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YU137291A - Postupak za dobijanje hinolinskih derivata - Google Patents

Postupak za dobijanje hinolinskih derivata

Info

Publication number
YU137291A
YU137291A YU137291A YU137291A YU137291A YU 137291 A YU137291 A YU 137291A YU 137291 A YU137291 A YU 137291A YU 137291 A YU137291 A YU 137291A YU 137291 A YU137291 A YU 137291A
Authority
YU
Yugoslavia
Prior art keywords
group
methyl
amino
procedure
quinoline derivatives
Prior art date
Application number
YU137291A
Other languages
English (en)
Inventor
J. Matsumoto
T. Miyamoto
H. Egawa
S. Nanamuro
Original Assignee
Dainippon Pharmaceutical Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co. Ltd. filed Critical Dainippon Pharmaceutical Co. Ltd.
Publication of YU137291A publication Critical patent/YU137291A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Dat je postupak za dobijanje hinolinskog derivata opšte formule gde Z je amino grupa ili atom halogena; R1 je H, metil ili etil grupa; R2 je H, metil ili fluorometil grupa; R3 i R4 su isti ili različiti i svaki je H ili metil grupa; Y je H ili C1-5 alkil grupa. Postupak obuhvata uklanjanje zaštitne grupe jedinjenja opšte formule gde Z' je amino grupa, atom halogena ili zaštitna amino grupa; R'1 je H, metil ili etil grupa ili zaštitna grupa. Ostali susptituenti imaju napred data značenja. Postupak dalje obuhvata hidrolizu dobivenog estra radi gradjenja karboksilne kiseline i po izboru prevodjenje tako dobivene kiseline u svoju farmaceutski prihvatljivu so.
YU137291A 1985-10-29 1991-08-08 Postupak za dobijanje hinolinskih derivata YU137291A (sh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP24225785 1985-10-29
JP28532385 1985-12-17
JP3262786 1986-02-17

Publications (1)

Publication Number Publication Date
YU137291A true YU137291A (sh) 1994-01-20

Family

ID=27287785

Family Applications (3)

Application Number Title Priority Date Filing Date
YU183586A YU46414B (sh) 1985-10-29 1986-10-29 Postupak za dobivanje hinolinskih derivata
YU137291A YU137291A (sh) 1985-10-29 1991-08-08 Postupak za dobijanje hinolinskih derivata
YU137191A YU137191A (sh) 1985-10-29 1991-08-08 Postupak za dobijanje hinolinskih derivata

Family Applications Before (1)

Application Number Title Priority Date Filing Date
YU183586A YU46414B (sh) 1985-10-29 1986-10-29 Postupak za dobivanje hinolinskih derivata

Family Applications After (1)

Application Number Title Priority Date Filing Date
YU137191A YU137191A (sh) 1985-10-29 1991-08-08 Postupak za dobijanje hinolinskih derivata

Country Status (26)

Country Link
US (1) US4795751A (sh)
EP (2) EP0221463B1 (sh)
JP (2) JPS62277362A (sh)
KR (1) KR910006806B1 (sh)
CN (1) CN1009930B (sh)
AR (3) AR242031A1 (sh)
AT (2) ATE66210T1 (sh)
AU (1) AU594983B2 (sh)
CA (1) CA1340402C (sh)
DE (3) DE3680859D1 (sh)
DK (2) DK170593B1 (sh)
ES (2) ES2029786T3 (sh)
FI (1) FI87457C (sh)
GE (1) GEP19960467B (sh)
GR (1) GR3002475T3 (sh)
HU (1) HU200452B (sh)
IL (1) IL80404A (sh)
LU (2) LU88596I2 (sh)
MY (1) MY100574A (sh)
NL (2) NL970020I2 (sh)
NO (1) NO170726C (sh)
NZ (1) NZ218089A (sh)
PH (1) PH22862A (sh)
PT (1) PT83643B (sh)
SU (2) SU1635898A3 (sh)
YU (3) YU46414B (sh)

