Nothing Special   »   [go: up one dir, main page]

WO2010030132A3 - 아데포비어 디피복실의 정제방법 - Google Patents

아데포비어 디피복실의 정제방법 Download PDF

Info

Publication number
WO2010030132A3
WO2010030132A3 PCT/KR2009/005150 KR2009005150W WO2010030132A3 WO 2010030132 A3 WO2010030132 A3 WO 2010030132A3 KR 2009005150 W KR2009005150 W KR 2009005150W WO 2010030132 A3 WO2010030132 A3 WO 2010030132A3
Authority
WO
WIPO (PCT)
Prior art keywords
adefovir dipivoxil
purified
chemical formula
solution
present
Prior art date
Application number
PCT/KR2009/005150
Other languages
English (en)
French (fr)
Other versions
WO2010030132A2 (ko
WO2010030132A9 (ko
Inventor
조일환
윤명식
최광도
이용택
이시범
방성철
이민경
오다원
Original Assignee
씨제이제일제당 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 씨제이제일제당 주식회사 filed Critical 씨제이제일제당 주식회사
Priority to US13/063,449 priority Critical patent/US20110207928A1/en
Priority to JP2011526814A priority patent/JP5390617B2/ja
Priority to CN200980134900.2A priority patent/CN102143967B/zh
Priority to EP09813254A priority patent/EP2327708A4/en
Publication of WO2010030132A2 publication Critical patent/WO2010030132A2/ko
Publication of WO2010030132A3 publication Critical patent/WO2010030132A3/ko
Publication of WO2010030132A9 publication Critical patent/WO2010030132A9/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/025—Purification; Separation; Stabilisation; Desodorisation of organo-phosphorus compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 화학식 1의 아데포비어 디피복실의 새로운 정제 방법에 관한 것으로, 본 발명에 따른 정제 방법은, 합성을 통하여 제조된 부산물이 포함된 불순한 상태의 아데포비어 디피복실, 이의 염 또는 이의 복합체를, 물 또는 물을 포함한 혼합용매에 용해시키는 단계, 아데포비어 디피복실 용액을 역상컬럼으로 통해 정제하는 단계 및 정제된 아데포비어 디피복실 용액에 염기를 첨가하고 유기용매로 추출하는 단계를 이용하여 화학식 1로 표시되는 고순도의 아데포비어 디피복실을 정제하는 방법을 포함한다. 또한 본 발명은 상기 방법을 사용하여 정제된 화학식 1로 표시되는 고순도의 아데포비어 디피복실 용액에서 용매를 제거하여 무정형의 아데포비어 디피복실을 제조하는 방법을 포함한다.
PCT/KR2009/005150 2008-09-11 2009-09-10 아데포비어 디피복실의 정제방법 WO2010030132A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US13/063,449 US20110207928A1 (en) 2008-09-11 2009-09-10 Purification method for adefovir dipivoxil
JP2011526814A JP5390617B2 (ja) 2008-09-11 2009-09-10 アデホビルジピボキシルの精製方法
CN200980134900.2A CN102143967B (zh) 2008-09-11 2009-09-10 阿德福韦酯的纯化方法
EP09813254A EP2327708A4 (en) 2008-09-11 2009-09-10 PROCESS FOR PURIFYING ADEFOVIR DIPIVOXIL

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2008-0089907 2008-09-11
KR20080089907 2008-09-11
KR1020090001395A KR20100031045A (ko) 2008-09-11 2009-01-08 아데포비어 디피복실의 정제방법
KR10-2009-0001395 2009-01-08

Publications (3)

Publication Number Publication Date
WO2010030132A2 WO2010030132A2 (ko) 2010-03-18
WO2010030132A3 true WO2010030132A3 (ko) 2010-06-10
WO2010030132A9 WO2010030132A9 (ko) 2010-08-05

Family

ID=42180843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005150 WO2010030132A2 (ko) 2008-09-11 2009-09-10 아데포비어 디피복실의 정제방법

Country Status (7)

