oral, intra-intestinal, or inhaled dosing for suppression of autoimmune response associated with type I diabetes
IT1250691B (it) 1991-07-22 1995-04-21 Giancarlo Santus Composizioni terapeutiche per somministrazione intranasale comprendenti ketorolac.
DK36492D0 (da) * 1992-03-19 1992-03-19 Novo Nordisk As Praeparat
CA2094217A1 (en) * 1992-04-17 1993-10-18 Yasutaka Igari Transmucosal therapeutic composition
DE4214953C2 (de) * 1992-05-06 1995-05-18 Arrowdean Ltd Arzneimittel zur Erhöhung des Testosteronspiegels
DE4218291A1 (de) * 1992-06-03 1993-12-09 Mattern Et Partner Pharmazeuti Dosierspray für pernasale Applikation
US6582728B1 (en) 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
SI9300468A (en) * 1992-10-14 1994-06-30 Hoffmann La Roche Injectable composition for the sustained release of biologically active compounds
TW402506B (en) * 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
IS1796B (is) * 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
US5506203C1 (en) * 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
US5747445A (en) * 1993-06-24 1998-05-05 Astra Aktiebolag Therapeutic preparation for inhalation
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US6051256A (en) 1994-03-07 2000-04-18 Inhale Therapeutic Systems Dispersible macromolecule compositions and methods for their preparation and use
ES2218543T3 (es) 1994-03-07 2004-11-16 Nektar Therapeutics Procedimiento y preparacion para la administracion de insulina por via pulmonar.
US6165976A (en) * 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
DE19536246A1 (de) * 1994-09-30 1996-04-04 Juergen Dr Regenold Pharmazeutische Zusammensetzung
CZ288146B6 (en) 1994-12-22 2001-05-16 Astra Ab Pharmaceutical aerosol preparation, process of its preparation and use
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
SE9404468D0 (sv) * 1994-12-22 1994-12-22 Astra Ab Powder formulations
US5869602A (en) 1995-03-17 1999-02-09 Novo Nordisk A/S Peptide derivatives
US5780014A (en) * 1995-04-14 1998-07-14 Inhale Therapeutic Systems Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin
US5653987A (en) * 1995-05-16 1997-08-05 Modi; Pankaj Liquid formulations for proteinic pharmaceuticals
US5856446A (en) * 1995-07-07 1999-01-05 Autoimmune Inc. Method of treating rheumatoid arthritis with low dose type II collagen
JPH11292787A (ja) * 1995-08-15 1999-10-26 Asahi Chem Ind Co Ltd 生理活性ペプチドを含有する経粘膜投与製剤
US20020052310A1 (en) 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US6652837B1 (en) 1996-05-24 2003-11-25 Massachusetts Institute Of Technology Preparation of novel particles for inhalation
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US5985309A (en) * 1996-05-24 1999-11-16 Massachusetts Institute Of Technology Preparation of particles for inhalation
EP1826216A1 (en) 1996-08-30 2007-08-29 Novo Nordisk A/S Glp-1 derivatives
US7052678B2 (en) 1997-09-15 2006-05-30 Massachusetts Institute Of Technology Particles for inhalation having sustained release properties
RU2155604C2 (ru) * 1998-01-29 2000-09-10 МНПП "Экоспектр" Лецитиновый органогель
US6017545A (en) * 1998-02-10 2000-01-25 Modi; Pankaj Mixed micellar delivery system and method of preparation
DE69942305D1 (de) 1998-02-27 2010-06-10 Novo Nordisk As Derivate von glp-1 und exendin mit verlängertem wirkdauer-profil
DE69942307D1 (de) 1998-02-27 2010-06-10 Novo Nordisk As N-terminal veränderte glp-1 abkömmlinge
EP1060191B1 (en) 1998-02-27 2010-04-28 Novo Nordisk A/S Derivatives of glp-1 analogs
TWI243687B (en) 1998-04-21 2005-11-21 Teijin Ltd Pharmaceutical composition for application to mucosa
ATE251465T1 (de) 1998-07-31 2003-10-15 Novo Nordisk As In-vitro stimulation von beta zellen vermehrung
US6956021B1 (en) 1998-08-25 2005-10-18 Advanced Inhalation Research, Inc. Stable spray-dried protein formulations
US6290987B1 (en) 1998-09-27 2001-09-18 Generex Pharmaceuticals, Inc. Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids
US6271200B1 (en) 1998-12-21 2001-08-07 Generex Pharmaceuticals Inc. Proteinic drug delivery system using aerosolized membrane-mimetic amphiphiles
US7087215B2 (en) 1998-12-21 2006-08-08 Generex Pharmaceuticals Incorporated Methods of administering and enhancing absorption of pharmaceutical agents
US6849263B2 (en) 1998-12-21 2005-02-01 Generex Pharmaceutical Incorporated Pharmaceutical compositions for buccal delivery of pain relief medications
US6436367B1 (en) 1998-12-21 2002-08-20 Generex Pharmaceuticals Inc. Aerosol formulations for buccal and pulmonary application
US6540982B1 (en) * 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
ATE309818T1 (de) 2000-03-08 2005-12-15 Novo Nordisk As Senkung des serum cholesterols
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
JP2005504715A (ja) 2000-12-29 2005-02-17 アドバンスト インハレーション リサーチ，インコーポレイテッド 持続放出特性を有する吸入用粒子
US7244703B2 (en) 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
CA2451839C (en) * 2001-06-22 2013-08-06 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions comprising peptides and permeation enhancers
ES2415654T3 (es) 2001-11-20 2013-07-26 Civitas Therapeutics, Inc. Composiciones particuladas mejoradas para suministro pulmonar
GB0205327D0 (en) * 2002-03-06 2002-04-17 Glaxo Group Ltd compounds
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
EP1660531A2 (en) 2003-08-05 2006-05-31 Novo Nordisk A/S Novel insulin derivatives
SI2107069T1 (sl) 2003-08-05 2013-04-30 Novo Nordisk A/S Novi inzulinski derivati
WO2005027978A2 (en) 2003-09-19 2005-03-31 Novo Nordisk A/S Albumin-binding derivatives of therapeutic peptides
WO2005092301A1 (en) 2004-03-26 2005-10-06 Universita' Degli Studi Di Parma Insulin highly respirable microparticles
CN1299770C (zh) * 2004-05-31 2007-02-14 刘近周 多功能鼻腔和鼻窦洁疗液
SG157423A1 (en) 2004-12-02 2009-12-29 Domantis Ltd Bispecific domain antibodies targeting serum albumin and glp-1 or pyy
EP2256130B1 (en) 2005-02-02 2013-09-25 Novo Nordisk A/S Novel insulin derivatives
EP1846447B1 (en) 2005-02-02 2013-08-21 Novo Nordisk A/S Insulin derivatives
JP5202338B2 (ja) 2006-02-27 2013-06-05 ノボ・ノルデイスク・エー／エス 新規インシュリン誘導体
RU2451029C2 (ru) 2006-05-09 2012-05-20 Ново Нордиск А/С Производное инсулина
ES2553154T3 (es) 2006-05-09 2015-12-04 Novo Nordisk A/S Derivado de la insulina
EP2170945A1 (en) 2007-07-16 2010-04-07 Novo Nordisk A/S Protease stabilized, pegylated insulin analogues
JP5730569B2 (ja) 2007-08-15 2015-06-10 ノボ・ノルデイスク・エー／エス アシル及びアルキレングリコール部分を有するインスリンアナログ
CN101784563B (zh) 2007-08-15 2015-02-04 诺沃-诺迪斯克有限公司 具有包括含亚烷基二醇的氨基酸的重复单位的酰基部分的胰岛素
EP2910569B1 (en) 2008-03-18 2016-10-05 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
JP2011517561A (ja) 2008-03-31 2011-06-16 グラクソ グループ リミテッド 薬物融合体および複合体
US9242011B2 (en) 2008-04-01 2016-01-26 Novo Nordisk A/S Insulin albumin conjugates
US8551454B2 (en) 2009-03-13 2013-10-08 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
US8277781B2 (en) 2009-03-13 2012-10-02 Luitpold Pharmaceuticals, Inc. Device for intranasal administration
EA021146B1 (ru) 2009-03-27 2015-04-30 Глаксо Груп Лимитед Продукты слияния и конъюгаты лекарственных средств
KR20120092611A (ko) 2009-09-30 2012-08-21 글락소 그룹 리미티드 연장된 반감기를 갖는 약물 융합체 및 컨쥬게이트
AU2011322495A1 (en) 2010-10-27 2013-04-11 Novo Nordisk A/S Treating diabetes melitus using insulin injections administered with varying injection intervals
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
WO2012136790A1 (en) 2011-04-07 2012-10-11 Glaxo Group Limited Compositions comprising fusion proteins or conjugates with an improved half -life
WO2012136792A2 (en) 2011-04-07 2012-10-11 Glaxo Group Limited Cck compositions
US20150038417A1 (en) 2011-12-09 2015-02-05 Novo Nordisk A/S GLP-1 Agonists
WO2013164375A1 (en) 2012-05-01 2013-11-07 Novo Nordisk A/S Pharmaceutical composition
WO2014093688A1 (en) 2012-12-12 2014-06-19 1Massachusetts Institute Of Technology Compositions and methods for functional nucleic acid delivery
US9867869B2 (en) 2012-12-12 2018-01-16 Massachusetts Institute Of Technology Insulin derivatives for diabetes treatment
CN105934257B (zh) 2013-12-06 2020-10-09 韩捷 用于含氮和羟基的药物的生物可逆引入基团
EP3258919B2 (en) * 2015-02-17 2022-11-09 Eli Lilly and Company Nasal powder formulation for treatment of hypoglycemia
US20210369799A1 (en) 2018-11-04 2021-12-02 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nasal compositions and methods

