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WO2009008405A1 - トランス－ジベンゾオキセノピロール化合物の製造方法およびその中間体 - Google Patents

トランス－ジベンゾオキセノピロール化合物の製造方法およびその中間体 Download PDF

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Publication number
WO2009008405A1
WO2009008405A1 PCT/JP2008/062279 JP2008062279W WO2009008405A1 WO 2009008405 A1 WO2009008405 A1 WO 2009008405A1 JP 2008062279 W JP2008062279 W JP 2008062279W WO 2009008405 A1 WO2009008405 A1 WO 2009008405A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
dibenzoxenopyrrole
producing trans
intermediate therefor
trans
Prior art date
Application number
PCT/JP2008/062279
Other languages
English (en)
French (fr)
Inventor
Weiqi Wang
Tetsuya Ikemoto
Original Assignee
Sumitomo Chemical Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Company, Limited filed Critical Sumitomo Chemical Company, Limited
Priority to US12/667,654 priority Critical patent/US8288564B2/en
Priority to CA002688459A priority patent/CA2688459A1/en
Priority to EP08777941A priority patent/EP2166012A4/en
Priority to AU2008273375A priority patent/AU2008273375B2/en
Priority to CN2008800197402A priority patent/CN101679449B/zh
Publication of WO2009008405A1 publication Critical patent/WO2009008405A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02—Seven-membered rings
    • C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D313/14—[b,f]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　本発明は、還元、脱離基変換、水添反応およびメチル化をこの順に実施することを特徴とする、トランス－ジベンゾオキセノピロール化合物の製造方法を提供する。本発明の方法によれば、従来の方法より簡便な操作でトランス－ジベンゾオキセノピロール化合物を製造することが可能となる。本発明はまた、上記方法において中間体として得られる新規の化合物およびその製造方法を提供する。
PCT/JP2008/062279 2007-07-06 2008-07-07 トランス－ジベンゾオキセノピロール化合物の製造方法およびその中間体 WO2009008405A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/667,654 US8288564B2 (en) 2007-07-06 2008-07-07 Process for producing trans-dibenzoxenopyrrole compound and intermediate therefor
CA002688459A CA2688459A1 (en) 2007-07-06 2008-07-07 Process for producing trans-dibenzoxenopyrrole compound and intermediate therefor
EP08777941A EP2166012A4 (en) 2007-07-06 2008-07-07 METHOD FOR PRODUCING A TRANSDIBENZOXENPYRROL COMPOUND AND INTERMEDIATE PRODUCT THEREOF
AU2008273375A AU2008273375B2 (en) 2007-07-06 2008-07-07 Process for producing trans-dibenzoxenopyrrole compound and intermediate therefor
CN2008800197402A CN101679449B (zh) 2007-07-06 2008-07-07 反式二苯并*庚因并吡咯化合物的制造方法及其中间体

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-178112 2007-07-06
JP2007178112 2007-07-06
JP2008020889A JP5245428B2 (ja) 2007-07-06 2008-01-31 トランス−ジベンゾオキセノピロール化合物の製造方法およびその中間体
JP2008-020889 2008-01-31

Publications (1)

Publication Number Publication Date
WO2009008405A1 true WO2009008405A1 (ja) 2009-01-15

Family

ID=40437769

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/062279 WO2009008405A1 (ja) 2007-07-06 2008-07-07 トランス－ジベンゾオキセノピロール化合物の製造方法およびその中間体

Country Status (7)