Country Link
US (1) US20110207928A1 (ko)
EP (1) EP2327708A4 (ko)
JP (2) JP5390617B2 (ko)
KR (2) KR20100031045A (ko)
CN (1) CN102143967B (ko)
TW (1) TWI372761B (ko)
WO (1) WO2010030132A2 (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20071594A1 (it) * 2007-08-02 2009-02-03 Solmag Spa Forma cristallina monoidrata di adefovir dipivoxil
KR20100031045A (ko) * 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법
KR101247653B1 (ko) * 2010-11-08 2013-04-01 (주) 성운파마코피아 아데포비어 디피복실 제조방법
US8969588B2 (en) * 2012-06-05 2015-03-03 Gilead Pharmasset Llc Solid forms of an antiviral compound
CN103880884A (zh) * 2014-03-21 2014-06-25 浙江苏泊尔制药有限公司 一种高纯度富马酸泰诺福韦酯的制备方法
TWI609745B (zh) * 2015-07-02 2018-01-01 嘉新精密有限公司 側向夾持的彈性定位塊結構
CN105294762A (zh) * 2015-11-13 2016-02-03 中国药科大学 阿德福韦酯杂质的制备方法
CN106167503B (zh) * 2016-07-07 2018-06-22 福建广生堂药业股份有限公司 一种阿德福韦酯羟甲基杂质的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663159A (en) * 1990-09-14 1997-09-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200200117T2 (tr) 1997-07-25 2002-06-21 Gilead Sciences, Inc. Nükleotid analog kompozisyonlar
ZA986614B (en) * 1997-07-25 1999-01-27 Gilead Sciences Nucleotide analog composition
TWI230618B (en) 1998-12-15 2005-04-11 Gilead Sciences Inc Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same
CN1935818B (zh) * 2006-09-22 2011-11-09 闫敬武 阿德福韦酯新晶态、晶态组合物、制备方法及应用
KR20100031045A (ko) * 2008-09-11 2010-03-19 씨제이제일제당 (주) 아데포비어 디피복실의 정제방법
CN102149715A (zh) * 2008-09-17 2011-08-10 Cj第一制糖株式会社 肝适能的稳定化固态分散物及其制备方法
KR20100032803A (ko) * 2008-09-18 2010-03-26 씨제이제일제당 (주) 아데포비어디피복실의 개선된 제조방법

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663159A (en) * 1990-09-14 1997-09-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Prodrugs of phosphonates

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HUI-CHANG BI ET AL: "Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to pharmacokinetic study", RAPID COMMUNACATIONS IN MASS SEPCTROMETRY, vol. 19, no. 20, 2005, pages 2911 - 2917, XP002658318 *

Also Published As

Publication number Publication date
KR20100031085A (ko) 2010-03-19
EP2327708A2 (en) 2011-06-01
JP2014114271A (ja) 2014-06-26
KR100970434B1 (ko) 2010-07-15
TWI372761B (en) 2012-09-21
WO2010030132A2 (ko) 2010-03-18
CN102143967A (zh) 2011-08-03
JP5390617B2 (ja) 2014-01-15
KR20100031045A (ko) 2010-03-19
US20110207928A1 (en) 2011-08-25
JP2012512137A (ja) 2012-05-31
WO2010030132A9 (ko) 2010-08-05
CN102143967B (zh) 2015-02-04
EP2327708A4 (en) 2011-11-30
TW201016713A (en) 2010-05-01

Similar Documents

Publication Publication Date Title
WO2010030132A3 (ko) 아데포비어 디피복실의 정제방법
EA201201179A1 (ru) Способ получения изоксазолиновых производных
WO2012015541A3 (en) Process for the production of para-xylene
WO2007061717A3 (en) Methods for isolating propargylated aminoindans
WO2008062460A3 (en) Crystalline forms of pregabalin
WO2011071314A3 (en) Processes for preparing crystalline forms a and b of ilaprazole and process for converting the crystalline forms
WO2009134531A3 (en) Total synthesis of salinosporamide a and analogs thereof
WO2009141091A8 (de) Neue [f-18] -markierte l-glutaminsäure- und l-glutaminderivate (i), ihre verwendung sowie verfahren zu ihrer herstellung
WO2008033229A3 (en) A method of making porous crystalline materials
WO2013043009A3 (ko) 1-팔미토일-3-아세틸글리세롤의 제조방법 및 이를 이용한 1-팔미토일-2-리놀레오일-3-아세틸글리세롤의 제조방법
WO2009011225A1 (ja) ４－フルオロ－１，３－ジオキソラン－２－オンの製造方法
WO2012031045A3 (en) Phosphonate ester derivatives and methods of synthesis thereof
WO2008015696A3 (en) Process for preparing ciclesonide
WO2008000957A3 (fr) Procédé de préparation d'hydroquinone purifiée
EP2374807A3 (en) An improved process for the isolation of temozolomide
WO2008078589A1 (ja) 放射性ハロゲン標識有機化合物の前駆体化合物の製造方法
EP2172449A3 (en) Process for the purification of Anastrazole
WO2008103367A3 (en) Method for assembling high-purity chemical libraries, proapoptotic compounds discovered by same
WO2007088558A3 (en) A process for purification of valsartan
WO2012164242A8 (en) Process for the preparation of paliperidone
CA2471730A1 (en) Process for preparing and purifying 1,7'-dimethyl-2'-propyl-2,5'-bi-1h-benzimidazole
DE502005010080D1 (de) Ingem chlorid-gehalt
WO2008090819A1 (ja) 二環性プロリン化合物の製造方法
NZ606180A (en) (20r,25s)-2-methylene-19,26-dinor-1α, 25-dihydroxyvitamin d3 in crystalline form
CN104725292A (zh) 一种(s)(-)-氨磺必利的制备方法

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200980134900.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09813254

Country of ref document: EP

Kind code of ref document: A2

WWE Wipo information: entry into national phase

Ref document number: 2009813254

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2011526814

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 13063449

Country of ref document: US