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3594476A (en) * 1969-05-12 1971-07-20 Massachusetts Inst Technology Submicron aqueous aerosols containing lecithin
GB1527605A (en) * 1975-08-20 1978-10-04 Takeda Chemical Industries Ltd Insulin preparation for intranasal administration
NL193099C (nl) * 1981-10-30 1998-11-03 Novo Industri As Gestabiliseerde insuline-oplossing.
DE3228629A1 (de) * 1982-07-31 1984-02-02 Reifenrath, Rainer Richard Otto, Dr., 3104 Unterlüß Pharmazeutisches erzeugnis zur behandlung der atemwege und verfahren zu seiner herstellung
DE3323389A1 (de) * 1983-06-29 1985-01-10 B. Braun Melsungen Ag, 3508 Melsungen Auf schleimhaeute des mundes, der nase und/oder des rachens wirkende arzneimittel auf der basis von heparin und tensiden
GB8327330D0 (en) * 1983-10-12 1983-11-16 Parsons W J Membrane analogue emulsions
EP0179904A1 (en) * 1984-05-09 1986-05-07 Medaphore Inc. Oral insulin and a method of making the same
GB8501015D0 (en) * 1985-01-16 1985-02-20 Riker Laboratories Inc Drug
CA1274774A (en) * 1985-04-15 1990-10-02 Kenneth S. Su Method for administering insulin
IT1187743B (it) * 1985-09-26 1987-12-23 Prodotti Formenti Srl Composizioni farmaceutiche a base di destrorfano per applicazione instranasale