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US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US5164392A (en) * 1987-10-16 1992-11-17 Dainippon Pharmaceutical Co., Ltd. Quinoline derivatives and antibacterial agent containing them
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AU609974B2 (en) * 1988-05-18 1991-05-09 Warner-Lambert Company Improved process for the preparation of 5-amino-7- (substituted amino)-quinoline-3-carboxylic acids
JPH0674261B2 (ja) * 1988-06-21 1994-09-21 塩野義製薬株式会社 キノロンカルボン酸誘導体
JP2709604B2 (ja) * 1988-06-29 1998-02-04 大日本製薬株式会社 マイコプラズマ汚染の防止または除去
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
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DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
US5342846A (en) * 1990-12-05 1994-08-30 Synphar Laboratories, Inc. 7-substituted-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid compounds and 7-(substituted triazolyl pyrrolidin-1-yl) 4-oxoquinoline-3-carboxylic acid derivatives useful as antibacterial agents
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CN1038326C (zh) * 1993-07-20 1998-05-13 爱斯制药株式会社 5－氨基喹诺酮羧酸衍生物及其含有该衍生物作为活性成分的抗菌剂
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AU757777B2 (en) 1998-12-04 2003-03-06 Influx, Inc. Inhibitors of multidrug transporters
CN1343128B (zh) 1999-03-17 2010-04-21 第一制药株式会社 药物组合物
CN1091103C (zh) * 1999-04-02 2002-09-18 中国科学院上海药物研究所 一类喹诺酮类化合物及它的制备和其用途
US6957105B2 (en) * 2002-03-26 2005-10-18 Cardiac Pacemakers, Inc. Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals
KR100519158B1 (ko) * 2002-12-21 2005-10-06 주식회사유한양행 퀴놀론 카르복실레이트 유도체의 제조방법
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070196398A1 (en) * 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone fatty acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions
US20080139574A1 (en) 2006-11-30 2008-06-12 Cadila Healthcare Limited Novel quinoline derivatives
EP3641747B1 (en) 2017-06-22 2023-09-06 Cipla Limited Par-4 secretagogues for the treatment of cancer
CN110724097B (zh) * 2019-11-11 2021-03-09 山东畜牧兽医职业学院 一种治疗耐药性微生物菌的化合物及其制备方法

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US4668680A (en) * 1985-12-12 1987-05-26 Warner-Lambert Company 5-amino-6,8-difluoroquinolones as antibacterial agents
US4977154A (en) * 1985-12-12 1990-12-11 Warner-Lambert Company 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents
EP0230053A3 (en) * 1986-01-17 1988-03-30 American Cyanamid Company 7-(substituted)piperazinyl-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
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Also Published As

Publication number Publication date
DE10075028I1 (de) 2000-12-14
LU90621I2 (fr) 2000-10-09
NL970020I2 (nl) 1998-01-05
LU88596I2 (fr) 1995-07-10
NL970020I1 (nl) 1997-08-01
CN86107491A (zh) 1987-04-29
KR910006806B1 (ko) 1991-09-02
DE3650018T2 (de) 1995-01-05
DK170774B1 (da) 1996-01-15
JPH0541633B2 (sh) 1993-06-24
NO170726C (no) 1992-11-25
MY100574A (en) 1990-12-15
AU6427786A (en) 1987-04-30
ES2029786T3 (es) 1992-10-01
DE3650018D1 (de) 1994-09-08
JPH0714918B2 (ja) 1995-02-22
CN1009930B (zh) 1990-10-10
FI87457B (fi) 1992-09-30
GR3002475T3 (en) 1992-12-30
AR243178A1 (es) 1993-07-30
KR870004019A (ko) 1987-05-06
HUT43839A (en) 1987-12-28
ATE66210T1 (de) 1991-08-15
NZ218089A (en) 1989-03-29
JPH0543551A (ja) 1993-02-23
FI87457C (fi) 1993-01-11
SU1635898A3 (ru) 1991-03-15
AU594983B2 (en) 1990-03-22
YU137191A (sh) 1994-01-20
DK514586D0 (da) 1986-10-28
NO864247D0 (no) 1986-10-23
NL300014I2 (nl) 2001-02-01
NO170726B (no) 1992-08-17
DE10075028I2 (de) 2004-01-29
NO864247L (no) 1987-04-30
YU46414B (sh) 1993-10-20
AR242031A1 (es) 1993-02-26
DE3680859D1 (de) 1991-09-19
GEP19960467B (en) 1996-05-27
DK25992A (da) 1992-02-28
PH22862A (en) 1989-01-19
EP0375658A1 (en) 1990-06-27
ATE109472T1 (de) 1994-08-15
ES2057197T3 (es) 1994-10-16
US4795751A (en) 1989-01-03
NL300014I1 (nl) 2000-10-02
SU1598873A3 (ru) 1990-10-07
IL80404A (en) 1990-06-10
DK514586A (da) 1987-04-30
YU183586A (en) 1988-04-30
PT83643B (pt) 1988-10-14
HU200452B (en) 1990-06-28
EP0221463A2 (en) 1987-05-13
FI864299A0 (fi) 1986-10-23
DK25992D0 (da) 1992-02-28
FI864299A (fi) 1987-04-30
DK170593B1 (da) 1995-11-06
PT83643A (en) 1986-11-01
AR243520A1 (es) 1993-08-31
EP0221463B1 (en) 1991-08-14
IL80404A0 (en) 1987-01-30
EP0375658B1 (en) 1994-08-03
JPS62277362A (ja) 1987-12-02
EP0221463A3 (en) 1987-12-02
CA1340402C (en) 1999-02-23

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