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YU16102A - Kalcijum kompleks etilendiaminskih derivata koji sadrže fosfor - Google Patents

Kalcijum kompleks etilendiaminskih derivata koji sadrže fosfor

Info

Publication number
YU16102A
YU16102A YU16102A YUP16102A YU16102A YU 16102 A YU16102 A YU 16102A YU 16102 A YU16102 A YU 16102A YU P16102 A YUP16102 A YU P16102A YU 16102 A YU16102 A YU 16102A
Authority
YU
Yugoslavia
Prior art keywords
kappa
ethylendiamine
derivatives
calcium complex
phosphorus containing
Prior art date
Application number
YU16102A
Other languages
English (en)
Inventor
Johannes Platzek
Ulrich Niedeballa
Gunter Michl
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7922563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU16102(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE1999144893 external-priority patent/DE19944893C2/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of YU16102A publication Critical patent/YU16102A/sh
Publication of RS50125B publication Critical patent/RS50125B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
  • Cosmetics (AREA)

Abstract

Opisan je pronalazak koji se odnosi na kalcijum kompleks [[(4R)-4-[bis[(karboksi-.kapa.O)metil]-amino-.kapa.N]-6,9-bis[(karboksi-.kapa.O)metil]-1-[(4,4-difenilcikloheksil)oksi]-1-hidroksi-2-oksa-6,9-diaza-1-fosfaundekan-11-ilik-kiselina-.kapa.N6..kapa.N9,.kapa.0,11]-1-oksidato(6-)]-, tetrahidrogen (MS-325), ili njegove soli sa fiziološki kompatibilnim katjonom, u svakom slučaju u suštini bez Gd-MS-325.[The invention relates to the calcium complex of[[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O) methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.kappa.N9,.kappa.011]1- oxidato(6-)]-, tetrahydrogen (MS-325) and its salts, pharmaceutical agents that contain these complexes for the production of agents for the reduction of effects that are caused by heavy metals as well as processes for their production.
YUP-161/02A 1999-09-09 2000-09-06 Kalcijum kompleks etilendiaminskih derivata koji sadrže fosfor RS50125B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1999144893 DE19944893C2 (de) 1999-09-09 1999-09-09 Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-. kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6, .kappa.N9,.kappa.O11]1-oxidato(6-)]-, hexahydrogen, dessen Salze und diese Komplexe enthaltende pharmazeutische Mittel

Publications (2)

Publication Number Publication Date
YU16102A true YU16102A (sh) 2005-06-10
RS50125B RS50125B (sr) 2009-03-25

Family

ID=7922563

Country Status (30)

Country Link
EP (1) EP1210353B1 (sh)
JP (1) JP2003508537A (sh)
KR (1) KR100650090B1 (sh)
CN (1) CN100341883C (sh)
AT (1) ATE245159T1 (sh)
AU (1) AU783982B2 (sh)
BG (1) BG65280B1 (sh)
BR (1) BR0013871A (sh)
CA (1) CA2380766C (sh)
CZ (1) CZ2002834A3 (sh)
DE (2) DE19964224B4 (sh)
DK (1) DK1210353T3 (sh)
EE (1) EE05106B1 (sh)
ES (1) ES2202178T3 (sh)
HK (1) HK1050202A1 (sh)
HR (1) HRP20020302B1 (sh)
HU (1) HUP0202873A3 (sh)
IL (1) IL148563A (sh)
MX (1) MXPA02001583A (sh)
NO (1) NO20021167L (sh)
NZ (1) NZ517708A (sh)
PL (1) PL354749A1 (sh)
PT (1) PT1210353E (sh)
RS (1) RS50125B (sh)
RU (1) RU2247727C2 (sh)
SK (1) SK3242002A3 (sh)
TW (1) TWI263641B (sh)
UA (1) UA74165C2 (sh)
WO (1) WO2001018011A1 (sh)
ZA (1) ZA200202742B (sh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201514188A (zh) 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
CN114845990A (zh) 2019-12-20 2022-08-02 伯拉考成像股份公司 钙bopta配合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
TW319763B (sh) * 1995-02-01 1997-11-11 Epix Medical Inc
US5919967A (en) * 1997-04-11 1999-07-06 Epix Medical, Inc. Process for synthesizing phosphodiesters

Also Published As

Publication number Publication date
HUP0202873A3 (en) 2003-12-29
RS50125B (sr) 2009-03-25
EP1210353B1 (en) 2003-07-16
HRP20020302B1 (en) 2005-08-31
IL148563A (en) 2005-12-18
UA74165C2 (uk) 2005-11-15
NO20021167D0 (no) 2002-03-08
PT1210353E (pt) 2003-11-28
CN100341883C (zh) 2007-10-10
TWI263641B (en) 2006-10-11
HRP20020302A2 (en) 2004-02-29
MXPA02001583A (es) 2004-04-05
IL148563A0 (en) 2002-09-12
HUP0202873A2 (hu) 2002-12-28
NZ517708A (en) 2003-10-31
ZA200202742B (en) 2003-09-23
AU7774900A (en) 2001-04-10
DE19964224A1 (de) 2001-06-28
DE60003931D1 (de) 2003-08-21
EP1210353A1 (en) 2002-06-05
HK1050202A1 (en) 2003-06-13
ATE245159T1 (de) 2003-08-15
ES2202178T3 (es) 2004-04-01
CA2380766C (en) 2008-11-25
BG65280B1 (bg) 2007-11-30
KR20020025256A (ko) 2002-04-03
BR0013871A (pt) 2002-05-21
CZ2002834A3 (cs) 2002-07-17
PL354749A1 (en) 2004-02-23
BG106488A (en) 2002-10-31
AU783982B2 (en) 2006-01-12
NO20021167L (no) 2002-03-08
DE60003931T2 (de) 2004-05-27
DE19964224B4 (de) 2005-09-01
EE05106B1 (et) 2008-12-15
DK1210353T3 (da) 2003-10-27
WO2001018011A1 (en) 2001-03-15
EE200200090A (et) 2003-04-15
CA2380766A1 (en) 2001-03-15
JP2003508537A (ja) 2003-03-04
SK3242002A3 (en) 2002-10-08
KR100650090B1 (ko) 2006-11-27
CN1373765A (zh) 2002-10-09
WO2001018011A9 (en) 2002-09-06
RU2247727C2 (ru) 2005-03-10

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