Also Published As

Publication number Publication date
PT86370A (en) 1988-01-01
CN1034105C (zh) 1997-02-26
KR890700036A (ko) 1989-03-02
IL84835A (en) 1994-01-25
IL84835A0 (en) 1988-06-30
ES2044957T3 (es) 1994-01-16
PT86370B (pt) 1990-11-20
RU1837869C (ru) 1993-08-30
CS273139B1 (en) 1991-03-12
NO175566B (no) 1994-07-25
CS930487A1 (en) 1990-07-12
NO883627L (no) 1988-08-15
JPH0768149B2 (ja) 1995-07-26
CN87108340A (zh) 1988-07-13
HUT57592A (en) 1991-12-30
FI94024C (fi) 1995-07-10
DE3780925T2 (de) 1992-12-24
FI883783A0 (fi) 1988-08-15
AU1085888A (en) 1988-07-15
MX9203640A (es) 1992-09-01
CA1326210C (en) 1994-01-18
NO883627D0 (no) 1988-08-15
EP0272097B1 (en) 1992-08-05
IE61110B1 (en) 1994-10-05
DE3780925D1 (de) 1992-09-10
FI883783L (fi) 1988-08-15
NZ222907A (en) 1990-08-28
WO1988004556A1 (en) 1988-06-30
IE873408L (en) 1988-06-16
NO175566C (no) 1994-11-02
EP0272097A3 (en) 1988-08-24
FI94024B (fi) 1995-03-31
HU209247B (en) 1994-04-28
JPH01501550A (ja) 1989-06-01
YU228487A (en) 1988-12-31
AU606121B2 (en) 1991-01-31
EP0272097A2 (en) 1988-06-22
ATE79039T1 (de) 1992-08-15
GR3005381T3 (sh) 1993-05-24

Similar Documents

Publication Publication Date Title
YU46978B (sh) Postupak za dobijanje preparata za nazalnu upotrebu
FI83592B (fi) Vaetskeformigt preparat avsett foer oxidationshaorfaerger.
JP3211027B2 (ja) カプサイシン含有外用剤
EP0007595B1 (en) Preparations of clotrimazole and process for preparing same
BR9307700A (pt) Formulação para estabilizar uma composição enzimática lìquida, composição enzimática lìquida estabilizada, método para a preparação de uma composição enzimática lìquida estabilizada e método para estabilizar uma composição enzimática lìquida
US3326808A (en) Antiseptic detergent composition
EP1153595A3 (en) Clear aqueous ceramide composition
CA1202855A (en) Mild antimicrobial detergent composition
JP2001510780A (ja) 高濃度の皮膚軟化剤を含む安定な液体組成物
DE69516687D1 (de) Flüssige zusammensetzung zur behandlung von tissue-papier
ES457745A1 (es) Procedimiento para la preparacion de nuevas fluoracil-resor-cinas sustituidas.
JPH0466844B2 (sh)
EP0081801B1 (en) Liquid detergent composition
CN108403472A (zh) 一种洗涤剂组合物及其应用
YU46020B (sh) Postupak za dobijanje insekticidnog preparata u obliku gela
JPS61210024A (ja) 外用塩酸ニカルジピン製剤
JPH0826962A (ja) 皮膚外用剤組成物
JP2002173694A (ja) 透明洗浄料
US6602513B2 (en) Face pack
JPH04122799A (ja) 洗浄剤組成物
JP5013790B2 (ja) 殺菌剤組成物、並びに該殺菌剤組成物を含有した皮膚外用剤
RU2098081C1 (ru) Бензилбензоат в водно-эмульсионной форме
US4172888A (en) Athlete's foot treatment
YU48388B (sh) Postupak za dobijanje farmaceutske masti koja ne iritira kožu
JP3140513B2 (ja) 外用医薬基剤および外用医薬組成物