Country Link
US (1) US8288564B2 (ja)
EP (1) EP2166012A4 (ja)
JP (1) JP5245428B2 (ja)
CN (1) CN101679449B (ja)
AU (1) AU2008273375B2 (ja)
CA (1) CA2688459A1 (ja)
WO (1) WO2009008405A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013766A1 (en) 2010-07-29 2012-02-02 Laboratorios Lesvi, S.L. Novel process for the preparation of asenapine
WO2013080069A1 (en) 2011-11-28 2013-06-06 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2468751B1 (en) 2010-12-24 2016-03-16 Medichem, S.A. Processes for the preparation of 5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
PL3338768T3 (pl) 2016-12-20 2020-05-18 Lts Lohmann Therapie-Systeme Ag Transdermalny system terapeutyczny zawierający asenapinę
WO2018115010A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine and polysiloxane or polyisobutylene
JP2020525545A (ja) 2017-06-26 2020-08-27 エルテーエス ローマン テラピー−ジステーメ アーゲー アセナピンおよびシリコーンアクリルハイブリッドポリマーを含有する経皮治療システム
EP3810099A1 (en) 2018-06-20 2021-04-28 LTS Lohmann Therapie-Systeme AG Transdermal therapeutic system containing asenapine
MX2020014286A (es) 2018-06-20 2021-03-25 Lts Lohmann Therapie Systeme Ag Sistema terapeutico transdermico que contiene asenapina.
CN112479940A (zh) * 2020-12-19 2021-03-12 衢州氟瑞医药科技有限公司 一种高纯度氟甲基对甲苯磺酸酯生产工艺

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4969697A (ja) * 1972-11-07 1974-07-05
JPS532465A (en) * 1976-05-24 1978-01-11 Akzo Nv Novel tetracyclic derivative* its preparation and formulations containing same
JPH02111776A (ja) * 1988-08-26 1990-04-24 Akzo Nv 四環式抗うつ剤
WO2006106136A1 (en) * 2005-04-07 2006-10-12 N.V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5027477B2 (ja) * 2005-10-21 2012-09-19 住友化学株式会社 ジベンゾオキセピノピロール化合物およびその中間体の製造方法ならびに新規中間体
JP2011508751A (ja) * 2008-01-04 2011-03-17 ナームローゼ・フエンノートチヤツプ・オルガノン アセナピンの調製方法および前記方法において使用される中間生成物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4969697A (ja) * 1972-11-07 1974-07-05
JPS532465A (en) * 1976-05-24 1978-01-11 Akzo Nv Novel tetracyclic derivative* its preparation and formulations containing same
JPH02111776A (ja) * 1988-08-26 1990-04-24 Akzo Nv 四環式抗うつ剤
WO2006106136A1 (en) * 2005-04-07 2006-10-12 N.V. Organon Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1h-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP2166012A1 *
VADER J. ET AL.: "The syntheses of radiolabelled ORG 5222 and its main metabolite ORG 30526", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 34, no. 9, 1994, pages 845 - 869, XP008124259 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012013766A1 (en) 2010-07-29 2012-02-02 Laboratorios Lesvi, S.L. Novel process for the preparation of asenapine
JP2013533281A (ja) * 2010-07-29 2013-08-22 ラボラトリオス レスヴィ，エス．エル． アセナピンの新規な製造方法
US8653280B2 (en) 2010-07-29 2014-02-18 Laboratories Lesvi, S.L. Process for the preparation of asenapine
KR101810717B1 (ko) 2010-07-29 2017-12-19 라보라토리오스 레스비, 에스.엘. 아세나핀을 제조하는 신규한 방법
WO2013080069A1 (en) 2011-11-28 2013-06-06 Ranbaxy Laboratories Limited Process for the preparation of asenapine intermediate

Also Published As

Publication number Publication date
CA2688459A1 (en) 2009-01-15
JP2009035528A (ja) 2009-02-19
EP2166012A4 (en) 2011-08-17
AU2008273375A1 (en) 2009-01-15
JP5245428B2 (ja) 2013-07-24
US20110046393A1 (en) 2011-02-24
CN101679449A (zh) 2010-03-24
EP2166012A1 (en) 2010-03-24
AU2008273375B2 (en) 2012-07-26
CN101679449B (zh) 2012-05-30
US8288564B2 (en) 2012-10-16

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