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YU46720B - Postupak za dobijanje novih 2-amino-tetrahidro-izohinolinskih derivata - Google Patents

Postupak za dobijanje novih 2-amino-tetrahidro-izohinolinskih derivata

Info

Publication number
YU46720B
YU46720B YU236088A YU236088A YU46720B YU 46720 B YU46720 B YU 46720B YU 236088 A YU236088 A YU 236088A YU 236088 A YU236088 A YU 236088A YU 46720 B YU46720 B YU 46720B
Authority
YU
Yugoslavia
Prior art keywords
general formula
hydrogen
tetrahydro
amino
preparation
Prior art date
Application number
YU236088A
Other languages
English (en)
Other versions
YU236088A (en
Inventor
E. Palosi
D. Korbonits
E. Molnar
J. Szvoboda
L. Harsing
G. Simon
V. Gergely
P. Kormoczi
S. Virag
K. Marmarosi
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Publication of YU236088A publication Critical patent/YU236088A/xx
Publication of YU46720B publication Critical patent/YU46720B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE NOVIH 2-AMINO-TETRAHIDRO-IZOHINOLINSKIH DERIVATA, opšte formule I: gde R je vodonik ili hlor, R1 i R2 su vodonik ili metoksi, R3 i R4 su vodonik ili metil, naznačen time, što obuhvata reakciju 2-amino-tetrahidro-izohinolinskog derivata opšte formule II: u kojoj R1, R2, R3 i R4 imaju napred data značenja, sa derivatom karboksilne kiseline opšte formule III: gde X je hlor, R5 I R6 predstavljaju vodonik ili zajedno grade CHN(CH3)2 u prisustvu rastvarača i sredstva za vezivanje kiseline na temperaturi od -20 do 100 В°C, radi dobivanja jedinjenja opšte formule I kada R5 i R6 su vodonik ili jedinjenja opšte formule Ia gde R, R1, R2, R3 i R4 su kao što je dato napred, kada R5 i R6 zajedno grade CH(CH3)2 i zaštitna grupa se odvaja u alkalnoj sredini na temperaturi 20-80 В°C
YU236088A 1987-12-30 1988-12-27 Postupak za dobijanje novih 2-amino-tetrahidro-izohinolinskih derivata YU46720B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU876132A HU198458B (en) 1987-12-30 1987-12-30 Process for producing 2-aminoisoquinoline derivatives and pharmaceutical compositions comprising these compounds

Publications (2)

Publication Number Publication Date
YU236088A YU236088A (en) 1990-02-28
YU46720B true YU46720B (sh) 1994-04-05

Family

ID=10971251

Family Applications (1)

Application Number Title Priority Date Filing Date
YU236088A YU46720B (sh) 1987-12-30 1988-12-27 Postupak za dobijanje novih 2-amino-tetrahidro-izohinolinskih derivata

Country Status (24)

Country Link
US (1) US4940716A (sh)
EP (1) EP0324184B1 (sh)
JP (1) JPH01213266A (sh)
CN (1) CN1022917C (sh)
AT (1) ATE112268T1 (sh)
AU (1) AU635463B2 (sh)
CA (1) CA1329209C (sh)
CS (1) CS274495B2 (sh)
DD (1) DD283382A5 (sh)
DE (1) DE3851697D1 (sh)
ES (1) ES2059485T3 (sh)
FI (1) FI90536C (sh)
HR (1) HRP920564A2 (sh)
HU (1) HU198458B (sh)
IE (1) IE883879L (sh)
IL (1) IL88639A (sh)
NO (1) NO176177C (sh)
NZ (1) NZ227416A (sh)
PH (1) PH25608A (sh)
PL (1) PL155977B1 (sh)
PT (1) PT89356B (sh)
SU (2) SU1676444A3 (sh)
YU (1) YU46720B (sh)
ZA (1) ZA889285B (sh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005002130A1 (de) * 2005-01-17 2006-07-27 Sanofi-Aventis Deutschland Gmbh Substituierte N-Aminomethylensulfonamide, ihre Herstellung und Verwendung als Arzneimittel

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3037984A (en) * 1960-01-27 1962-06-05 Lakeside Lab Inc Derivatives of n-amino-1, 2, 3, 4-tetrahydroisoquinoline
JPH01503233A (ja) * 1986-10-28 1989-11-02 スミス・クライン・アンド・フレンチ・ラボラトリース・リミテッド 製薬活性化合物

Also Published As

Publication number Publication date
PT89356A (pt) 1989-12-29
SU1676444A3 (ru) 1991-09-07
HRP920564A2 (hr) 1994-04-30
AU635463B2 (en) 1993-03-18
ZA889285B (en) 1989-09-27
PT89356B (pt) 1993-09-30
NO176177B (no) 1994-11-07
ES2059485T3 (es) 1994-11-16
CS274495B2 (en) 1991-04-11
NO885811L (no) 1989-07-03
FI886046A (fi) 1989-07-01
HU198458B (en) 1989-10-30
PL155977B1 (en) 1992-01-31
YU236088A (en) 1990-02-28
IL88639A (en) 1992-11-15
SU1705287A1 (ru) 1992-01-15
EP0324184B1 (de) 1994-09-28
ATE112268T1 (de) 1994-10-15
CA1329209C (en) 1994-05-03
PH25608A (en) 1991-08-08
DE3851697D1 (de) 1994-11-03
NZ227416A (en) 1990-11-27
CN1035502A (zh) 1989-09-13
AU2762888A (en) 1989-07-06
EP0324184A3 (en) 1990-05-02
FI90536B (fi) 1993-11-15
PL276887A1 (en) 1989-09-04
IE883879L (en) 1989-06-30
CS902588A2 (en) 1990-09-12
JPH01213266A (ja) 1989-08-28
US4940716A (en) 1990-07-10
NO176177C (no) 1995-02-15
NO885811D0 (no) 1988-12-29
HUT48599A (en) 1989-06-28
FI90536C (fi) 1994-02-25
CN1022917C (zh) 1993-12-01
EP0324184A2 (de) 1989-07-19
IL88639A0 (en) 1989-07-31
DD283382A5 (de) 1990-10-10

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